Search Results - "ISHIGURO, Masaji"

Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds by Masuda, Katsuyoshi, Koizumi, Ayako, Nakajima, Ken-ichiro, Tanaka, Takaharu, Abe, Keiko, Misaka, Takumi, Ishiguro, Masaji

“…One of the most distinctive features of human sweet taste perception is its broad tuning to chemically diverse compounds ranging from low-molecular-weight…”
Get full text

Identification of key amino acid residues in the hTGR5-nomilin interaction and construction of its binding model by Sasaki, Takashi, Mita, Moeko, Ikari, Naho, Kuboyama, Ayane, Hashimoto, Shuzo, Kaneko, Tatsuya, Ishiguro, Masaji, Shimizu, Makoto, Inoue, Jun, Sato, Ryuichiro

“…TGR5, a member of the G protein-coupled receptor (GPCR) family, is activated by bile acids. Because TGR5 promotes energy expenditure and improves glucose…”
Get full text

Structural Basis of pH Dependence of Neoculin, a Sweet Taste-Modifying Protein by Ohkubo, Takayuki, Tamiya, Minoru, Abe, Keiko, Ishiguro, Masaji

“…Among proteins utilized as sweeteners, neoculin and miraculin are taste-modifying proteins that exhibit pH-dependent sweetness. Several experiments on neoculin…”
Get full text

Crystal Structure of Squid Rhodopsin with Intracellularly Extended Cytoplasmic Region by Shimamura, Tatsuro, Hiraki, Kenji, Takahashi, Naoko, Hori, Tetsuya, Ago, Hideo, Masuda, Katsuyoshi, Takio, Koji, Ishiguro, Masaji, Miyano, Masashi

“…G-protein-coupled receptors play a key step in cellular signal transduction cascades by transducing various extracellular signals via G-proteins. Rhodopsin is…”
Get full text

Structure-activity relationships of GPR120 agonists based on a docking simulation by Sun, Qi, Hirasawa, Akira, Hara, Takafumi, Kimura, Ikuo, Adachi, Tetsuya, Awaji, Takeo, Ishiguro, Masaji, Suzuki, Takayoshi, Miyata, Naoki, Tsujimoto, Gozoh

“…GPR120 is a G protein-coupled receptor expressed preferentially in the intestinal tract and adipose tissue, that has been implicated in mediating free fatty…”
Get more information

Local Differentiation of Sugar Donor Specificity of Flavonoid Glycosyltransferase in Lamiales by Noguchi, Akio, Horikawa, Manabu, Fukui, Yuko, Fukuchi-Mizutani, Masako, Iuchi-Okada, Asako, Ishiguro, Masaji, Kiso, Yoshinobu, Nakayama, Toru, Ono, Eiichiro

“…Flavonoids are most commonly conjugated with various sugar moieties by UDP-sugar:glycosyltransferases (UGTs) in a lineage-specific manner. Generally, the…”
Get full text

Structural requirements of cholenamide derivatives as the LXR ligands by Saida–Tamiya, Kana, Tamiya, Minoru, Sekiya, Genki, Isobe, Kazunori, Kitazawa, Takaaki, Isaka, Nobuhisa, Matsukawa, Ayako, Kawahara, Kohichi, Komuro, Akihiko, Ishiguro, Masaji

“…[Display omitted] A study of the structural requirements of cholic acid derivatives as liver X receptor (LXR) ligands was performed. A model of cholenamide…”
Get full text

Metastable decomposition and hydrogen migration of ethane dication produced in an intense femtosecond near-infrared laser field by Hoshina, Kennosuke, Kawamura, Haruna, Tsuge, Masashi, Tamiya, Minoru, Ishiguro, Masaji

“…We investigated a formation channel of triatomic molecular hydrogen ions from ethane dication induced by irradiation of intense laser fields (800 nm, 100 fs,…”
Get more information

FFA1‐selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models by Takeuchi, Masato, Hirasawa, Akira, Hara, Takafumi, Kimura, Ikuo, Hirano, Tatsuya, Suzuki, Takayoshi, Miyata, Naoki, Awaji, Takeo, Ishiguro, Masaji, Tsujimoto, Gozoh

“…BACKGROUND AND PURPOSE The free fatty acid FFA1 receptor and GPR120 are GPCRs whose endogenous ligands are medium‐ and long‐chain FFAs, and they are important…”
Get full text

The Pseudomonas aeruginosa Autoinducer N-3-Oxododecanoyl Homoserine Lactone Accelerates Apoptosis in Macrophages and Neutrophils by TATEDA, Kazuhiro, ISHII, Yoshikazu, HORIKAWA, Manabu, MATSUMOTO, Tetsuya, MIYAIRI, Shinichi, PECHERE, Jean Claude, STANDIFORD, Theodore J, ISHIGURO, Masaji, YAMAGUCHI, Keizo

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Ligand-Binding Modes in Cationic Biogenic Amine Receptors by Ishiguro, Masaji

“…The binding site in G protein‐coupled cationic biogenic amine receptors is formed in the cleft of the seven transmembrane segments. Upon binding the ligand,…”
Get full text

Reminiscences of research on the chemistry and biology of natural sterols in insects, plants and humans by IKEKAWA, Nobuo, FUJIMOTO, Yoshinori, ISHIGURO, Masaji

“…Natural sterols often occur as a heterogeneous mixture of homologs, which had disturbed the progress of steroid research. Development and application of GC…”
Get full text

Total Synthesis of 2,6-Dideoxy-3-O-methylpyranosylillustrol, a Seco-norpregnaneglycoside from Mandevilla illustris by Tamiya, Minoru, Isaka, Nobuhisa, Ishizawa, Kazuya, Ikeda, Mayu, Ishiguro, Masaji

“…2,6-Dideoxy-3-O-methylpyranosylillustrol (3) was stereoselectively synthesized through the oxidative construction of a cage-like DEF ring moiety and…”
Get full text

A Concise Total Synthesis of the Non-peptide Bradykinin B1 Receptor Antagonist Velutinol A by Isaka, Nobuhisa, Tamiya, Minoru, Hasegawa, Atsushi, Ishiguro, Masaji

“…A concise route to the bradykinin B1 receptor antagonist velutinol A, a natural product isolated from the rhizomatous of mandevilla velutina (Apocynaceae), has…”
Get full text

Pseudomonas aeruginosa Las quorum sensing autoinducer suppresses growth and biofilm production in Legionella species by Kimura, Soichiro, Tateda, Kazuhiro, Ishii, Yoshikazu, Horikawa, Manabu, Miyairi, Shinichi, Gotoh, Naomasa, Ishiguro, Masaji, Yamaguchi, Keizo

“…1 Department of Microbiology and Infectious Diseases, Toho University Faculty of Medicine, Ota-ku, Tokyo 143-8540, Japan 2 Suntory Institute for Bioorganic…”
Get full text

Direct Interaction of Multidrug Efflux Transporter AcrB and Outer Membrane Channel TolC Detected via Site-Directed Disulfide Cross-Linking by Tamura, Norihisa, Murakami, Satoshi, Oyama, Yoshiaki, Ishiguro, Masaji, Yamaguchi, Akihito

“…The AcrAB−TolC system exports a wide variety of drugs and toxic compounds, and confers intrinsic drug tolerance on Escherichia coli. The crystal structures…”
Get full text

The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides by Sakurai, Takanobu, Misaka, Takumi, Ueno, Yohei, Ishiguro, Masaji, Matsuo, Shinji, Ishimaru, Yoshiro, Asakura, Tomiko, Abe, Keiko

“…► The bitterness of gentiobiose is mediated by activation of hTAS2R16. ► Only slight differences in sugar configuration can lead to the activation of different…”
Get full text

Mechanism of Inverse Agonist Action of Sarpogrelate at the Constitutively Active Mutant of Human 5-HT2A Receptor Revealed by Molecular Modeling by Hossain, Murad, Muntasir, Habib Abul, Ishiguro, Masaji, Bhuiyan, Mohiuddin Ahmed, Rashid, Mamunur, Sugihara, Takumichi, Nagatomo, Takafumi

“…We previously reported that sarpogrelate, a selective 5-HT2A antagonist, showed a potent inverse agonist activity to constitutively active mutant (C322K) of…”
Get full text

Enhanced Reactivity of Rhizopus oryzae Lipase Displayed on Yeast Cell Surfaces in Organic Solvents: Potential as a Whole-Cell Biocatalyst in Organic Solvents by Shiraga, Seizaburo, Kawakami, Masayuki, Ishiguro, Masaji, Ueda, Mitsuyoshi

“…Immobilization of enzymes on some solid supports has been used to stabilize enzymes in organic solvents. In this study, we evaluated applications of…”
Get full text

Identification by Comprehensive Chimeric Analysis of a Key Residue Responsible for High Affinity Glucose Transport by Yeast HXT2 by Kasahara, Toshiko, Maeda, Mari, Ishiguro, Masaji, Kasahara, Michihiro

“…Hxt2 and Hxt1 are, respectively, high affinity and low affinity facilitative glucose transporter paralogs of Saccharomyces cerevisiae. We have previously…”
Get full text