Search Results - "ISHIMOTO, Kenji"

Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy by Ishimoto, Kenji, Konishi, Yuma, Otani, Shuichi, Maeda, Soya, Ago, Yukio, Hino, Nobumasa, Suzuki, Masayuki, Nakagawa, Shinsaku

“…Food allergy is recognized as a global medical problem with increasing prevalence in recent years. Currently, the treatment of food allergy mainly involves…”
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Improved Bioavailability of β-Carotene by Amorphous Solid Dispersion Technology in Rats by OTANI, Shuichi, MIKI, Shohei, NAKAMURA, Yuta, ISHIMOTO, Kenji, AGO, Yukio, NAKAGAWA, Shinsaku

“…β-Carotene (BC) is a natural lipophilic carotenoid mainly present in vegetables and fruits. Although it has various beneficial pharmacological activities, its…”
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The Role of PPARs in Cancer by Doi, Takefumi, Ishimoto, Kenji, Yamasaki, Daisuke, Tachibana, Keisuke

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPARα…”
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Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders by Sakamoto, Kotaro, Chen, Lu, Miyaoka, Tatsunori, Yamada, Mei, Masutani, Teruaki, Ishimoto, Kenji, Hino, Nobumasa, Nakagawa, Shinsaku, Asano, Satoshi, Ago, Yukio

“…Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established…”
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The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation by Shirakura, Keisuke, Ishiba, Ryosuke, Kashio, Taito, Funatsu, Risa, Tanaka, Toru, Fukada, So-Ichiro, Ishimoto, Kenji, Hino, Nobumasa, Kondoh, Masuo, Ago, Yukio, Fujio, Yasushi, Yano, Kiichiro, Doi, Takefumi, Aird, William C, Okada, Yoshiaki

“…Roundabout guidance receptor 4 (Robo4) is an endothelial cell-specific receptor that stabilizes the vasculature in pathological angiogenesis. Although Robo4…”
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Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists by Miyachi, Hiroyuki, Yuzuriha, Tomohiro, Tabata, Ryotaro, Fukuda, Syohei, Nunomura, Kazuto, Lin, Bangzhong, Kobayashi, Tadayuki, Ishimoto, Kenji, Doi, Takefumi, Tachibana, Keisuke

“…[Display omitted] We previously reported that 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivative 6 is an agonist of human peroxisome…”
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Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives by Yoshida, Takuya, Oki, Hiroya, Doi, Michihiro, Fukuda, Syohei, Yuzuriha, Tomohiro, Tabata, Ryotaro, Ishimoto, Kenji, Kawahara, Kazuki, Ohkubo, Tadayasu, Miyachi, Hiroyuki, Doi, Takefumi, Tachibana, Keisuke

“…Small-molecule agonism of peroxisome proliferator-activated receptor α (PPARα), a ligand-activated transcriptional factor involved in regulating fatty acid…”
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Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity by Ishimoto, Kenji, Kawamata, Natsuko, Uchihara, Yoshie, Okubo, Moeka, Fujimoto, Reiko, Gotoh, Eiko, Kakinouchi, Keisuke, Mizohata, Eiichi, Hino, Nobumasa, Okada, Yoshiaki, Mochizuki, Yasuhiro, Tanaka, Toshiya, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Inoue, Tsuyoshi, Tachibana, Keisuke, Doi, Takefumi

“…Posttranslational modifications (PTMs) of proteins play a crucial role in regulating protein-protein interactions, enzyme activity, subcellular localization,…”
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Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion by Ishimoto, Kenji, Nakamura, Yuta, Otani, Shuichi, Miki, Shohei, Maeda, Soya, Iwamoto, Taiki, Konishi, Yuma, Ago, Yukio, Nakagawa, Shinsaku

“…β-Carotene (BC) has an antioxidant effect that removes active oxygen in vivo and can reduce the risk of developing various diseases, but it is almost insoluble…”
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ETV2-TET1/TET2 Complexes Induce Endothelial Cell-Specific Robo4 Expression via Promoter Demethylation by Tanaka, Toru, Izawa, Kohei, Maniwa, Yusuke, Okamura, Maki, Okada, Atsumasa, Yamaguchi, Tomoko, Shirakura, Keisuke, Maekawa, Naoki, Matsui, Hayato, Ishimoto, Kenji, Hino, Nobumasa, Nakagawa, Osamu, Aird, William C., Mizuguchi, Hiroyuki, Kawabata, Kenji, Doi, Takefumi, Okada, Yoshiaki

“…Although transcription factors regulating endothelial cell (EC)-specific gene expression have been identified, it is not known how those factors induce…”
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Analysis of the subcellular localization of the human histone methyltransferase SETDB1 by Tachibana, Keisuke, Gotoh, Eiko, Kawamata, Natsuko, Ishimoto, Kenji, Uchihara, Yoshie, Iwanari, Hiroko, Sugiyama, Akira, Kawamura, Takeshi, Mochizuki, Yasuhiro, Tanaka, Toshiya, Sakai, Juro, Hamakubo, Takao, Kodama, Tatsuhiko, Doi, Takefumi

“…SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase that methylates lysine 9 on histone H3. Although it is important to know the localization of…”
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Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion by Ishimoto, Kenji, Shimada, Yukiko, Ohno, Akane, Otani, Shuichi, Ago, Yukio, Maeda, Soya, Lin, Bangzhong, Nunomura, Kazuto, Hino, Nobumasa, Suzuki, Masayuki, Nakagawa, Shinsaku

“…Naringenin (NRG) is a plant-derived flavonoid. Due to its antioxidant, anti-inflammatory, and analgesic activities it is beneficial to human health and is…”
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Lipin 1 in Lipid Metabolism by ISHIMOTO, Kenji

“…The gene encoding lipin 1 was identified with a positional cloning approach that localized the causative mutation in fatty liver dystrophic (fld) mice, a mouse…”
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Tumor Necrosis Factor α Induces the Expression of the Endothelial Cell-Specific Receptor Roundabout4 through the Nuclear Factor-κB Pathway by Tanaka, Toru, Maekawa, Naoki, Kashio, Taito, Izawa, Kohei, Ishiba, Ryosuke, Shirakura, Keisuke, Ishimoto, Kenji, Hino, Nobumasa, Aird, William C., Doi, Takefumi, Okada, Yoshiaki

“…Roundabout4 (Robo4) is an endothelial cell-specific receptor that regulates vascular stability. Recently, Robo4 has been shown to regulate vascular…”
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Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome by Tachibana, Keisuke, Ishimoto, Kenji, Takahashi, Rika, Kadono, Hirokazu, Awaji, Takuya, Yuzuriha, Tomohiro, Tanaka, Toshiya, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Aoki, Shunji, Doi, Takefumi

“…Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily and include three subtypes (PPARα, PPARδ, and PPARγ)…”
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Expression of the Robo4 receptor in endothelial cells is regulated by two AP-1 protein complexes by Okada, Yoshiaki, Naruse, Hiroki, Tanaka, Toru, Funahashi, Nobuaki, Regan, Erzsébet Ravasz, Yamakawa, Kazuma, Hino, Nobumasa, Ishimoto, Kenji, Doi, Takefumi, Aird, William C.

“…Roundabout4 (Robo4) is an endothelial cell-specific gene that plays an important role in endothelial cell stability. We previously identified a 3-kb Robo4…”
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Sterol-mediated Regulation of Human Lipin 1 Gene Expression in Hepatoblastoma Cells by Ishimoto, Kenji, Nakamura, Hiroki, Tachibana, Keisuke, Yamasaki, Daisuke, Ota, Akemi, Hirano, Ken-ichi, Tanaka, Toshiya, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Doi, Takefumi

“…Lipin 1 plays a crucial role in lipid metabolism in adipose tissue, skeletal muscle, and liver. Its physiological role involves two cellular functions:…”
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Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis by Yamaguchi, Shiori, Yamane, Takuya, Takahashi-Niki, Kazuko, Kato, Izumi, Niki, Takeshi, Goldberg, Matthew S, Shen, Jie, Ishimoto, Kenji, Doi, Takefumi, Iguchi-Ariga, Sanae M M, Ariga, Hiroyoshi

“…DJ-1 is a novel oncogene and also causative gene for familial Parkinson's disease park7. DJ-1 has multiple functions that include transcriptional regulation,…”
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Endothelial Cell–Specific Expression of Roundabout 4 Is Regulated by Differential DNA Methylation of the Proximal Promoter by Okada, Yoshiaki, Funahashi, Nobuaki, Tanaka, Toru, Nishiyama, Yuji, Yuan, Lei, Shirakura, Keisuke, Turjman, Alexis S, Kano, Yoshihiro, Naruse, Hiroki, Suzuki, Ayano, Sakai, Miki, Zhixia, Jiang, Kitajima, Kenji, Ishimoto, Kenji, Hino, Nobumasa, Kondoh, Masuo, Mukai, Yohei, Nakagawa, Shinsaku, García-Cardeña, Guillermo, Aird, William C, Doi, Takefumi

“…OBJECTIVE—The molecular basis of endothelial cell (EC)–specific gene expression is poorly understood. Roundabout 4 (Robo4) is expressed exclusively in ECs. We…”
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Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element by Tachibana, Keisuke, Takeuchi, Kentaro, Inada, Hirohiko, Sugimoto, Ken, Ishimoto, Kenji, Yamashita, Masanori, Maegawa, Takashi, Yamasaki, Daisuke, Osada, Shigehiro, Tanaka, Toshiya, Rakugi, Hiromi, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Doi, Takefumi

“…Human mannose-binding lectin (MBL) is encoded by the MBL2 gene and is a key player in innate immunity. However, the mechanism of the transcriptional regulation…”
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