Search Results - "IVANOVA, Pavlina T"

Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase by Kumari, Manju, Schoiswohl, Gabriele, Chitraju, Chandramohan, Paar, Margret, Cornaciu, Irina, Rangrez, Ashraf Y., Wongsiriroj, Nuttaporn, Nagy, Harald M., Ivanova, Pavlina T., Scott, Sarah A., Knittelfelder, Oskar, Rechberger, Gerald N., Birner-Gruenberger, Ruth, Eder, Sandra, Brown, H. Alex, Haemmerle, Guenter, Oberer, Monika, Lass, Achim, Kershaw, Erin E., Zimmermann, Robert, Zechner, Rudolf

“…Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis…”
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Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells[S] by Leamy, Alexandra K., Egnatchik, Robert A., Shiota, Masakazu, Ivanova, Pavlina T., Myers, David S., Brown, H. Alex, Young, Jamey D.

“…High levels of saturated FAs (SFAs) are acutely toxic to a variety of cell types, including hepatocytes, and have been associated with diseases such as type 2…”
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Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model by Gorden, D Lee, Ivanova, Pavlina T, Myers, David S, McIntyre, J Oliver, VanSaun, Michael N, Wright, J Kelly, Matrisian, Lynn M, Brown, H Alex

“…The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and progression to cirrhosis. While…”
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Quantitative analysis of glycerophospholipids by LC–MS: Acquisition, data handling, and interpretation by Myers, David S., Ivanova, Pavlina T., Milne, Stephen B., Brown, H. Alex

“…As technology expands what it is possible to accurately measure, so too the challenges faced by modern mass spectrometry applications expand. A high level of…”
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Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster by Faust, Joseph E, Manisundaram, Arvind, Ivanova, Pavlina T, Milne, Stephen B, Summerville, James B, Brown, H Alex, Wangler, Michael, Stern, Michael, McNew, James A

“…Peroxisomes are ubiquitous organelles that perform lipid and reactive oxygen species metabolism. Defects in peroxisome biogenesis cause peroxisome biogenesis…”
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Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116 by Yang, Mi Young, Hilton, Mary Beth, Seaman, Steven, Haines, Diana C., Nagashima, Kunio, Burks, Christina M., Tessarollo, Lino, Ivanova, Pavlina T., Brown, H. Alex, Umstead, Todd M., Floros, Joanna, Chroneos, Zissis C., St. Croix, Brad

“…GPR116 is an orphan seven-pass transmembrane receptor whose function has been unclear. Global disruption of the Gpr116 gene in mice revealed an unexpected,…”
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Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target by Beavers, William N, Rose, Kristie L, Galligan, James J, Mitchener, Michelle M, Rouzer, Carol A, Tallman, Keri A, Lamberson, Connor R, Wang, Xiaojing, Hill, Salisha, Ivanova, Pavlina T, Brown, H. Alex, Zhang, Bing, Porter, Ned A, Marnett, Lawrence J

“…Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile…”
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Identification of atypical ether-linked glycerophospholipid species in macrophages by mass spectrometry by Ivanova, Pavlina T., Milne, Stephen B., Brown, H. Alex

“…A large scale profiling and analysis of glycerophospholipid species in macrophages has facilitated the identification of several rare and atypical…”
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Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts[S] by Tribble, Emily K., Ivanova, Pavlina T., Grabon, Aby, Alb, James G., Faenza, Irene, Cocco, Lucio, Brown, H. Alex, Bankaitis, Vytas A.

“…A reliable method for purifying envelope-stripped nuclei from immortalized murine embryonic fibroblasts (iMEFs) was established. Quantitative profiling of the…”
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Lipid Profiling Reveals Arachidonate Deficiency in RAW264.7 Cells:  Structural and Functional Implications by Rouzer, Carol A., Ivanova, Pavlina T., Byrne, Mark O., Milne, Stephen B., Marnett, Lawrence J., Brown, H. Alex

“…Glycerophospholipids containing arachidonic acid (20:4) serve as the precursors for an array of biologically active lipid mediators, most of which are produced…”
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Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry by Ivanova, Pavlina T, Milne, Stephen B, Byrne, Mark O, Xiang, Yun, Brown, H Alex

“…Glycerophospholipids are the structural building blocks of the cellular membrane. In addition to creating a protective barrier around the cell, lipids are…”
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Dramatic Differences in the Roles in Lipid Metabolism of Two Isoforms of Diacylglycerol Kinase by Milne, Stephen B, Ivanova, Pavlina T, Armstrong, Michelle D, Myers, David S, Lubarda, Jovana, Shulga, Yulia V, Topham, Matthew K, Brown, H. Alex, Epand, Richard M

“…Lipid species changes for SV40-transformed fibroblasts from wild-type or from diacylglycerol kinase-ε (DGKε) or diacylglycerol kinase-α (DGKα) knockout mice…”
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targeted mass spectrometric analysis of phosphatidylinositol phosphate species by Milne, Stephen B, Ivanova, Pavlina T, DeCamp, Dianne, Hsueh, Robert C, Brown, H. Alex

“…The development of a new mass spectrometric lipid profiling methodology permits the identification of cellular phosphatidylinositol…”
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Computational lipidomics: a multiplexed analysis of dynamic changes in membrane lipid composition during signal transduction by Forrester, Jeffrey S, Milne, Stephen B, Ivanova, Pavlina T, Brown, H Alex

“…Recent successes in defining the roles of lipids in cell signaling have stimulated greater interest in these versatile biomolecules. Until recently, analysis…”
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Molecular Species of Phosphatidylinositol-Cycle Intermediates in the Endoplasmic Reticulum and Plasma Membrane by Shulga, Yulia V, Myers, David S, Ivanova, Pavlina T, Milne, Stephen B, Brown, H. Alex, Topham, Matthew K, Epand, Richard M

“…Phosphatidylinositol (PI) turnover is a process requiring both the plasma and ER membranes. We have determined the distribution of phosphatidic acid (PA) and…”
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Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1 by Klappe, Karin, Dijkhuis, Anne-Jan, Hummel, Ina, van Dam, Annie, Ivanova, Pavlina T, Milne, Stephen B, Myers, David S, Brown, H Alex, Permentier, Hjalmar, Kok, Jan W

“…We show that highly efficient depletion of sphingolipids in two different cell lines does not abrogate the ability to isolate Lubrol-based DRMs…”
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Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis by Li, John Zhong, Huang, Yongcheng, Karaman, Ruchan, Ivanova, Pavlina T, Brown, H Alex, Roddy, Thomas, Castro-Perez, Jose, Cohen, Jonathan C, Hobbs, Helen H

“…A genetic variant in PNPLA3 (PNPLA3(I148M)), a triacylglycerol (TAG) hydrolase, is a major risk factor for nonalcoholic fatty liver disease (NAFLD); however,…”
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The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance by Warrier, Manya, Shih, Diana M., Burrows, Amy C., Ferguson, Daniel, Gromovsky, Anthony D., Brown, Amanda L., Marshall, Stephanie, McDaniel, Allison, Schugar, Rebecca C., Wang, Zeneng, Sacks, Jessica, Rong, Xin, Vallim, Thomas de Aguiar, Chou, Jeff, Ivanova, Pavlina T., Myers, David S., Brown, H. Alex, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Liu, Xiuli, Parini, Paolo, Tontonoz, Peter, Lusis, Aldon J., Hazen, Stanley L., Temel, Ryan E., Brown, J. Mark

“…Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) have recently been linked to cardiovascular disease (CVD) risk. Here, we…”
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Lipidomics: a mass spectrometry based systems level analysis of cellular lipids by Ivanova, Pavlina T, Milne, Stephen B, Myers, David S, Brown, H Alex

“…Lipidomics is a logical outcome of the history and traditions of lipid biochemistry and advances in mass spectrometry are at the heart of a renaissance in…”
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Electrospray Ionization Mass Spectrometry Analysis of Changes in Phospholipids in RBL-2H3 Mastocytoma Cells during Degranulation by Ivanova, Pavlina T., Cerda, Blas A., Horn, David M., Cohen, Jared S., McLafferty, Fred W., Brown, H. Alex

“…Biological membranes contain an extraordinary diversity of lipids. Phospholipids function as major structural elements of cellular membranes, and analysis of…”
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