Search Results - "ISRAËL, Maurice"

l-arginine improves dystrophic phenotype in mdx mice by Voisin, Vincent, Sébrié, Catherine, Matecki, Stéfan, Yu, Hua, Gillet, Brigitte, Ramonatxo, Michèle, Israël, Maurice, De la Porte, Sabine

“…A possible treatment for Duchenne muscular dystrophies would be to compensate for dystrophin loss by increasing the expression of utrophin, another…”
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Inhibition of the ketolytic acetyl CoA supply to tumors could be their “Achilles heel” by Israël, Maurice, Schwartz, Laurent

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The metabolic advantage of tumor cells by Israël, Maurice, Schwartz, Laurent

“…1- Oncogenes express proteins of "Tyrosine kinase receptor pathways", a receptor family including insulin or IGF-Growth Hormone receptors. Other oncogenes…”
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An alteration of the endocrine pancreas involved in cancer by Israël, Maurice

“…Tumor cells display hybrid metabolic features: some of their enzymes are phosphorylated as normally observed when catabolic hormones stimulate Gs-coupled…”
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Cancer Metabolism: Fasting Reset, the Keto-Paradox and Drugs for Undoing by Israël, Maurice, Berg, Eric, Tenenbaum, Guy

“…In tumor cells, ketolysis "via" succinyl-CoA: 3-oxoacid-CoAtransferase (SCOT) and acetyl-CoA acetyltransferase 1 (ACAT1) is a major source of mitochondrial…”
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Increase in External Glutamate and NMDA Receptor Activation Contribute to H2O2‐Induced Neuronal Apoptosis by Mailly, Franck, Marin, Philippe, Israël, Maurice, Glowinski, Jacques, Prémont, Joël

“…: The present study aims to investigate the role of extracellular glutamate and NMDA receptor stimulation in the neuronal death induced by a transient exposure…”
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A possible primary cause of cancer: deficient cellular interactions in endocrine pancreas by Israël, Maurice

“…Cancer is a devastating type of disease. New and innovative ways to tackle cancers that have so far proved refractive to conventional therapies is urgently…”
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Nitric oxide and l-arginine cause an accumulation of utrophin at the sarcolemma: a possible compensation for dystrophin loss in Duchenne muscular dystrophy by Chaubourt, E, Fossier, P, Baux, G, Leprince, C, Israël, M, De La Porte, S

“…Duchenne muscular dystrophy (DMD), a severe X-linked recessive disorder which results in progressive muscle degeneration, is due to a lack of dystrophin, a…”
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Low doses of arginine butyrate derivatives improve dystrophic phenotype and restore membrane integrity in DMD models by Vianello, Sara, Consolaro, Francesca, Bich, Claudia, Cancela, José‐Manuel, Roulot, Morgane, Lanchec, Erwan, Touboul, David, Brunelle, Alain, Israël, Maurice, Benoit, Evelyne, Porte, Sabine

“…ABSTRACT A new approach to treating Duchenne muscular dystrophy was investigated by using the ester or amide covalent association of arginine [nitric oxide…”
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Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin by Schwartz, Laurent, Guais, Adeline, Israël, Maurice, Junod, Bernard, Steyaert, Jean-Marc, Crespi, Elisabetta, Baronzio, Gianfranco, Abolhassani, Mohammad

“…Summary Cellular metabolic alterations are now well described as implicated in cancer and some strategies are currently developed to target these different…”
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Arginine butyrate: a therapeutic candidate for Duchenne muscular dystrophy by Vianello, Sara, Yu, Hua, Voisin, Vincent, Haddad, Hafedh, He, Xun, Foutz, Arthur S., Sebrié, Catherine, Gillet, Brigitte, Roulot, Morgane, Fougerousse, Françoise, Perronnet, Caroline, Vaillend, Cyrille, Matecki, Stefan, Escolar, Diana, Bossi, Laura, Israël, Maurice, Porte, Sabine

“…As a strategy to treat Duchenne muscular dystrophy, we used arginine butyrate, which combines two pharmacological activities: nitric oxide pathway activation,…”
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A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results by SCHWARTZ, Laurent, ABOLHASSANI, Mohammad, GUAIS, Adeline, SANDERS, Edward, STEYAERT, Jean-Marc, CAMPION, Frederic, ISRAËL, Maurice

“…The impact of metabolic dysregulation on tumor development has long been established. We have targeted two enzymes that are altered during carcinogenesis:…”
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Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice by Abolhassani, Mohammad, Guais, Adeline, Sanders, Edward, Campion, Frédéric, Fichtner, Iduna, Bonte, Jacques, Baronzio, Gianfranco, Fiorentini, Giammaria, Israël, Maurice, Schwartz, Laurent

“…Summary Alterations in metabolic pathways are known to characterize cancer. In order to suppress cancer growth, however, multiple proteins involved in these…”
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Hyperosmotic stress contributes to mouse colonic inflammation through the methylation of protein phosphatase 2A by Schwartz, Laurent, Abolhassani, Mohammad, Pooya, Mohammad, Steyaert, Jean-Marc, Wertz, Xavier, Israël, Maurice, Guais, Adeline, Chaumet-Riffaud, Philippe

“…There are several reports suggesting hyperosmotic contents in the feces of patients suffering from inflammatory bowel disease (IBD). Previous works have…”
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Acetylcholine release and the cholinergic genomic locus by Israël, M, Dunant, Y

“…Choline acetyltransferase and vesicular acetylcholine-transporter genes are adjacent and coregulated. They define a cholinergic locus that can be turned on…”
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Acetylcholine synthesis and quantal release reconstituted by transfection of mediatophore and choline acetyltranferase cDNAs by Bloc, Alain, Bugnard, Elisabeth, Dunant, Yves, Falk-Vairant, Jean, Israël, Maurice, Loctin, Françoise, Roulet, Emmanuelle

“…Neuroblastoma N18TG‐2 cells cannot synthesize or release acetylcholine (ACh), and do not express proteins involved in transmitter storage and vesicle fusion…”
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Effect of brefeldin A on acetylcholine release from glioma C6BU-1 cells by Malo, Michel, Vurpillot, Cédric, Tomasi, Monique, Bruner, Jan, Stinnakre, Jacques, Israël, Maurice

“…The glial C6BU-1 cell line, loaded with acetylcholine can release this neurotransmitter. This study was aimed at determining whether disruption of the…”
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Continuous determination by a chemiluminescent method of acetylcholine release and compartmentation in Torpedo electric organ synaptosomes by Israël, M, Lesbats, B

“…The detection of acetylcholine (ACh) with a chemiluminescent procedure enables one to follow continuously the release of transmitter from stimulated…”
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Pyruvate and lactate protect striatal neurons against N-methyl-d-aspartate-induced neurotoxicity by Maus, Marion, Marin, Philippe, Israël, Maurice, Glowinski, Jacques, Prémont, Joël

“…A sustained release of glutamate contributes to neuronal loss during cerebral ischaemia. Using cultured mouse striatal neurons, we observed that glucose…”
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Application to mammalian tissues of the chemiluminescent method for detecting acetylcholine by Israël, M, Lesbats, B

“…It is now possible to extend to mammalian tissues the chemiluminescent acetylcholine assay. Mammalian tissue extracts must be treated with oxidants (which is…”
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