Search Results - "ITO, Emiko"

Transplantation of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Is Superior to Somatic Stem Cell Therapy for Restoring Cardiac Function and Oxygen Consumption in a Porcine Model of Myocardial Infarction by Ishida, Masaru, Miyagawa, Shigeru, Saito, Atsuhiro, Fukushima, Satsuki, Harada, Akima, Ito, Emiko, Ohashi, Fumiya, Watabe, Tadashi, Hatazawa, Jun, Matsuura, Katsuhisa, Sawa, Yoshiki

“…BACKGROUNDSomatic stem cell (SC) therapy can improve cardiac performance following ischemic injury. In this study, we investigated whether induced pluripotent…”
Get full text

Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application by Ito, Emiko, Miyagawa, Shigeru, Takeda, Maki, Kawamura, Ai, Harada, Akima, Iseoka, Hiroko, Yajima, Shin, Sougawa, Nagako, Mochizuki-Oda, Noriko, Yasuda, Satoshi, Sato, Yoji, Sawa, Yoshiki

“…Transplantation of cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSC-CMs) is a promising treatment for heart failure, but residual…”
Get full text

Development of a drug screening system using three-dimensional cardiac tissues containing multiple cell types by Takeda, Maki, Miyagawa, Shigeru, Ito, Emiko, Harada, Akima, Mochizuki-Oda, Noriko, Matsusaki, Michiya, Akashi, Mitsuru, Sawa, Yoshiki

“…We hypothesized that an appropriate ratio of cardiomyocytes, fibroblasts, endothelial cells, and extracellular matrix (ECM) factors would be required for the…”
Get full text

Elimination of residual undifferentiated induced pluripotent stem cells (iPSCs) using irradiation for safe clinical applications of iPSC-derived cardiomyocytes by Takeda, Maki, Ito, Emiko, Minami, Kazumasa, Harada, Akima, Mochizuki-Oda, Noriko, Sawa, Yoshiki, Miyagawa, Shigeru

“…A major concern in the clinical application of induced pluripotent stem cells (iPSCs) is the prevention of tumorigenesis after implantation. Stem cells with…”
Get full text

Establishment of a protocol to administer immunosuppressive drugs for iPS cell-derived cardiomyocyte patch transplantation in a rat myocardial infarction model by Ito, Emiko, Kawamura, Ai, Kawamura, Takuji, Takeda, Maki, Harada, Akima, Mochizuki-Oda, Noriko, Sawa, Yoshiki, Miyagawa, Shigeru

“…Transplantation of human allogeneic induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is a new, promising treatment for severe heart failure…”
Get full text

Phenotypic recapitulation and correction of desmoglein-2-deficient cardiomyopathy using human-induced pluripotent stem cell-derived cardiomyocytes by Shiba, Mikio, Higo, Shuichiro, Kondo, Takumi, Li, Junjun, Liu, Li, Ikeda, Yoshihiko, Kohama, Yasuaki, Kameda, Satoshi, Tabata, Tomoka, Inoue, Hiroyuki, Nakamura, Satoki, Takeda, Maki, Ito, Emiko, Takashima, Seiji, Miyagawa, Shigeru, Sawa, Yoshiki, Hikoso, Shungo, Sakata, Yasushi

“…Desmoglein-2, encoded by DSG2, is one of the desmosome proteins that maintain the structural integrity of tissues, including heart. Genetic mutations in DSG2…”
Get full text

Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells by Takeda, Maki, Miyagawa, Shigeru, Fukushima, Satsuki, Saito, Atsuhiro, Ito, Emiko, Harada, Akima, Matsuura, Ryohei, Iseoka, Hiroko, Sougawa, Nagako, Mochizuki-Oda, Noriko, Matsusaki, Michiya, Akashi, Mitsuru, Sawa, Yoshiki

“…An in vitro drug-induced cardiotoxicity assay is a critical step in drug discovery for clinical use. The use of human induced pluripotent stem cell-derived…”
Get more information

Pivotal Role of Non-cardiomyocytes in Electromechanical and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissue by Iseoka, Hiroko, Miyagawa, Shigeru, Fukushima, Satsuki, Saito, Atsuhiro, Masuda, Shigeo, Yajima, Shin, Ito, Emiko, Sougawa, Nagako, Takeda, Maki, Harada, Akima, Lee, Jong-Kook, Sawa, Yoshiki

“…Although engineered cardiac tissues (ECTs) derived from induced pluripotent stem cells (iPSCs) are promising for myocardial regenerative therapy, the…”
Get more information

Immunologic targeting of CD30 eliminates tumourigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy by Sougawa, Nagako, Miyagawa, Shigeru, Fukushima, Satsuki, Kawamura, Ai, Yokoyama, Junya, Ito, Emiko, Harada, Akima, Okimoto, Kaori, Mochizuki-Oda, Noriko, Saito, Atsuhiro, Sawa, Yoshiki

“…Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating…”
Get full text

CXCL4/PF4 is a predictive biomarker of cardiac differentiation potential of human induced pluripotent stem cells by Ohashi, Fumiya, Miyagawa, Shigeru, Yasuda, Satoshi, Miura, Takumi, Kuroda, Takuya, Itoh, Masayoshi, Kawaji, Hideya, Ito, Emiko, Yoshida, Shohei, Saito, Atsuhiro, Sameshima, Tadashi, Kawai, Jun, Sawa, Yoshiki, Sato, Yoji

“…Selection of human induced pluripotent stem cell (hiPSC) lines with high cardiac differentiation potential is important for regenerative therapy and drug…”
Get full text

Case report: Transplantation of human induced pluripotent stem cell-derived cardiomyocyte patches for ischemic cardiomyopathy by Miyagawa, Shigeru, Kainuma, Satoshi, Kawamura, Takuji, Suzuki, Kota, Ito, Yoshito, Iseoka, Hiroko, Ito, Emiko, Takeda, Maki, Sasai, Masao, Mochizuki-Oda, Noriko, Shimamoto, Tomomi, Nitta, Yukako, Dohi, Hiromi, Watabe, Tadashi, Sakata, Yasushi, Toda, Koichi, Sawa, Yoshiki

“…Despite major therapeutic advances, heart failure, as a non-communicable disease, remains a life-threatening disorder, with 26 million patients worldwide,…”
Get full text

Pre-clinical evaluation of the efficacy and safety of human induced pluripotent stem cell-derived cardiomyocyte patch by Miyagawa, Shigeru, Kawamura, Takuji, Ito, Emiko, Takeda, Maki, Iseoka, Hiroko, Yokoyama, Junya, Harada, Akima, Mochizuki-Oda, Noriko, Imanishi-Ochi, Yukiko, Li, Junjun, Sasai, Masao, Kitaoka, Fumiyo, Nomura, Masaki, Amano, Naoki, Takahashi, Tomoko, Dohi, Hiromi, Morii, Eiichi, Sawa, Yoshiki

“…Cell- or tissue-based regenerative therapy is an attractive approach to treat heart failure. A tissue patch that can safely and effectively repair damaged…”
Get full text

Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes by Inoue, Hiroyuki, Nakamura, Satoki, Higo, Shuichiro, Shiba, Mikio, Kohama, Yasuaki, Kondo, Takumi, Kameda, Satoshi, Tabata, Tomoka, Okuno, Shota, Ikeda, Yoshihiko, Li, Junjun, Liu, Li, Yamazaki, Satoru, Takeda, Maki, Ito, Emiko, Takashima, Seiji, Miyagawa, Shigeru, Sawa, Yoshiki, Hikoso, Shungo, Sakata, Yasushi

“…Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic cardiomyopathy (AC). Restoration of deficient molecules can serve as…”
Get full text

In Vivo Differentiation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Yu, Tao, Miyagawa, Shigeru, Miki, Kenji, Saito, Atsuhiro, Fukushima, Satsuki, Higuchi, Takahiro, Kawamura, Masashi, Kawamura, Takuji, Ito, Emiko, Kawaguchi, Naomasa, Sawa, Yoshiki, Matsuura, Nariaki

“…Background: Induced pluripotent stem cells (iPSCs) hold promise for a new era in treating heart failure. However, the functional microstructure of iPSC-derived…”
Get full text

Toxicological studies on palytoxin and ostreocin-D administered to mice by three different routes by Ito, Emiko, Yasumoto, Takeshi

“…Palytoxin (PLT) first isolated from zoanthids is extremely lethal to animals by intraperitoneal or intravenous administration but shows little toxicity by…”
Get full text

Irradiation strongly reduces tumorigenesis of human induced pluripotent stem cells by Inui, Shoki, Minami, Kazumasa, Ito, Emiko, Imaizumi, Hiromasa, Mori, Seiji, Koizumi, Masahiko, Fukushima, Satsuki, Miyagawa, Shigeru, Sawa, Yoshiki, Matsuura, Nariaki

“…Abstract Induced pluripotent stem (iPS) cells have demonstrated they can undergo self-renewal, attain pluripotency, and differentiate into various types of…”
Get full text

Teratocarcinomas Arising from Allogeneic Induced Pluripotent Stem Cell-Derived Cardiac Tissue Constructs Provoked Host Immune Rejection in Mice by Kawamura, Ai, Miyagawa, Shigeru, Fukushima, Satsuki, Kawamura, Takuji, Kashiyama, Noriyuki, Ito, Emiko, Watabe, Tadashi, Masuda, Shigeo, Toda, Koichi, Hatazawa, Jun, Morii, Eiichi, Sawa, Yoshiki

“…Transplantation of induced pluripotent stem cell-derived cardiac tissue constructs is a promising regenerative treatment for cardiac failure: however, its…”
Get full text

Clinical Outcomes of Autologous Stem Cell–Patch Implantation for Patients With Heart Failure With Nonischemic Dilated Cardiomyopathy by Domae, Keitaro, Miyagawa, Shigeru, Yoshikawa, Yasushi, Fukushima, Satsuki, Hata, Hiroki, Saito, Shunsuke, Kainuma, Satoshi, Kashiyama, Noriyuki, Iseoka, Hiroko, Ito, Emiko, Harada, Akima, Takeda, Maki, Sakata, Yasushi, Toda, Koichi, Pak, Kyongsun, Yamada, Tomomi, Sawa, Yoshiki

“…Background Clinical effectiveness of autologous skeletal cell‐patch implantation for nonischemic dilated cardiomyopathy has not been clearly elucidated in…”
Get full text

Safety confirmation of induced pluripotent stem cell-derived cardiomyocyte patch transplantation for ischemic cardiomyopathy: first three case reports by Kawamura, Takuji, Ito, Yoshito, Ito, Emiko, Takeda, Maki, Mikami, Tsubasa, Taguchi, Takura, Mochizuki-Oda, Noriko, Sasai, Masao, Shimamoto, Tomomi, Nitta, Yukako, Yoshioka, Daisuke, Kawamura, Masashi, Kawamura, Ai, Misumi, Yusuke, Sakata, Yasushi, Sawa, Yoshiki, Miyagawa, Shigeru

“…IntroductionWith the expected increase in patients with heart failure and ischemic 15 cardiomyopathy, the development of myocardial regenerative medicine using…”
Get full text

Structural Changes in N‐Glycans on Induced Pluripotent Stem Cells Differentiating Toward Cardiomyocytes by Kawamura, Takuji, Miyagawa, Shigeru, Fukushima, Satsuki, Kashiyama, Noriyuki, Kawamura, Ai, Ito, Emiko, Saito, Atsuhiro, Maeda, Akira, Eguchi, Hiroshi, Toda, Koichi, Miyagawa, Shuji, Okuyama, Hiroomi, Sawa, Yoshiki

“…N‐Glycans were isolated from human induced pluripotent stem cells (iPSCs), iPSC‐derived cardiomyocytes (iPSC‐CMs), and human cardiomyocytes (hCMCs), and…”
Get full text