Search Results - "ISOLA, Jorma"

Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation by Barok, Mark, Puhka, Maija, Vereb, Gyorgy, Szollosi, Janos, Isola, Jorma, Joensuu, Heikki

“…Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present…”
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Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy by Bychkov, Dmitrii, Linder, Nina, Tiulpin, Aleksei, Kücükel, Hakan, Lundin, Mikael, Nordling, Stig, Sihto, Harri, Isola, Jorma, Lehtimäki, Tiina, Kellokumpu-Lehtinen, Pirkko-Liisa, von Smitten, Karl, Joensuu, Heikki, Lundin, Johan

“…The treatment of patients with ERBB2 (HER2)-positive breast cancer with anti- ERBB2 therapy is based on the detection of ERBB2 gene amplification or protein…”
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UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma by Puttonen, Maya, Isola, Jorma, Ylinen, Onni, Böhling, Tom, Koljonen, Virve, Sihto, Harri

“…Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light…”
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ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 by Tuominen, Vilppu J, Ruotoistenmäki, Sanna, Viitanen, Arttu, Jumppanen, Mervi, Isola, Jorma

“…Accurate assessment of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 is essential in the histopathologic diagnostics of breast cancer…”
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Triple-negative and HER2-positive breast cancers found by mammography screening show excellent prognosis by Alanko, Johanna, Tanner, Minna, Vanninen, Ritva, Auvinen, Anssi, Isola, Jorma

“…Purpose Our purpose was to explore the prognosis of aggressive breast cancers of the HER2 oncogene amplification (HER2 +) and triple-negative (TN) subtypes…”
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Trastuzumab-DM1 is highly effective in preclinical models of HER2-positive gastric cancer by Barok, Mark, Tanner, Minna, Köninki, Katri, Isola, Jorma

“…Abstract Background A novel antibody–drug conjugate (trastuzumab-DM1, T-DM1) is currently in clinical trials for patients with trastuzumab resistant…”
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A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies by Popp, Alina, Taavela, Juha, Graziano, Paolo, Parente, Paola, Covelli, Claudia, Lamacchia, Carmela, Andriulli, Angelo, Mäki, Markku, Isola, Jorma

“…Background The histopathologic diagnosis of celiac disease (CD) may be challenging when the duodenal biopsies mucosal injury is limited. Intraepithelial…”
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HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data by Leo, Angelo Di, Dr, Desmedt, Christine, PhD, Bartlett, John M S, Prof, Piette, Fanny, PhD, Ejlertsen, Bent, MD, Pritchard, Kathleen I, Prof, Larsimont, Denis, MD, Poole, Christopher, Prof, Isola, Jorma, Prof, Earl, Helena, Prof, Mouridsen, Henning, MD, O'Malley, Frances P, MD, Cardoso, Fatima, MD, Tanner, Minna, MD, Munro, Alison, PhD, Twelves, Chris J, Prof, Sotiriou, Christos, MD, Shepherd, Lois, MD, Cameron, David, Prof, Piccart, Martine J, Prof, Buyse, Marc, PhD

“…Summary Background Prediction of response to anthracycline-based therapy for breast cancer is challenging. We aimed to assess the value of HER2 and TOP2A as…”
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Fluorouracil, Epirubicin, and Cyclophosphamide With Either Docetaxel or Vinorelbine, With or Without Trastuzumab, As Adjuvant Treatments of Breast Cancer: Final Results of the FinHer Trial by JOENSUU, Heikki, BONO, Petri, HELLE, Leena, INGALSUO, Seija, PAJUNEN, Marjo, HUUSKO, Mauri, SALMINEN, Tapio, AUVINEN, Päivi, LEINONEN, Hannu, LEINONEN, Mika, ISOLA, Jorma, KELLOKUMPU-LEHTINEN, Pirkko-Liisa, KATAJA, Vesa, ALANKO, Tuomo, KOKKO, Riitta, ASOLA, Raija, UTRIAINEN, Tapio, TURPEENNIEMI-HUJANEN, Taina, JYRKKIÖ, Sirkku, MÖYKKYNEN, Kari

“…Docetaxel has not been compared with vinorelbine as adjuvant treatment of early breast cancer. Efficacy and long-term safety of a short course of adjuvant…”
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Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer by Luhtala, Satu, Staff, Synnöve, Kallioniemi, Anne, Tanner, Minna, Isola, Jorma

“…Human epidermal growth factor receptor HER3 (ErbB3), especially in association with its relative HER2 (ErbB2), is known as a key oncogene in breast tumour…”
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CIP2A Is Associated with Human Breast Cancer Aggressivity by COME, Christophe, LAINE, Anni, KALLIONIEMI, Olli, THEZENAS, Simon, WESTERMARCK, Jukka, CHANRION, Maïa, EDGREN, Henrik, MATTILA, Elina, XIAOLING LIU, JONKERS, Jos, IVASKA, Johanna, ISOLA, Jorma, DARBON, Jean-Marie

“…Purpose: To investigate the clinical relevance of the recently characterized human oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A) in human…”
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Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study by Sihto, Harri, Lundin, Johan, Lundin, Mikael, Lehtimäki, Tiina, Ristimäki, Ari, Holli, Kaija, Sailas, Liisa, Kataja, Vesa, Turpeenniemi-Hujanen, Taina, Isola, Jorma, Heikkilä, Päivi, Joensuu, Heikki

“…Some molecular subtypes of breast cancer have preferential sites of distant relapse. The protein expression pattern of the primary tumor may influence the…”
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The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment by Isola, Jorma, Mäki, Markku, Hils, Martin, Pasternack, Ralf, Viiri, Keijo, Dotsenko, Valeriia, Montonen, Toni, Zimmermann, Timo, Mohrbacher, Ralf, Greinwald, Roland, Schuppan, Detlef

“…The enzyme transglutaminase 2 (TG2) plays a key role in celiac disease (CeD) pathogenesis. Active TG2 is located mainly extracellularly in the lamina propria…”
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Correction to: A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies by Popp, Alina, Taavela, Juha, Graziano, Paolo, Parente, Paola, Covelli, Claudia, Lamacchia, Carmela, Andriulli, Angelo, Mäki, Markku, Isola, Jorma

“…The original version of the article unfortunately contained an error in the first name and the surname of the all authors in the author group. Below is the…”
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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity by Saal, Lao H, Johansson, Peter, Holm, Karolina, Gruvberger-Saal, Sofia K, She, Qing-Bai, Maurer, Matthew, Koujak, Susan, Ferrando, Adolfo A, Malmström, Per, Memeo, Lorenzo, Isola, Jorma, Bendahl, Pär-Ola, Rosen, Neal, Hibshoosh, Hanina, Ringnér, Markus, Borg, Åke, Parsons, Ramon

“…Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid…”
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Apolipoprotein A4 Defines the Villus-Crypt Border in Duodenal Specimens for Celiac Disease Morphometry by Taavela, Juha, Viiri, Keijo, Välimäki, Anna, Sarin, Jani, Salonoja, Kristiina, Mäki, Markku, Isola, Jorma

“…Histological evaluation of the small intestinal mucosa is the cornerstone of celiac disease diagnostics and an important outcome in scientific studies…”
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Preservation of nucleic acids and tissue morphology in paraffin-embedded clinical samples: comparison of five molecular fixatives by Staff, Synnöve, Kujala, Paula, Karhu, Ritva, Rökman, Annika, Ilvesaro, Joanna, Kares, Saara, Isola, Jorma

“…Formalin fixation preserves tissue morphology at the expense of macromolecule integrity. Freshly frozen samples are the golden standard for DNA and RNA…”
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Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line by NAGY, Peter, FRIEDLÄNDER, Elza, TANNER, Minna, KAPANEN, Anita I, CARRAWAY, Kermit L, ISOLA, Jorma, JOVIN, Thomas M

“…Overexpression of erbB2 in breast tumors is associated with poor prognosis and is a target of receptor-oriented cancer therapy. Trastuzumab (Herceptin), a…”
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Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies by Taavela, Juha, Viiri, Keijo, Popp, Alina, Oittinen, Mikko, Dotsenko, Valeriia, Peräaho, Markku, Staff, Synnöve, Sarin, Jani, Leon, Francisco, Mäki, Markku, Isola, Jorma

“…There is an unmet need for novel treatments, such as drugs or vaccines, adjunctive to or replacing a burdensome life-long gluten-free diet for coeliac disease…”
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Iron Transporter Protein Expressions in Children with Celiac Disease by Repo, Marleena, Hannula, Markus, Taavela, Juha, Hyttinen, Jari, Isola, Jorma, Hiltunen, Pauliina, Popp, Alina, Kaukinen, Katri, Kurppa, Kalle, Lindfors, Katri

“…Anemia is a frequent finding in children with celiac disease but the detailed pathophysiological mechanisms in the intestine remain obscure. One possible…”
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