Search Results - "ITO, Hikaru"

Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice by Yamawaki, Yosuke, Yoshioka, Norika, Nozaki, Kanako, Ito, Hikaru, Oda, Keisuke, Harada, Kana, Shirawachi, Satomi, Asano, Satoshi, Aizawa, Hidenori, Yamawaki, Shigeto, Kanematsu, Takashi, Akagi, Hiroyuki

“…•Lipopolysaccharide induced hippocampal microglia activation and depressive state.•Sodium butyrate reduced lipopolysaccharide-microglia activation and…”
Get full text

Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix by Ito, Hikaru, Nozaki, Kanako, Sakimura, Kenji, Abe, Manabu, Yamawaki, Shigeto, Aizawa, Hidenori

“…The lateral habenula (LHb) attracts a growing interest as a regulator of monoaminergic activity which were frequently reported to be defective in depression…”
Get full text

A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas by YOMOGITA, Hiroshi, ITO, Hikaru, HASHIMOTO, Kento, KUDO, Akihiko, FUKUSHIMA, Toshiaki, ENDO, Tsutomu, HIRATE, Yoshikazu, AKIMOTO, Yoshihiro, KOMADA, Masayuki, KANAI, Yoshiakira, MIYASAKA, Naoyuki, KANAI-AZUMA, Masami

“…In mice and humans, Nik-related protein kinase (Nrk) is an X-linked gene that encodes a serine/threonine kinase belonging to GCK group 4. Nrk knockout (Nrk KO)…”
Get full text

Effect of short-term temperature stress on fruit set and the expression of an auxin reporter gene and auxin synthesis genes in tomato by Ito, Hikaru, Kanayama, Yoshinori, Shibuya, Tomoki, Mohammed, Seedahmed A., Nishiyama, Manabu, Kato, Kazuhisa

“…•Effect of short-term temperature stress was evaluated during 5 days before anthesis.•Auxin-related factors were investigated using Micro-Tom as a model…”
Get full text

Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress by Nozaki, Kanako, Ito, Hikaru, Ohgidani, Masahiro, Yamawaki, Yosuke, Sahin, Ezgi Hatice, Kitajima, Takashi, Katsumata, Seishi, Yamawaki, Shigeto, Kato, Takahiro A., Aizawa, Hidenori

“…In preclinical models, it has been reported that social defeat stress activates microglial cells in the CNS. Translocator protein 18 kDa (TSPO) is a…”
Get full text

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation by Iwase, Shigeki, Brookes, Emily, Agarwal, Saurabh, Badeaux, Aimee I., Ito, Hikaru, Vallianatos, Christina N., Tomassy, Giulio Srubek, Kasza, Tomas, Lin, Grace, Thompson, Andrew, Gu, Lei, Kwan, Kenneth Y., Chen, Chinfei, Sartor, Maureen A., Egan, Brian, Xu, Jun, Shi, Yang

“…Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl…”
Get full text

Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1 by Fujita, Kyota, Mao, Ying, Uchida, Shigenori, Chen, Xigui, Shiwaku, Hiroki, Tamura, Takuya, Ito, Hikaru, Watase, Kei, Homma, Hidenori, Tagawa, Kazuhiko, Sudol, Marius, Okazawa, Hitoshi

“…YAP and its neuronal isoform YAPdeltaC are implicated in various cellular functions. We found that expression of YAPdeltaC during development, but not…”
Get full text

HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin‐1 knock‐in mice by Ito, Hikaru, Fujita, Kyota, Tagawa, Kazuhiko, Chen, Xigui, Homma, Hidenori, Sasabe, Toshikazu, Shimizu, Jun, Shimizu, Shigeomi, Tamura, Takuya, Muramatsu, Shin‐ichi, Okazawa, Hitoshi

“…Mutant ataxin‐1 (Atxn1), which causes spinocerebellar ataxia type 1 (SCA1), binds to and impairs the function of high‐mobility group box 1 (HMGB1), a crucial…”
Get full text

Dynamic changes of the phosphoproteome in postmortem mouse brains by Oka, Tsutomu, Tagawa, Kazuhiko, Ito, Hikaru, Okazawa, Hitoshi

“…Protein phosphorylation is deeply involved in the pathological mechanism of various neurodegenerative disorders. However, in human pathological samples,…”
Get full text

Mutant huntingtin impairs Ku70-mediated DNA repair by Enokido, Yasushi, Tamura, Takuya, Ito, Hikaru, Arumughan, Anup, Komuro, Akihiko, Shiwaku, Hiroki, Sone, Masaki, Foulle, Raphaele, Sawada, Hirohide, Ishiguro, Hiroshi, Ono, Tetsuya, Murata, Miho, Kanazawa, Ichiro, Tomilin, Nikolai, Tagawa, Kazuhiko, Wanker, Erich E, Okazawa, Hitoshi

“…DNA repair defends against naturally occurring or disease-associated DNA damage during the long lifespan of neurons and is implicated in polyglutamine disease…”
Get full text

Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice by Yamawaki, Yosuke, Shirawachi, Satomi, Mizokami, Akiko, Nozaki, Kanako, Ito, Hikaru, Asano, Satoshi, Oue, Kana, Aizawa, Hidenori, Yamawaki, Shigeto, Hirata, Masato, Kanematsu, Takashi

“…Peripheral lipopolysaccharide (LPS) injection induces systemic inflammation through the activation of the inhibitor of nuclear factor kappa B (NF-κB) kinase…”
Get full text

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases by Fujita, Kyota, Nakamura, Yoko, Oka, Tsutomu, Ito, Hikaru, Tamura, Takuya, Tagawa, Kazuhiko, Sasabe, Toshikazu, Katsuta, Asuka, Motoki, Kazumi, Shiwaku, Hiroki, Sone, Masaki, Yoshida, Chisato, Katsuno, Masahisa, Eishi, Yoshinobu, Murata, Miho, Paul Taylor, J., Wanker, Erich E., Kono, Kazuteru, Tashiro, Satoshi, Sobue, Gen, La Spada, Albert R., Okazawa, Hitoshi

“…It is hypothesized that a common underlying mechanism links multiple neurodegenerative disorders. Here we show that transitional endoplasmic reticulum ATPase…”
Get full text

Permeability and blood compatibility of nanoporous parylene film-coated polyethersulfone membrane under long-term blood diffusion by Setia Prihandana, Gunawan, Ito, Hikaru, Sanada, Ippei, Nishinaka, Yuya, Kanno, Yoshihiko, Miki, Norihisa

“…ABSTRACT Nanoporous polyethersulfone (PES) membranes are widely used in dialysis systems due to their permeability and diffusion characteristics. However, PES…”
Get full text

Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells by Li, Chan, Ito, Hikaru, Fujita, Kyota, Shiwaku, Hiroki, Qi, Yunlong, Tagawa, Kazuhiko, Tamura, Takuya, Okazawa, Hitoshi

“…PQBP1 is a nuclear-cytoplasmic shuttling protein that is engaged in RNA metabolism and transcription. In mouse embryonic brain, our previous in situ…”
Get full text

Solute diffusion through fibrotic tissue formed around protective cage system for implantable devices by Prihandana, Gunawan Setia, Ito, Hikaru, Tanimura, Kohei, Yagi, Hiroshi, Hori, Yuki, Soykan, Orhan, Sudo, Ryo, Miki, Norihisa

“…This article presents the concept of an implantable cage system that can house and protect implanted biomedical sensing and therapeutic devices in the body…”
Get full text

Antithrombogenicity of Fluorinated Diamond-Like Carbon Films Coated Nano Porous Polyethersulfone (PES) Membrane by Prihandana, Gunawan S, Sanada, Ippei, Ito, Hikaru, Noborisaka, Mayui, Kanno, Yoshihiko, Suzuki, Tetsuya, Miki, Norihisa

“…A nano porous polyethersulfone (PES) membrane is widely used for aspects of nanofiltration, such as purification, fractionation and dialysis. However, the…”
Get full text

Knock-down of PQBP1 impairs anxiety-related cognition in mouse by Ito, Hikaru, Yoshimura, Natsue, Kurosawa, Masaru, Ishii, Shunsuke, Nukina, Nobuyuki, Okazawa, Hitoshi

“…PQBP1 (polyglutamine tract-binding protein 1) is a causative gene for a relatively frequent X-linked syndromic and non-syndromic mental retardation (MR). To…”
Get full text

Evaluation of refractive correction for standard automated perimetry in eyes wearing multifocal contact lenses by Hirasawa, Kazunori, Ito, Hikaru, Ohori, Yukari, Takano, Yui, Shoji, Nobuyuki

“…To evaluate the refractive correction for standard automated perimetry (SAP) in eyes with refractive multifocal contact lenses (CL) in healthy young…”
Get full text

Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease by Inagaki, Reina, Tagawa, Kazuhiko, Qi, Mei-Ling, Enokido, Yasushi, Ito, Hikaru, Tamura, Takuya, Shimizu, Shigeomi, Oyanagi, Kityomitsu, Arai, Nobutaka, Kanazawa, Ichiro, Wanker, Erich E, Okazawa, Hitoshi

“…Selective vulnerability of neurons is a critical feature of neurodegenerative diseases, but the underlying molecular mechanisms remain largely unknown. We here…”
Get full text

Water-Permeable Dialysis Membranes for Multi-Layered Microdialysis System by To, Naoya, Sanada, Ippei, Ito, Hikaru, Prihandana, Gunawan S., Morita, Shinya, Kanno, Yoshihiko, Miki, Norihisa

Get full text