Search Results - "ITOH, Susumu"

TMEPAI family: involvement in regulation of multiple signalling pathways by Itoh, Susumu, Itoh, Fumiko

“…Abstract The TMEPAI family, composed of TMEPAI and C18ORF1, is known to inhibit transforming growth factor-β (TGF-β) signalling via its competition for binding…”
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Phototherapy for neonatal hyperbilirubinemia by Itoh, Susumu, Okada, Hitoshi, Kuboi, Toru, Kusaka, Takashi

“…Approximately 60 years ago in England, phototherapy for neonatal hyperbilirubinemia was used in clinical practice. It was introduced in Japan approximately…”
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Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species by Nii, Kohichiroh, Okada, Hitoshi, Itoh, Susumu, Kusaka, Takashi

“…Phototherapy using light-emitting diodes (LEDs) centered on the green spectrum, which has a high cyclobilirubin production rate, was as effective as that…”
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Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader by Nakano, Naoko, Fukuda, Kazuo, Tashiro, Etsu, Ishikawa, Haruka, Nagano, Waka, Kawamoto, Rie, Mori, Alice, Watanabe, Misao, Yamazaki, Ryu, Nakane, Takahisa, Naito, Mikihiko, Okamoto, Iwao, Itoh, Susumu

“…Abstract Dysregulated yes-associated protein (YAP) is involved in several malignant cancers. However, discovering a druggable YAP inhibitor(s) is difficult…”
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TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells by Vo Nguyen, Thanh Thao, Watanabe, Yukihide, Shiba, Aya, Noguchi, Masayuki, Itoh, Susumu, Kato, Mitsuyasu

“…TMEPAI/PMEPA1 is a transmembrane protein that was originally identified as a prostatic RNA, the synthesis of which is induced by testosterone or its…”
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Stereoselective aldol reactions of dihydroxyacetone derivatives catalyzed by chiral Zn2+ complexes by Yasuda, Masato, Saga, Yutaka, Tokunaga, Takuya, Itoh, Susumu, Aoki, Shin

“…The direct aldol reaction between a protected dihydroxyacetone derivative and 4-nitrobenzaldehyde catalyzed by chiral Zn2+ complexes of…”
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Environmental and soil characteristics in Ephedra habitats of Uzbekistan by Minami, Motoyasu, Taichi, Fujii, Honda, Yukako, Ueno, Kaoru, Shinozaki, Junichi, Itoh, Susumu, Takano, Akihito, Berdiyar, Jollibekov, Maltsev, Ivan Ivanovich, Nakane, Takahisa

“…In Uzbekistan, Ephedra distachya L., E. equisetina Bunge, E. foliata Boiss. ex C. A. Mey., E. lomatolepis Schrenk, and E. strobilacea Bunge show species…”
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Developmental changes in urinary coproporphyrin ratio in premature infants by Nakata, Yusei, Okada, Hitoshi, Itoh, Susumu, Kusaka, Takashi

“…Background Premature infants have a high concentration of conjugated bilirubin in their blood, although they have a poor glucuronide conjugation of bilirubin…”
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Serum caffeine concentrations in preterm infants: a retrospective study by Sugino, Masashiro, Kuboi, Toru, Noguchi, Yuta, Nishioka, Katsufumi, Tadatomo, Yoko, Kawaguchi, Nana, Sadamura, Takaaki, Nakano, Akiko, Konishi, Yukihiko, Koyano, Kosuke, Nakamura, Shinji, Okada, Hitoshi, Itoh, Susumu, Kusaka, Takashi

“…Therapeutic drug monitoring is generally unnecessary in caffeine treatment for apnea of prematurity, as serum caffeine concentrations in preterm infants are…”
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Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene by Nakano, Naoko, Kato, Mitsuyasu, Itoh, Susumu

“…We previously found that TCF7L2 could activate the TMEPAI gene efficiently, whereas LEF1 could not nearly augment its transcription. When we comprehended the…”
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Furosemide clearance in very preterm neonates early in life: A pilot study using scavenged samples by Okazaki, Kaoru, Fukuoka, Noriyasu, Kuboi, Toru, Unemoto, Jun, Kondo, Masatoshi, Kusaka, Takashi, Itoh, Susumu

“…Background Furosemide is an off‐label drug, frequently used as a diuretic in neonates with oliguria and/or edema. Its clearance in preterm neonates is lower…”
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Green light‐emitting diode phototherapy for neonatal hyperbilirubinemia: Randomized controlled trial by Kuboi, Toru, Kusaka, Takashi, Okada, Hitoshi, Arioka, Makoto, Nii, Kohichiroh, Takahashi, Megumi, Yamato, Satoshi, Sadamura, Takaaki, Jinnai, Wataru, Nakano, Akiko, Itoh, Susumu

“…Background The main photochemical pathway in phototherapy for neonatal hyperbilirubinemia is the production and elimination (in bile or urine) of…”
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Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules by Okuhira, Keiichiro, Shoda, Takuji, Omura, Risa, Ohoka, Nobumichi, Hattori, Takayuki, Shibata, Norihito, Demizu, Yosuke, Sugihara, Ryo, Ichino, Asato, Kawahara, Haruka, Itoh, Yukihiro, Ishikawa, Minoru, Hashimoto, Yuichi, Kurihara, Masaaki, Itoh, Susumu, Saito, Hiroyuki, Naito, Mikihiko

“…Development of novel small molecules that selectively degrade pathogenic proteins would provide an important advance in targeted therapy. Recently, we have…”
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Hour‐specific nomogram for transcutaneous Bilirubin in newborns in Myanmar by Yasuda, Saneyuki, Suzuki, Hiromi, Htun, Yinmon, Aye, Nant San San, Oo, Hnin, Oo, Aung Ko, Yu, Kay Zin, Sin, Khine Shwe, Itoh, Susumu, Kusaka, Takashi

“…Background Neonatal hyperbilirubinemia is a significant health problem in Myanmar, and the rate of kernicterus is also higher than in developed countries…”
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Endothelial-specific depletion of TGF-β signaling affects lymphatic function by Fukasawa, Kunpei, Hanada, Kako, Ichikawa, Kei, Hirashima, Masanori, Takagi, Takahiro, Itoh, Susumu, Watabe, Testuro, Itoh, Fumiko

“…BACKGROUNDTransforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis…”
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Transforming growth factor‐β signaling enhancement by long‐term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells by Furuta, Chiaki, Miyamoto, Tatsuki, Takagi, Takahiro, Noguchi, Yuri, Kaneko, Jyunya, Itoh, Susumu, Watanabe, Takuya, Itoh, Fumiko

“…Transforming growth factor‐β (TGF‐β) is a potent growth inhibitor in normal epithelial cells. However, a number of malignant tumors produce excessive amounts…”
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Fetal and neonatal bilirubin metabolism by Itoh, Susumu, Okada, Hitoshi, Koyano, Kosuke, Nakamura, Shinji, Konishi, Yukihiko, Iwase, Takashi, Kusaka, Takashi

“…Human fetal and neonatal bilirubin metabolism is centered on -bilirubin IXα (BR) due to the extremely low BR conjugating capacity of the liver. BR is a unique,…”
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Implication of TGF-β as a survival factor during tumour development by Itoh, Susumu, Itoh, Fumiko

“…Transforming growth factor (TGF)-β is a pleiotropic secretory protein which inhibits and potentiates tumour progression during early and late stage of…”
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Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells by Thakur, Noopur, Hamidi, Anahita, Song, Jie, Itoh, Susumu, Bergh, Anders, Heldin, Carl-Henrik, Landström, Maréne

“…Transforming growth factor β (TGF-β) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7 expression is induced by TGF-β…”
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Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions by Itoh, Fumiko, Itoh, Susumu, Adachi, Tomomi, Ichikawa, Kei, Matsumura, Yutaka, Takagi, Takahiro, Festing, Maria, Watanabe, Takuya, Weinstein, Michael, Karlsson, Stefan, Kato, Mitsuyasu

“…Transforming growth factor-β (TGF-β) is involved in vascular formation through activin receptor-like kinase (ALK)1 and ALK5. ALK5, which is expressed…”
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