Search Results - "IURA, Yosuke"

Discovery and structure–activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2 by Fuchi, Nobuhiro, Iura, Yosuke, Kaneko, Hiroaki, Nitta, Aiko, Suyama, Kazuharu, Ueda, Hiroshi, Yamaguchi, Shinichi, Nishimura, Kazumi, Fujii, Shigeo, Sekiya, Yumiko, Yamada, Masateru, Takahashi, Toshiya

“…We report the discovery and structure–activity relationship of 2,6-disubstituted pyrazines, which are potent and selective CK2 inhibitors. Lead compound 1 was…”
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Enantio- and Diastereocontrolled Synthesis of an Angular Triquinane Sesquiterpene (+)-Arnicenone by Iura, Yosuke, Sugahara, Tsutomu, Ogasawara, Kunio

“…(+)-Arnicenone, a sesquiterpene of an angular triquinane isolated from Arnica plants, has been synthesized for the first time in an enantiocontrolled manner…”
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Oxidative resolution of 2-cyclopentenols by the asymmetric hydrogen transfer protocol by Iura, Yosuke, Sugahara, Tsutomu, Ogasawara, Kunio

“…A Ru II-chiral amine complex has accomplished oxidative resolution of the 2-cyclopentene-1-ols having a bicyclo[2.2.1]heptene background to afford the…”
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Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists by Nitta, Aiko, Iura, Yosuke, Inoue, Hideki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya

“…Optimization starting with our lead compound 1 (IC50=4.9nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward…”
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Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists by Nitta, Aiko, Iura, Yosuke, Tomioka, Hiroki, Sato, Ippei, Morihira, Koichiro, Kubota, Hirokazu, Morokata, Tatsuaki, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi, Imaoka, Takayuki, Takahashi, Toshiya

“…The synthesis and structure–activity relationships of ureas as CCR3 antagonists are described. Optimization starting with lead compound 2 (IC50=190nM) derived…”
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Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The 6-fluoro-2-naphthylmethyl derivatives were prepared, and their inhibitory activities against CCR3 and CYP2D6 were evaluated. In our previous study on…”
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Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Ohno, Kazuki, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…Acrylamide derivatives were prepared, and their inhibitory activity against CCR3 and in vitro metabolic stability against human liver microsomes (HLMs) were…”
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Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Hamada, Noritaka, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…The 6-fluoro-2-naphthylmethyl derivatives were prepared, and their inhibitory activities against CCR3 were evaluated. A novel class of potent CCR3 receptor…”
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Corrigendum to “Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists” [Bioorg. Med. Chem. 16 (2008) 144–156] by Sato, Ippei, Morihira, Koichiro, Inami, Hiroshi, Kubota, Hirokazu, Morokata, Tatsuaki, Suzuki, Keiko, Hamada, Noritaka, Iura, Yosuke, Nitta, Aiko, Imaoka, Takayuki, Takahashi, Toshiya, Takeuchi, Makoto, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

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Synthesis and structure-activity relationships of N-{1-[(6-fluoro2-naphthyl)methyl]piperidin-4-yl} benzamide derivatives as novel CCR3 antagonists : Nucleic Acid Modification for Fluoescence-Based Technologies by SATO, Ippei, MORIHIRA, Koichiro, TAKAHASHI, Toshiya, TAKEUCHI, Makoto, OHTA, Mitsuaki, TSUKAMOTO, Shin-Ichi, INAMI, Hiroshi, KUBOTA, Hirokazu, MOROKATA, Tatsuaki, SUZUKI, Keiko, HAMADA, Noritaka, IURA, Yosuke, NITTA, Aiko, IMAOKA, Takayuki

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