Search Results - "ITOH, Kohji"

Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8 by Ohnishi, Yukiya, Tsuji, Daisuke, Itoh, Kohji

“…Autophagy is a highly conserved intracellular degrading system and its dysfunction is considered related to the cause of neurodegenerative disorders. A…”
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Glycan Recognition and Application of P-Type Lectins by Kiriyama, Kei, Itoh, Kohji

“…Cation-dependent mannose 6-phosphate receptor (CD-MPR) and cation-independent MPR (CI-MPR) belong to the P-type lectin family. Both intracellular and cell…”
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Novel synthetic biological study on intracellular distribution of human GlcNAc-1-phosphotransferase expressed in insect cells by Kiriyama, Kei, Fujioka, Keisuke, Kawai, Kaito, Mizuno, Teru, Shinohara, Yasuo, Itoh, Kohji

“…Abstract Many lysosomal enzymes contain N-glycans carrying mannose 6-phosphate (M6P) residues. Modifying lysosomal enzymes by M6P residues requires a two-step…”
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Sarcaglabrin A, a conjugate of C15 and C10 terpenes from the aerial parts of Sarcandra glabra by Yang, Xue-Rong, Tanaka, Naonobu, Tsuji, Daisuke, Lu, Feng-Lai, Yan, Xiao-Jie, Itoh, Kohji, Li, Dian-Peng, Kashiwada, Yoshiki

“…[Display omitted] •Investigation of a medicinal plant Sarcandra glabra gave sarcaglabrins A-C.•Their structures were assigned by spectroscopic analyses…”
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Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity by Yoshino, Yuki, Tanaka, Naonobu, Tsuji, Daisuke, Itoh, Kohji, Kashiwada, Yoshiki

“…Three new farnesylated coumarins, communiferulins A–C ( 1 – 3 ), and a farnesylated chromone, ferchromone ( 4 ), were isolated from the roots of an Apiaceous…”
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Limonoids from the aerial parts of Munronia pinnata by Yang, Xue-Rong, Tanaka, Naonobu, Tsuji, Daisuke, Lu, Feng-Lai, Yan, Xiao-Jie, Itoh, Kohji, Li, Dian-Peng, Kashiwada, Yoshiki

“…Six new limonoids, munropins A−F (1–6), were isolated from the aerial parts of a Chinese medicinal plant, Munronia pinnata (Meliaceae). The structures of 1–6…”
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Tyrosine Kinase Activity of Epidermal Growth Factor Receptor Is Regulated by GM3 Binding through Carbohydrate to Carbohydrate Interactions by Kawashima, Nagako, Yoon, Seon-Joo, Itoh, Kohji, Nakayama, Ken-ichi

“…Epidermal growth factor receptor (EGFR), an N-glycosylated transmembrane protein with an intracellular kinase domain, undergoes dimerization by ligand binding…”
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Formohyperins G–L, polycyclic prenylated benzoylphloroglucinols from the flowers of Hypericum formosanum by Takizawa, Rena, Shimomoto, Yusei, Tsuji, Daisuke, Imabayashi, Kiyoshi, Itoh, Kohji, Akagi, Reiko, Kashiwada, Yoshiki, Tanaka, Naonobu

“…Phytochemical study on the flowers of Hypericum formosanum Maxim. (Hypericaceae) led to the isolation of formohyperins G–L ( 1–6 ), whose structures were…”
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Reversible Dimerization of EGFR Revealed by Single-Molecule Fluorescence Imaging Using Quantum Dots by Kawashima, Nagako, Nakayama, Kenichi, Itoh, Kohji, Itoh, Tamitake, Ishikawa, Mitsuru, Biju, Vasudevanpillai

“…The current work explores intermolecular interactions involved in the lateral propagation of cell‐signaling by epidermal growth factor receptors (EGFRs)…”
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Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron by Niwa, Kanji, Tanaka, Naonobu, Shimomoto, Yusei, Tsuji, Daisuke, Kim, Sang-Yong, Kojoma, Mareshige, Itoh, Kohji, Chen, Chin-Ho, Lee, Kuo-Hsiung, Kashiwada, Yoshiki

“…Six dibenzo-1,4-dioxane derivatives ( 1 – 6 ) were isolated from the roots of a Hypericaceous plant Hypericum ascyron . Spectroscopic analyses revealed 2 and 4…”
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Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp by Lee, Sanghoon, Tanaka, Naonobu, Takahashi, Sakura, Tsuji, Daisuke, Kim, Sang-Yong, Kojoma, Mareshige, Itoh, Kohji, Kobayashi, Jun'ichi, Kashiwada, Yoshiki

“…Exploration for specialized metabolites of Okinawan marine sponges spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A ( ) and B (…”
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Generation of human induced pluripotent stem cells from oral mucosa by Miyoshi, Keiko, Tsuji, Daisuke, Kudoh, Keiko, Satomura, Kazuhito, Muto, Taro, Itoh, Kohji, Noma, Takafumi

“…Induced pluripotent stem (iPS) cells are one of the most promising sources for cell therapy in regenerative medicine. Using a patient's own genetically…”
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Highly phosphomannosylated enzyme replacement therapy for GM2 gangliosidosis by Tsuji, Daisuke, Akeboshi, Hiromi, Matsuoka, Kazuhiko, Yasuoka, Hiroko, Miyasaki, Eri, Kasahara, Yoshiko, Kawashima, Ikuo, Chiba, Yasunori, Jigami, Yoshifumi, Taki, Takao, Sakuraba, Hitoshi, Itoh, Kohji

“…Objective: Novel recombinant human lysosomal β‐hexosaminidase A (HexA) was developed for enzyme replacement therapy (ERT) for Tay‐Sachs and Sandhoff diseases,…”
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Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells by Nakano, Ayako, Tsuji, Daisuke, Miki, Hirokazu, Cui, Qu, El Sayed, Salah Mohamed, Ikegame, Akishige, Oda, Asuka, Amou, Hiroe, Nakamura, Shingen, Harada, Takeshi, Fujii, Shiro, Kagawa, Kumiko, Takeuchi, Kyoko, Sakai, Akira, Ozaki, Shuji, Okano, Kazuma, Nakamura, Takahiro, Itoh, Kohji, Matsumoto, Toshio, Abe, Masahiro

“…Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps…”
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A metabonomic approach identifies human urinary phenylacetylglutamine as a novel marker of interstitial cystitis by Fukui, Yousuke, Kato, Masao, Inoue, Yohji, Matsubara, Akio, Itoh, Kohji

“…An ultra-performance liquid chromatography–mass spectrometry (UPLC–MS) based metabonomic approach was applied to identify a candidate metabolite with not known…”
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A new heterozygous compound mutation in the CTSA gene in galactosialidosis by Nakajima, Hideki, Ueno, Miki, Adachi, Kaori, Nanba, Eiji, Narita, Aya, Tsukimoto, Jun, Itoh, Kohji, Kawakami, Atushi

“…Galactosialidosis is an autosomal recessive lysosomal storage disease caused by the combined deficiency of lysosomal β-galactosidase and neuraminidase due to a…”
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In Cellulo Crystallization of Human Neuraminidase 1 and Biological Roles of N‑Glycans by Tsukimoto, Jun, Takeuchi, Yoshie, Horii, Yuto, Iniwa, Toshiki, Fukushi, Yuri, Nishioka, So-ichiro, Itoh, Kohji

“…Human neuraminidase 1 (NEU1) is a lysosomal glycosidase that cleaves the terminal sialic acids of sialylglycoconjugates. NEU1 is biosynthesized in the…”
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1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes by Tsuji, Daisuke, Nakayama, Atsushi, Yamamoto, Riko, Nagano, Shuji, Taniguchi, Takashi, Sato, Ryota, Karanjit, Sangita, Muguruma, Naoki, Takayama, Tetsuji, Itoh, Kohji, Namba, Kosuke

“…1,3a,6a-Triazapentalene (TAP) is a compact fluorescent chromophore whose fluorescence properties vary greatly depending on the substituents on the TAP ring…”
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Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent by Nakayama, Atsushi, Otani, Akira, Inokuma, Tsubasa, Tsuji, Daisuke, Mukaiyama, Haruka, Nakayama, Akira, Itoh, Kohji, Otaka, Akira, Tanino, Keiji, Namba, Kosuke

“…For the fluorescence imaging of biologically active small compounds, the development of compact fluorophores that do not perturb bioactivity is required. Here…”
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Reversal of neuroinflammation in novel GS model mice by single i.c.v. administration of CHO-derived rhCTSA precursor protein by Horii, Yuto, Iniwa, Toshiki, Onitsuka, Masayoshi, Tsukimoto, Jun, Tanaka, Yuki, Ike, Hironobu, Fukushi, Yuri, Ando, Haruna, Takeuchi, Yoshie, Nishioka, So-ichiro, Tsuji, Daisuke, Ikuo, Mariko, Yamazaki, Naoshi, Takiguchi, Yoshiharu, Ishimaru, Naozumi, Itoh, Kohji

“…Galactosialidosis (GS) is a lysosomal cathepsin A (CTSA) deficiency. It associates with a simultaneous decrease of neuraminidase 1 (NEU1) activity and…”
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