Search Results - "ISHWARLAL JIALAL"

Toll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective by Jialal, Ishwarlal, Kaur, Harmeet, Devaraj, Sridevi

“…Context: The prevalence of both obesity and metabolic syndrome (MetS) is increasing at alarming rates globally. Both predispose to diabetes, cardiovascular…”
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Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes by Reddy, Priya, Lent-Schochet, Daniella, Ramakrishnan, Neeraj, McLaughlin, Matthew, Jialal, Ishwarlal

“…Metabolic syndrome (MetS) describes a cluster of cardio-metabolic factors that predispose to type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular…”
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C-Reactive Protein Polarizes Human Macrophages to an M1 Phenotype and Inhibits Transformation to the M2 Phenotype by Devaraj, Sridevi, Jialal, Ishwarlal

“…OBJECTIVE—Inflammation is pivotal in atherosclerosis. Monocyte-macrophages are crucial in atherosclerosis. Monocytes can develop into subsetsclassically (M1)…”
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Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors by Dasu, Mohan R, Jialal, Ishwarlal

“…Type 2 diabetes (T2DM) is characterized by hyperglycemia, dyslipidemia, and increased inflammation. Previously, we showed that high glucose (HG) induces…”
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Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects by Dasu, Mohan R, Devaraj, Sridevi, Park, Samuel, Jialal, Ishwarlal

“…OBJECTIVE: Individuals with type 2 diabetes have a myriad of metabolic aberrations including increased inflammation, increasing their cardiovascular risk…”
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Hyperglycemia induces Toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy by Kaur, Harmeet, Chien, Alexander, Jialal, Ishwarlal

“…Diabetes is a proinflammatory state. The pattern recognition receptors, Toll-like receptors (TLRs), are increased in diabetic patients and have been suggested…”
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Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes by Devaraj, Sridevi, Tobias, Peter, Jialal, Ishwarlal

“…► Diabetes is a pro-inflammatory state. ► Toll like receptors 2 and 4 are increased in diabetes. ► Knockout of TLR4 attenuates inflammation in diabetic rats. ►…”
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Toll-like receptors 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyx by Pahwa, Roma, Nallasamy, Palanisamy, Jialal, Ishwarlal

“…Abstract Objectives Hyperglycemia-induced inflammation is central to the vascular complications in diabetes. Toll-like receptors (TLRs) are key players in…”
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The Evolving Role of C-Reactive Protein in Atherothrombosis by Devaraj, Sridevi, Singh, Uma, Jialal, Ishwarlal

“…Inflammation is pivotal in all phases of atherosclerosis. Among the numerous inflammatory biomarkers, the largest amount of published data supports a role for…”
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Amino acid levels in nascent metabolic syndrome: A contributor to the pro-inflammatory burden by Reddy, Priya, Leong, Joseph, Jialal, Ishwarlal

“…Metabolic Syndrome (MetS) is a cluster of cardio-metabolic risk factors characterized by low-grade inflammation which confers an increased risk for type 2…”
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Fetuin-A is also an adipokine by Jialal, Ishwarlal, Pahwa, Roma

“…Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of…”
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Increased Chemerin and Decreased Omentin-1 in Both Adipose Tissue and Plasma in Nascent Metabolic Syndrome by Jialal, Ishwarlal, Devaraj, Sridevi, Kaur, Harmeet, Adams-Huet, Beverley, Bremer, Andrew A

“…Context: Adipose tissue dysregulation causing aberrant adipokine secretion contributes toward the proinflammatory state of metabolic syndrome (MetS). However,…”
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Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin by Yun, Jung-Mi, Jialal, Ishwarlal, Devaraj, Sridevi

“…Diabetes is a proinflammatory state. We have previously shown increased monocyte proinflammatory cytokines in patients with Type 1 and Type 2 diabetes. High…”
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Hyperglycemia Induces Toll-Like Receptor-2 and -4 Expression and Activity in Human Microvascular Retinal Endothelial Cells: Implications for Diabetic Retinopathy by Rajamani, Uthra, Jialal, Ishwarlal

“…Diabetic retinopathy (DR) causes visual impairment in working age adults and hyperglycemia-mediated inflammation is central in DR. Toll-like receptors (TLRs)…”
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Increased mast cell abundance in adipose tissue of metabolic syndrome: relevance to the proinflammatory state and increased adipose tissue fibrosis by Gurung, Purnima, Moussa, Karine, Adams-Huet, Beverley, Devaraj, Sridevi, Jialal, Ishwarlal

“…Metabolic Syndrome (MetS) affects 35% of American adults > 40 yr and portends an increased risk for both atherosclerotic cardiovascular disease (ASCVD) and…”
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Adipose Tissue Dysfunction in Nascent Metabolic Syndrome by Bremer, Andrew A., Jialal, Ishwarlal

“…The metabolic syndrome (MetS) confers an increased risk for both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Moreover, studies on adipose…”
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Correlates of Insulin Resistance in Nascent Metabolic Syndrome by Adams-Huet, Beverley, Jialal, Ishwarlal

“…Background: Metabolic Syndrome (MetS), a major global problem, is a cluster of cardio-metabolic risk factors that predisposes to both type 2 diabetes mellitus…”
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Global toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy by Jialal, Ishwarlal, Major, Angela M, Devaraj, Sridevi

“…Abstract Background and purpose Type 1 diabetes mellitus (T1DM) is a pro-inflammatory state with increased toll-like receptor (TLR) activity. Inflammation is…”
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Modulating inflammation to reduce atherosclerotic cardiovascular events: should colchicine be part of the therapeutic regimen? by Jialal, Ishwarlal, Vikram, Naval

“…In a previous editorial in this journal we reviewed the large Canakinumab Anti-Inflammatory Thrombosis Outcome Study (CANTOS) and concluded based on the…”
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Increased adipose tissue secretion of Fetuin-A, lipopolysaccharide-binding protein and high-mobility group box protein 1 in metabolic syndrome by Jialal, Ishwarlal, Devaraj, Sridevi, Bettaieb, Ahmed, Haj, Fawaz, Adams-Huet, Beverley

“…Abstract Objective Adipose Tissue (AT) dysregulation contributes to the pro-inflammatory state and insulin resistance of Metabolic Syndrome (MetS). We examined…”
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