Search Results - "ISHIZUKA, Hitoshi"

Identification of Circulating miRNAs Differentially Regulated by Opioid Treatment by Toyama, Kaoru, Kiyosawa, Naoki, Watanabe, Kenji, Ishizuka, Hitoshi

“…Emerging evidence demonstrates functional contributions of microRNAs (miRNAs) to μ-opioid receptor (MOR) signaling, but the information so far has been mostly…”
Get full text

Single‐ and multiple‐dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects by Kato, Manabu, Furuie, Hidetoshi, Shimizu, Takako, Miyazaki, Atsuhiro, Kobayashi, Fumiaki, Ishizuka, Hitoshi

“…Aims To characterize the pharmacokinetics, pharmacodynamics and safety of esaxerenone, a mineralocorticoid receptor antagonist, in healthy adult Japanese men…”
Get full text

Circulating miRNA Signature as a Potential Biomarker for the Prediction of Analgesic Efficacy of Hydromorphone by Kiyosawa, Naoki, Watanabe, Kenji, Toyama, Kaoru, Ishizuka, Hitoshi

“…No practical biomarkers currently exist for the prediction of the analgesic efficacy of opioids. Previously, we reported circulating miRNA signatures…”
Get full text

Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment by Watanabe, Akiko, Ishizuka, Tomoko, Yamada, Makiko, Igawa, Yoshiyuki, Shimizu, Takako, Ishizuka, Hitoshi

“…Purpose Esaxerenone is a novel, oral, nonsteroidal treatment for hypertension. Physiologically based pharmacokinetic (PBPK) modelling was performed to predict…”
Get full text

Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment by Watanabe, Akiko, Ishizuka, Tomoko, Yamada, Makiko, Igawa, Yoshiyuki, Shimizu, Takako, Ishizuka, Hitoshi

Get full text

Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects by Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi

“…Aims To investigate the effects of the strong cytochrome P450 (CYP) 3A inhibitor itraconazole and the strong CYP3A inducer rifampicin on the pharmacokinetics…”
Get full text

Clinical Pharmacokinetics of Laninamivir, a Novel Long-Acting Neuraminidase Inhibitor, After Single and Multiple Inhaled Doses of Its Prodrug, CS-8958, in Healthy Male Volunteers by Ishizuka, Hitoshi, Yoshiba, Satoshi, Okabe, Hiromi, Yoshihara, Kazutaka

“…Phase 1 studies of laninamivir, a novel long‐acting neuraminidase inhibitor, were carried out to assess its safety, tolerability, and pharmacokinetics after…”
Get full text

Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects by Tachibana, Masaya, Matsuki, Shunji, Maekawa, Yutaro, Kuroda, Kana, Shimizu, Takako, Tsutsumi, Junko, Ishizuka, Hitoshi

“…Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of…”
Get full text

Intrapulmonary Distribution and Pharmacokinetics of Laninamivir, a Neuraminidase Inhibitor, after a Single Inhaled Administration of Its Prodrug, Laninamivir Octanoate, in Healthy Volunteers by ISHIZUKA, Hitoshi, TOYAMA, Kaoru, YOSHIBA, Satoshi, OKABE, Hiromi, FURUIE, Hidetoshi

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Model‐based assessments of CYP3A‐mediated drug‐drug interaction risk of milademetan by Hong, Ying, Ishizuka, Tomoko, Watanabe, Akiko, Tachibana, Masaya, Lee, Mark, Ishizuka, Hitoshi, LaCreta, Frank, Abutarif, Malaz

“…Milademetan is a small‐molecule inhibitor of murine double minute 2 (MDM2) that is in clinical development for advanced solid tumors and hematological cancers,…”
Get full text

Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study by Kurata, Akifumi, Furuie, Hidetoshi, Ishizuka, Tomoko, Nakatsu, Takafumi, Shimizu, Takako, Kato, Manabu, Nishikawa, Yasuhiro, Ishizuka, Hitoshi

“…Introduction To investigate the absolute bioavailability of esaxerenone and the effects of food on its pharmacokinetics (PK) after a single oral dose in…”
Get full text

A Randomized, Placebo‐Controlled, Double‐Blind Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Repeated Doses of Mirogabalin in Healthy Asian Volunteers by Jansen, Mendel, Warrington, Steven, Dishy, Victor, Ohwada, Shoichi, Johnson, Lisa, Brown, Karen, Ishizuka, Hitoshi

“…Mirogabalin is a novel, preferentially selective α2δ‐1 ligand under investigation to treat neuropathic pain. The purpose of this study was to evaluate the…”
Get full text

Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects by Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi

“…Abstract Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone…”
Get full text

Assessment of the Effects of Renal Impairment on the Pharmacokinetic Profile of Laninamivir, a Novel Neuraminidase Inhibitor, After a Single Inhaled Dose of Its Prodrug, CS-8958 by Ishizuka, Hitoshi, Yoshiba, Satoshi, Yoshihara, Kazutaka, Okabe, Hiromi

“…This open‐label, single‐dose study assessed the safety and pharmacokinetics of laninamivir, a new long‐acting neuraminidase inhibitor, after an inhaled 20‐mg…”
Get full text

Population Pharmacokinetics of Laninamivir and Its Prodrug Laninamivir Octanoate in Healthy Subjects and in Adult and Pediatric Patients with Influenza Virus Infection by Yoshihara, Kazutaka, Ishizuka, Hitoshi, Kubo, Yuichi

“…Laninamivir octanoate (LO) is a new neuraminidase inhibitor for inhalation. The objectives of this study were to model the population pharmacokinetics of LO…”
Get full text

Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure by Endo, Seiko, Fukahori, Aiko, Tokuhiro, Shinya, Shinagawa, Akira, Walker, Joseph, Yoshihara, Kazutaka, Ishizuka, Hitoshi, Ieiri, Ichiro, Sugiyama, Yuichi

“…It has been reported that organic anion-transporting polypeptide (OATP) 1B1, OATP1B3 and multidrug resistance-associated protein 2 are involved in the…”
Get full text

The Effects of External Heating on the Permeation of Oxybutynin through Human Epidermal Membrane by Mizushimaa, Haruhi, Inoue, Kazuhiro, Ishizuka, Hitoshi

“…The transdermal delivery system (TDS) of oxybutynin (OXY) is widely used for the treatment of overactive bladder patients. This report aimed to assess the…”
Get full text

Population Pharmacokinetics of Laninamivir and Its Prodrug Laninamivir Octanoate in Healthy Subjects and in Adult and Pediatric Patients with Influenza Virus Infection by Kazutaka YOSHIHARA, Hitoshi ISHIZUKA, Yuichi KUBO

“…[Summary]: Laninamivir octanoate (LO) is a new neuraminidase inhibitor for inhalation. The objectives of this study were to model the population…”
Get full text

Pharmacokinetics/Pharmacodynamics Analysis of the Relationship between the in Vivo Micturition Pressure and Receptor Occupancy of (R)-Oxybutynin and Its Metabolite in Rats by Mizushima, Haruhi, Kinoshita, Kazuya, Abe, Koji, Ishizuka, Hitoshi, Yamada, Yasuhiko

“…To elucidate the relationships between the pharmacokinetics and pharmacological effects of oxybutynin ((R/S)-OXY), the micturition pressure and the plasma…”
Get full text

Quantitative Evaluation of Effect of Renal Failure on the Pharmacokinetics of Panipenem in Rats by Tajima, Naoyuki, Soma, Masako, Ishizuka, Hitoshi, Naganuma, Hideo

“…The pharmacokinetics of panipenem in experimental renal failure animal models was investigated in order to identify the appropriate covariates affecting the…”
Get full text