Search Results - "ISHISAKI, AKIRA"

Zoledronic Acid Deteriorates Soft and Hard Tissue Healing of Murine Tooth Extraction Sockets in a Dose-Dependent Manner by Kozutsumi, Ryohei, Kuroshima, Shinichiro, Kaneko, Haruka, Sasaki, Muneteru, Ishisaki, Akira, Sawase, Takashi

“…The pathophysiology, histopathology, and immunopathology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) Stage 0 remain unclear. The aim of this…”
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Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice by Hayano, Hiroki, Kuroshima, Shinichiro, Sasaki, Muneteru, Tamaki, Saki, Inoue, Maaya, Ishisaki, Akira, Sawase, Takashi

“…There is limited information about denosumab-related osteonecrosis of the jaw (DRONJ), unlike bisphosphonate-related ONJ (BRONJ). The mode of action is clearly…”
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Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice by Tamaki, Saki, Kuroshima, Shinichiro, Hayano, Hiroki, Nakajima, Kazunori, Kakehashi, Hiroe, Ishisaki, Akira, Sawase, Takashi

“…Denosumab-related osteonecrosis of the jaw (DRONJ), which mainly occurs in cancer patients receiving anti-receptor activator NF-kappaB ligand (RANKL) antibody,…”
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Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell–cell adhesion through N-cadherin by Chosa, Naoyuki, Ishisaki, Akira

“…Mesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use…”
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Extracellular adenosine 5ʹ-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes by Yokota, Seiji, Chosa, Naoyuki, Matsumoto, Shikino, Satoh, Kazuro, Ishisaki, Akira

“…Background Temporomandibular joint osteoarthritis (TMJ-OA) causes cartilage degeneration, bone cavitation, and fibrosis of the TMJ. However, the mechanisms…”
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TGF‑β1 induces N‑cadherin expression by upregulating Sox9 expression and promoting its nuclear translocation in human oral squamous cell carcinoma cells by Hirano, Taifu, Saito, Daishi, Yamada, Hiroyuki, Ishisaki, Akira, Kamo, Masaharu

“…Squamous cell carcinoma (SCC) is the most frequent cancer that develops in the oral cavity. Epithelial-mesenchymal transition (EMT) is known to play an…”
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uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca2+/CaMKK/AMPK Axis by Kanno, Yosuke, Ishisaki, Akira, Kawashita, Eri, Kuretake, Hiromi, Ikeda, Kanako, Matsuo, Osamu

“…Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis-caused bone destruction, results from an increase of bone-resorbing osteoclasts…”
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Transforming growth factor-β1 induces invasion ability of HSC-4 human oral squamous cell carcinoma cells through the Slug/Wnt-5b/MMP-10 signalling axis by Hino, Masafumi, Kamo, Masaharu, Saito, Daishi, Kyakumoto, Seiko, Shibata, Toshiyuki, Mizuki, Harumi, Ishisaki, Akira

“…Molecular mechanism underlying the invasion of oral cancer cells remains to be clarified. We previously demonstrated that transforming growth factor-β1…”
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Hydrogen peroxide-induced oxidative stress promotes expression of CXCL15/Lungkine mRNA in a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint by Asanuma, Kanna, Yokota, Seiji, Chosa, Naoyuki, Kamo, Masaharu, Ibi, Miho, Mayama, Hisayo, Irié, Tarou, Satoh, Kazuro, Ishisaki, Akira

“…Temporomandibular joint osteoarthritis (TMJ-OA) is a multifactorial disease caused by inflammation and oxidative stress. It has been hypothesized that…”
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Enhancement of gingival inflammation induced by synergism of IL-1β and IL-6 by Sawada, Shunsuke, Chosa, Naoyuki, Ishisaki, Akira, Naruishi, Koji

“…Internleukin-1 (IL-1) and IL-6 are the most potent proinflammatory cytokines being involved in inflammatory diseases such as periodontitis. The objective of…”
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Transforming growth factor-β1 suppresses bone morphogenetic protein-2-induced mesenchymal-epithelial transition in HSC-4 human oral squamous cell carcinoma cells via Smad1/5/9 pathway suppression by Chiba, Takahiro, Ishisaki, Akira, Kyakumoto, Seiko, Shibata, Toshiyuki, Yamada, Hiroyuki, Kamo, Masaharu

“…Squamous cell carcinoma is the most common cancer in the oral cavity. We previously demonstrated that transforming growth factor-β1 (TGF-β1) promotes the…”
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Cell-cell interactions between monocytes/macrophages and synoviocyte-like cells promote inflammatory cell infiltration mediated by augmentation of MCP-1 production in temporomandibular joint by Ibi, Miho, Horie, Sawa, Kyakumoto, Seiko, Chosa, Naoyuki, Yoshida, Mariko, Kamo, Masaharu, Ohtsuka, Masato, Ishisaki, Akira

“…Many inflammatory cells are known to be home to inflamed temporomandibular joint (TMJ) tissues by stimulation with cytokines and chemokines produced by…”
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Transforming growth factor-β1 induces epithelial-mesenchymal transition and integrin α3β1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug by Saito, Daishi, Kyakumoto, Seiko, Chosa, Naoyuki, Ibi, Miho, Takahashi, Noriko, Okubo, Naoto, Sawada, Shunsuke, Ishisaki, Akira, Kamo, Masaharu

“…We investigated whether transforming growth factor (TGF)-β1 promoted epithelial-mesenchymal transition (EMT) and migration of human oral squamous cell…”
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α2-antiplasmin modulates bone formation by negatively regulating osteoblast differentiation and function by Kanno, Yosuke, Ishisaki, Akira, Kuretake, Hiromi, Maruyama, Chihiro, Matsuda, Ayaka, Matsuo, Osamu

“…α2-antiplasmin (α2AP) is known to be a physiological inhibitor of plasmin. Previously, we showed that α2AP displays various functions, such as promotion of…”
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Effects of apatite particle size in two apatite/collagen composites on the osteogenic differentiation profile of osteoblastic cells by HATAKEYAMA, WATARU, TAIRA, MASAYUKI, CHOSA, NAOYUKI, KIHARA, HIDEMICHI, ISHISAKI, AKIRA, KONDO, HISATOMO

“…The development of new osteoconductive bone substitute materials is expected in medicine. In this study, we attempted to produce new hydroxylapatite…”
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Water-soluble factors eluated from surface pre-reacted glass-ionomer filler promote osteoblastic differentiation of human mesenchymal stem cells by Nemoto, Akira, Chosa, Naoyuki, Kyakumoto, Seiko, Yokota, Seiji, Kamo, Masaharu, Noda, Mamoru, Ishisaki, Akira

“…Surface pre-reacted glass‑ionomer (S‑PRG)-containing dental materials, including composite and coating resins have been used for the restoration and/or…”
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ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint by Yokota, Seiji, Chosa, Naoyuki, Kyakumoto, Seiko, Kimura, Hitomichi, Ibi, Miho, Kamo, Masaharu, Satoh, Kazuro, Ishisaki, Akira

“…Malocclusion caused by abnormal jaw development or muscle overuse during mastication results in abnormal mechanical stress to the tissues surrounding the…”
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EGF Positively Regulates the Proliferation and Migration, and Negatively Regulates the Myofibroblast Differentiation of Periodontal Ligament-Derived Endothelial Progenitor Cells through MEK/ERK- and JNK-Dependent Signals by Kimura, Hitomichi, Okubo, Naoto, Chosa, Naoyuki, Kyakumoto, Seiko, Kamo, Masaharu, Miura, Hiroyuki, Ishisaki, Akira

“…Background/Aims: Remodeling of fibrous and vascular tissues in the periodontal ligament (PDL) around the tooth root was observed during tooth movement by…”
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Receptor tyrosine kinase ligands and inflammatory cytokines cooperatively suppress the fibrogenic activity in temporomandibular‑joint‑derived fibroblast‑like synoviocytes via mitogen‑activated protein kinase kinase/extracellular signal‑regulated kinase by Matsumoto, Shikino, Yokota, Seiji, Chosa, Naoyuki, Kyakumoto, Seiko, Kimura, Hitomichi, Kamo, Masaharu, Satoh, Kazuro, Ishisaki, Akira

“…Osteoarthritis (OA)-related fibrosis is a possible cause of temporomandibular joint (TMJ) stiffness. However, the molecular mechanisms underlying the…”
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uPA‐derived peptide, Å6 is involved in the suppression of lipopolysaccaride‐promoted inflammatory osteoclastogenesis and the resultant bone loss by Kanno, Yosuke, Maruyama, Chihiro, Matsuda, Ayaka, Ishisaki, Akira

“…Introduction Chronic inflammatory diseases such as rheumatoid arthritis and periodontitis frequently cause bone destruction. Inflammation‐induced bone loss…”
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