Search Results - "ITALIANO, Joseph E"

The incredible journey: From megakaryocyte development to platelet formation by Machlus, Kellie R, Italiano, Jr, Joseph E

“…Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called…”
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Platelets and the immune continuum by Semple, John W, Italiano, Joseph E, Freedman, John

“…Key Points Platelets have a plethora of soluble and cell-associated immunomodulatory molecules that can enhance and in some instances inhibit immune responses…”
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Evidence for a cytoplasmic proplatelet promoting factor that triggers platelet production by Italiano, Jr, Joseph E, Machlus, Kellie R

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Dynamic Visualization of Thrombopoiesis Within Bone Marrow by Junt, Tobias, Schulze, Harald, Chen, Zhao, Massberg, Steffen, Goerge, Tobias, Krueger, Andreas, Wagner, Denisa D, Graf, Thomas, Italiano, Joseph E. Jr, Shivdasani, Ramesh A, von Andrian, Ulrich H

“…Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here we describe the use of…”
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Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation by Machlus, Kellie R., Thon, Jonathan N., Italiano, Joseph E.

“…Summary Platelets are essential for haemostasis, and thrombocytopenia (platelet counts <150 × 109/l) is a major clinical problem encountered across a number of…”
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Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis by Battinelli, Elisabeth M., Markens, Beth A., Italiano, Joseph E.

“…An association between platelets, angiogenesis, and cancer has long been recognized, but the mechanisms linking them remains unclear. Platelets regulate new…”
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Don't you forget about me(gakaryocytes) by Tilburg, Julia, Becker, Isabelle C., Italiano, Joseph E.

“…Platelets (small, anucleate cell fragments) derive from large precursor cells, megakaryocytes (MKs), that reside in the bone marrow. MKs emerge from…”
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Cytoskeletal mechanics of proplatelet maturation and platelet release by Thon, Jonathan N, Montalvo, Alejandro, Patel-Hett, Sunita, Devine, Matthew T, Richardson, Jennifer L, Ehrlicher, Allen, Larson, Mark K, Hoffmeister, Karin, Hartwig, John H, Italiano, Joseph E. Jr

“…Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production…”
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Platelet bioreactor-on-a-chip by Thon, Jonathan N., Mazutis, Linas, Wu, Stephen, Sylman, Joanna L., Ehrlicher, Allen, Machlus, Kellie R., Feng, Qiang, Lu, Shijiang, Lanza, Robert, Neeves, Keith B., Weitz, David A., Italiano, Joseph E.

“…Platelet transfusions total >2.17 million apheresis-equivalent units per year in the United States and are derived entirely from human donors, despite…”
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CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathways by Johansson, Karl, Maouia, Amal, Rebetz, Johan, Marcoux, Geneviève, Shannon, Oonagh, Italiano, Joseph E., Narayanan, Padma, Henry, Scott, Shen, Lijiang, Semple, John W.

“…CpG oligonucleotides (ODNs) are synthetic single-stranded DNA sequences that act as immunostimulants. They have been increasingly used to treat several…”
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Clinical relevance of microparticles from platelets and megakaryocytes by Italiano, Joseph E, Mairuhu, Albert TA, Flaumenhaft, Robert

“…PURPOSE OF REVIEWPlatelet microparticles were identified more than 40 years ago and are the most abundant circulating microparticle subtype. Yet fundamental…”
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Does size matter in platelet production? by Thon, Jonathan N., Italiano, Joseph E.

“…Platelet (PLT) production represents the final stage of megakaryocyte (MK) development. During differentiation, bone marrow MKs extend and release long,…”
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Anticoagulation inhibits tumor cell–mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response by Battinelli, Elisabeth M., Markens, Beth A., Kulenthirarajan, Rajesh A., Machlus, Kellie R., Flaumenhaft, Robert, Italiano, Joseph E.

“…Platelets are a reservoir for angiogenic proteins that are secreted in a differentially regulated process. Because of the propensity for clotting, patients…”
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A Secreted Tyrosine Kinase Acts in the Extracellular Environment by Bordoli, Mattia R., Yum, Jina, Breitkopf, Susanne B., Thon, Jonathan N., Italiano, Joseph E., Xiao, Junyu, Worby, Carolyn, Wong, Swee-Kee, Lin, Grace, Edenius, Maja, Keller, Tracy L., Asara, John M., Dixon, Jack E., Yeo, Chang-Yeol, Whitman, Malcolm

“…Although tyrosine phosphorylation of extracellular proteins has been reported to occur extensively in vivo, no secreted protein tyrosine kinase has been…”
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CCL5 derived from platelets increases megakaryocyte proplatelet formation by Machlus, Kellie R., Johnson, Kelly E., Kulenthirarajan, Rajesh, Forward, Jodi A., Tippy, Mason D., Soussou, Thomas S., El-Husayni, Saleh H., Wu, Stephen K., Wang, Suming, Watnick, Randolph S., Italiano, Joseph E., Battinelli, Elisabeth M.

“…In times of physiological stress, platelet count can transiently rise. What initiates this reactive thrombocytosis is poorly understood. Intriguingly, we found…”
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Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis by Machlus, Kellie R., Wu, Stephen K., Vijey, Prakrith, Soussou, Thomas S., Liu, Zhi-Jian, Shacham, Eran, Unger, T.J., Kashyap, Trinayan, Klebanov, Boris, Sola-Visner, Martha, Crochiere, Marsha, Italiano, Joseph E., Landesman, Yosef

“…Selinexor is the first oral selective inhibitor of nuclear export compound tested for cancer treatment. Selinexor has demonstrated a safety therapy profile…”
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Microtubule and cortical forces determine platelet size during vascular platelet production by Thon, Jonathan N, Macleod, Hannah, Begonja, Antonija Jurak, Zhu, Jie, Lee, Kun-Chun, Mogilner, Alex, Hartwig, John H., Italiano, Joseph E.

“…Megakaryocytes release large preplatelet intermediates into the sinusoidal blood vessels. Preplatelets convert into barbell-shaped proplatelets in vitro to…”
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Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles by Flaumenhaft, Robert, Dilks, James R., Richardson, Jennifer, Alden, Eva, Patel-Hett, Sunita R., Battinelli, Elisabeth, Klement, Giannoula L., Sola-Visner, Martha, Italiano, Joseph E.

“…Platelet microparticles are a normal constituent of circulating blood. Several studies have demonstrated positive correlations between thrombotic states and…”
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Dynamic actin/septin network in megakaryocytes coordinates proplatelet elaboration by Becker, Isabelle C, Wilkie, Adrian R, Unger, Bret A, Sciaudone, Anthony R, Fatima, Farheen, Tsai, I-Ting, Xu, Ke, Machlus, Kellie R, Italiano, Joseph E

“…Megakaryocytes (MK) undergo extensive cytoskeletal rearrangements as they give rise to platelets. While cortical microtubule sliding has been implicated in…”
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IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs by Nishimura, Satoshi, Nagasaki, Mika, Kunishima, Shinji, Sawaguchi, Akira, Sakata, Asuka, Sakaguchi, Hiroyasu, Ohmori, Tsukasa, Manabe, Ichiro, Italiano, Jr, Joseph E, Ryu, Tomiko, Takayama, Naoya, Komuro, Issei, Kadowaki, Takashi, Eto, Koji, Nagai, Ryozo

“…Intravital visualization of thrombopoiesis revealed that formation of proplatelets, which are cytoplasmic protrusions in bone marrow megakaryocytes (MKs), is…”
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