Search Results - "ISHII, HIDEE"

Activation of NLRP3 Inflammasome Complexes by Beta-Tricalcium Phosphate Particles and Stimulation of Immune Cell Migration in vivo by Maruyama, Kouji, Cheng, Jin-Yan, Ishii, Hidee, Takahashi, Yu, Zangiacomi, Vincent, Satoh, Takatomo, Hosono, Tetsuji, Yamaguchi, Ken

“…Beta-tricalcium phosphate (β-TCP) serves as a bone substitute in clinical practice because it is resorbable, biocompatible, osteointegrative, and…”
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A Fragrant Environment Containing α-Pinene Suppresses Tumor Growth in Mice by Modulating the Hypothalamus/Sympathetic Nerve/Leptin Axis and Immune System by Kusuhara, Masatoshi, Maruyama, Koji, Ishii, Hidee, Masuda, Yoko, Sakurai, Kazutoshi, Tamai, Eiko, Urakami, Kenichi

“…The environment is thought to affect outcomes in patients with cancer; however, this relationship has not been proven directly. Recently, an enriched…”
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Identification of a New Series of STAT3 Inhibitors by Virtual Screening by Matsuno, Kenji, Masuda, Yoshiaki, Uehara, Yutaka, Sato, Hiroshi, Muroya, Ayumu, Takahashi, Osamu, Yokotagawa, Takane, Furuya, Toshio, Okawara, Tadashi, Otsuka, Masami, Ogo, Naohisa, Ashizawa, Tadashi, Oshita, Chie, Tai, Sachiko, Ishii, Hidee, Akiyama, Yasuto, Asai, Akira

“…The signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for oncology drug development. We…”
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Fragrant environment with α-pinene decreases tumor growth in mice by Kusuhara, Masatoshi, Urakami, Kenichi, Masuda, Yoko, Zangiacomi, Vincent, Ishii, Hidee, Tai, Sachiko, Maruyama, Koj, Yamaguchi, Ken

“…Stress is believed to be harmful to not only mental but also physical health. However, proving a link between stress and disease is difficult. A recent study…”
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Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model by WAKABAYASHI-NAKAO, KANAKO, MARUYAMA, KOJI, ISHII, HIDEE, MURAMATSU, KOJI, HATAKEYAMA, KEIICHI, OHSHIMA, KEIICHI, OGURA, SHUN-ICHIRO, NAKAJIMA, TAKASHI, YAMAGUCHI, KEN, MOCHIZUKI, TOHRU

“…Proneurotensin/neuromedin N (proNT/NMN), the precursor of neurotensin (NT) and neuromedin N (NMN), is produced by cancer tissues derived from the pancreas and…”
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Effects of beta-tricalcium phosphate particles on primary cultured murine dendritic cells and macrophages by Tai, Sachiko, Cheng, Jin-Yan, Ishii, Hidee, Shimono, Kasumi, Zangiacomi, Vincent, Satoh, Takatomo, Hosono, Tetsuji, Suzuki, Emiko, Yamaguchi, Ken, Maruyama, Kouji

“…Beta-tricalcium phosphate (β-TCP) is widely used for bone substitution in clinical practice. Particles of calcium phosphate ceramics including β-TCP act as an…”
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Innate immunity and cancer therapy by Maruyama, Kouji, Selmani, Zohair, Ishii, Hidee, Yamaguchi, Ken

“…Classical cancer immunotherapy utilizes the immune response against microbial components, and a sequence of immune responses produce antitumor effects. The…”
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Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation by ASHIZAWA, Tadashi, MIYATA, Haruo, ASAI, Akira, AKIYAMA, Yasuto, ISHII, Hidee, OSHITA, Chie, MATSUNO, Kenji, MASUDA, Yoshiaki, FURUYA, Toshio, OKAWARA, Tadashi, OTSUKA, Masami, OGO, Naohisa

“…Signal transducer and activator of transcription (STAT)3, a member of a family of DNA-binding molecules mediating numerous physiological and oncogenic…”
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KW-4679, an antiallergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils by Ikemura, T, Manabe, H, Sasaki, Y, Ishii, H, Onuma, K, Miki, I, Kase, H, Sato, S, Kitamura, S, Ohmori, K

“…The effects of (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz [b.e.]oxepin-2-acetic acid monohydrochloride (KW-4679), an orally active antiallergic…”
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Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives by Ohshima, Etsuo, Otaki, Shizuo, Sato, Hideyuki, Kumazawa, Toshiaki, Obase, Hiroyuki, Ishii, Akio, Ishii, Hidee, Ohmori, Kenji, Hirayama, Noriaki

“…A new series of 11-substituted 6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid derivatives was synthesized and demonstrated to be orally active antiallergic…”
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Effects of KW-4679, a new orally active antiallergic drug, on antigen-induced bronchial hyperresponsiveness, airway inflammation and immediate and late asthmatic responses in guinea pigs by Ohmori, K, Ishii, H, Sasaki, Y, Ikemura, T, Manabe, H, Kitamura, S

“…We investigated the effects of KW-4679, an antiallergic drug, on the development of bronchial hyperresponsiveness, airway inflammation and early and late…”
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Characterization of beta-tricalcium phosphate as a novel immunomodulator by Tai, Sachiko, Cheng, Jin-Yan, Ishii, Hidee, Akimoto, Shingo, Satoh, Takatomo, Yamamoto, Kazumi, Nakajima, Takashi, Karaki, Sachiko, Suzuki, Emiko, Yamaguchi, Ken, Maruyama, Kouji

“…Calcium phosphate (CaP) ceramics including hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) have been widely used for bone substitution in orthopedic,…”
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Innate immunity and cancer therapy: Special Section: Immunopharmacology of Synthetic Natural Products by MARUYAMA, Kouji, SELMANI, Zohair, ISHII, Hidee, YAMAGUCHI, Ken

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Flt3 ligand enhances anti-tumor effects of antibody therapeutics by Maruyama, Kouji, Selmani, Zohair, Ishii, Hidee, Tai, Sachiko, Cheng, Jinyan, Akimoto, Shingo, Watanabe, Morihiro, Yamaguchi, Ken

“…Fms-like tyrosine kinase 3 ligand ([Flt3 ligand], FL) stimulates proliferation and development of a wide range of hematopoietic cells including hematopoietic…”
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Fragrant environment with [alpha]-pinene decreases tumor growth in mice by Kusuhara, Masatoshi, Urakami, Kenichi, Masuda, Yoko, Zangiacomi, Vincent, Ishii, Hidee, Tai, Sachiko, Maruyama, Koj, Yamaguchi, Ken

“…Stress is believed to be harmful to not only mental but also physical health. However, proving a link between stress and disease is difficult. A recent study…”
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Pharmacological studies on KW-4679, an antiallergic drug. (1): Inhibitory effect on passive cutaneous anaphylaxis (PCA) and experimental asthma in rats and guinea pigs by Ishii, H, Sasaki, Y, Ikemura, T, Kitamura, S, Ohmori, K

“…The present experiment was carried out to elucidate the antiallergic properties of KW-4679. Oral administration of KW-4679 showed a dose-dependent inhibition…”
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Effect of KW-4679, a novel antiallergic drug, on platelet-activating factor (PAF)-induced bronchoconstriction, airway hyperresponsiveness and pulmonary cell accumulation in guinea pigs by Sasaki, Y, Ikemura, T, Ishii, H, Kitamura, S, Ohmori, K

“…We assessed the effects of KW-4679 on bronchoconstriction, airway hyperresponsiveness and infiltration of inflammatory cells into the bronchoalveolar lavage…”
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A New Series of Antiallergic Agents. I. Synthesis and Activity of 11-(2-Aminoethyl)thio-6, 11-dihydrodibenz[b, e]oxepin Derivatives by OHSHIMA, Etsuo, KUMAZAWA, Toshiaki, TAKIZAWA, Hiroshi, HARAKAWA, Hiroyuki, SATO, Hideyuki, OBASE, Hiroyuki, OIJI, Yoshimasa, ISHII, Akio, ISHII, Hidee, OHMORI, Kenji

“…A new series of 11-substituted 6, 11-dihydrodibenz[b, e]oxepin derivatives was synthesized and evaluated for antiallergic activity. Convenient methods for the…”
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A New Series of Antiallergic Agents. II. Synthesis and Activity of New 6, 11-Dihydrodibenz[b, e]oxepin-carboxylic Acid Derivatives by KUMAZAWA, Toshiaki, OHSHIMA, Etsuo, HARAKAWA, Hiroyuki, SATO, Hideyuki, OBASE, Hiroyuki, OIJI, Yoshimasa, ISHII, Akio, ISHII, Hidee, OHMORI, Kenji

“…New methods for the preparation of multi-functionallized-6, 11-dihydrodibenz[b, e]oxepins were developed. The structural requirements of KW-4994 (1), a…”
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Inhibitory Effect of KW-4679, an Anti-allergic Drug, on Tachykinin-Mediated Airway Response Induced by Electric Vagal Stimulation in Guinea Pigs by Ikemura, Toshihide, Sasaki, Yasuo, Ishii, Hidee, Ohmori, Kenji

“…We examined the effect of KW-4679 ((Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride), an anti-allergic drug,…”
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