BIOSYNTHESIS OF β-(ISOXAZOLIN-5-ON-2-YL)ALANINE, THE PRECURSOR OF THE NEUROTOXIC AMINO ACID β-n-OXALYL-L-α, β-DIAMINOPROPIONIC ACID

β-(Isoxazolin-5-on-2-yl)alanine (BlA), a biosynthetic precursor of the neurotoxic amino acid β-N-oxalyl-L-α, β-diaminopropionic acid (ODAP), was confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthase in higher plants. Some properties of this enzyme in the bios...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 39; no. 12; pp. 3376 - 3377
Main Authors:	IKEGAMI, Fumio, ITAKAGI, Satoshi, ISHIKAWA, Tsutomu, ONGENA, Godelieve, KUO, Yu-Haey, LAMBEIN, Femand, MURAKOSHI, Isamu
Format:	Journal Article
Language:	English
Published:	Japan The Pharmaceutical Society of Japan 1991
Subjects:	Alanine - analogs & derivatives Amino Acids, Diamino biosynthesis cysteine synthase Fabaceae - metabolism Isoxazoles Lathyrus sativus Leguminosae neurotoxin Neurotoxins - biosynthesis O-acetyl-L-serine Pisum sativum Plants, Medicinal β-(isoxazolin-5-on-2-yl)alanine β-N-oxalyl-L-α, β-diaminopropionic acid
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Summary:	β-(Isoxazolin-5-on-2-yl)alanine (BlA), a biosynthetic precursor of the neurotoxic amino acid β-N-oxalyl-L-α, β-diaminopropionic acid (ODAP), was confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthase in higher plants. Some properties of this enzyme in the biosynthesis of BlA are described.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.39.3376