Search Results - "ISHIBASHI, Toshiyuki"

Global atmospheric state analysis using objective Gaussian probability density functions by Ishibashi, Toshiyuki

“…Atmospheric state analysis is a difficult scientific problem due to the chaotic nature of the atmosphere. Data assimilation is a framework for generating an…”
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Accurate Global Atmospheric State Analysis Using Objective Error Statistics Including Observation Error Dependence on Water Substance Field by Ishibashi, Toshiyuki

“…Atmospheric state analysis is a difficult scientific problem but essential for atmospheric sciences. Data assimilation can generate accurate analyses by…”
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Twin‐analysis verification: A new verification approach to alleviate pitfalls of own‐analysis verification by Hotta, Daisuke, Kadowaki, Takashi, Yonehara, Hitoshi, Ishibashi, Toshiyuki

“…In operational numerical weather prediction (NWP), forecast verification against analysis from the same experiment is part of the standard evaluation practice…”
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Tangent linear approximation based observation data impact estimation in 4D‐Var by Ishibashi, Toshiyuki

“…In variational data assimilation systems (variational DASs), the effect of each assimilated observation dataset on an analysis field is one of the main factors…”
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Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Coronary Heart Disease (PROSPECTIVE) by Yamashita, Shizuya, Arai, Hidenori, Bujo, Hideaki, Masuda, Daisaku, Ohama, Tohru, Ishibashi, Toshiyuki, Yanagi, Koji, Doi, Yasuji, Nakagawa, Satoshi, Yamashiro, Koichi, Tanabe, Kenichiro, Kita, Toru, Matsuzaki, Masunori, Saito, Yasushi, Fukushima, Masanori, Matsuzawa, Yuji, on Behalf of the PROSPECTIVE Study Group

“…Aims: Although intensive statin therapy reduced cardiovascular risks, cardiovascular events have not been completely prevented. Probucol is a potent…”
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Improvements in tropical precipitation and sea surface air temperature fields in a coupled atmosphere–ocean data assimilation system by Fujii, Yosuke, Ishibashi, Toshiyuki, Yasuda, Tamaki, Takaya, Yuhei, Kobayashi, Chiaki, Ishikawa, Ichiro

“…A coupled atmosphere–ocean data assimilation system, the Meteorological Research Institute‐Coupled Data Assimilation System Version 1 (MRI‐CDA1), was developed…”
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Comparison between febuxostat and allopurinol uric acid-lowering therapy in patients with chronic heart failure and hyperuricemia: a multicenter randomized controlled trial by Suzuki, Satoshi, Yoshihisa, Akiomi, Yokokawa, Tetsuro, Kobayashi, Atsushi, Yamaki, Takayoshi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Tsuda, Akihiro, Tsuda, Tatsunori, Ishibashi, Toshiyuki, Konno, Ichiro, Yamaguchi, Osamu, Machii, Hirofumi, Nozaki, Naoki, Niizeki, Takeshi, Miyamoto, Takuya, Takeishi, Yasuchika

“…Objective Heart failure (HF) is a common and highly morbid cardiovascular disorder. Oxidative stress worsens HF, and uric acid (UA) is a useful oxidative…”
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Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT by Arai, Hidenori, Bujo, Hideaki, Masuda, Daisaku, Ishibashi, Toshiyuki, Nakagawa, Satoshi, Tanabe, Kenichiro, Kagimura, Tatsuo, Kang, Hyun-Jae, Kim, Moo Hyun, Sung, Jidong, Kim, Sang-Hyun, Kim, Cheol-Ho, Park, Jeong Euy, Ge, Junbo, Oh, Byung-Hee, Kita, Toru, Saito, Yasushi, Fukushima, Masanori, Matsuzawa, Yuji, Yamashita, Shizuya

“…Aims: In this study, we integrated two randomized control trials, PROSPECTIVE and IMPACT, to address the effect of probucol on cerebrocardiovascular events and…”
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Receptor for advanced glycation end products - membrane type1 matrix metalloproteinase axis regulates tissue factor expression via RhoA and Rac1 activation in high-mobility group box-1 stimulated endothelial cells by Sugimoto, Koichi, Ohkawara, Hiroshi, Nakamura, Yuichi, Takuwa, Yoh, Ishibashi, Toshiyuki, Takeishi, Yasuchika

“…Atherosclerosis is understood to be a blood vessel inflammation. High-mobility group box-1 (HMGB-1) plays a key role in the systemic inflammation. Tissue…”
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LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells by Sugimoto, Koichi, Ishibashi, Toshiyuki, Sawamura, Tatsuya, Inoue, Nobutaka, Kamioka, Masashi, Uekita, Hironori, Ohkawara, Hiroshi, Sakamoto, Takayuki, Sakamoto, Nobuo, Okamoto, Yasuo, Takuwa, Yoh, Kakino, Akemi, Fujita, Yoshiko, Tanaka, Takeshi, Teramoto, Tamio, Maruyama, Yukio, Takeishi, Yasuchika

“…Aims RhoA and Rac1 activation plays a key role in endothelial dysfunction. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major receptor…”
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Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-α-induced procoagulant activity and apoptosis in endothelial cells by Ohkawara, Hiroshi, Ishibashi, Toshiyuki, Sugimoto, Koichi, Ikeda, Kazuhiko, Ogawa, Kazuei, Takeishi, Yasuchika

“…Membrane type 1-matrix metalloproteinase (MT1-MMP) functions as a signaling molecule in addition to a proteolytic enzyme. Our hypothesis was that MT1-MMP…”
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Feasibility Study for Future Space-Borne Coherent Doppler Wind Lidar, Part 3: Impact Assessment Using Sensitivity Observing System Simulation Experiments by OKAMOTO, Kozo, ISHIBASHI, Toshiyuki, ISHII, Shoken, BARON, Philippe, GAMO, Kyoka, TANAKA, Taichu Y., YAMASHITA, Koji, KUBOTA, Takuji

“…This study evaluated the impact of a future space-borne Doppler wind lidar (DWL) on a super-low-altitude orbit by using an observing system simulation…”
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Anti-atherosclerotic and anti-inflammatory effects of statin on cardiovascular disease and their mechanisms by Ishibashi, Toshiyuki

“…Inflammation plays a central role in the development of atherosclerosis and plaque rupture. Statin not only inhibits cholesterol synthesis but also elicits…”
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Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells by Sakamoto, Nobuo, Ishibashi, Toshiyuki, Sugimoto, Koichi, Sawamura, Tatsuya, Sakamoto, Takayuki, Inoue, Nobutaka, Saitoh, Shu-ichi, Kamioka, Masashi, Uekita, Hironori, Ohkawara, Hiroshi, Suzuki, Koji, Teramoto, Tamio, Maruyama, Yukio, Takeishi, Yasuchika

“…This study was conducted to examine the role of lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) in monocyte adhesion‐induced redox‐sensitive,…”
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Ezetimibe and vascular inflammation by Ishibashi, Toshiyuki, Takeishi, Yasuchika

“…Atherosclerosis is an inflammation-based complex vascular disorder which causes coronary artery disease, stroke and peripheral artery disease. Its…”
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Integral role of receptor for advanced glycation end products (RAGE) in nondiabetic atherosclerosis by Uekita, Hironori, Ishibashi, Toshiyuki, Shiomi, Masashi, Koyama, Hidenori, Ohtsuka, Shukuko, Yamamoto, Hiroshi, Yamagishi, Shoichi, Inoue, Hiroyoshi, Itabe, Hiroyuki, Sugimoto, Koichi, Kamioka, Masashi, Ohkawara, Hiroshi, Wada, Ikuo, Yasuchika, Takeishi

“…An advanced glycation end products (AGE)/a receptor for AGE (RAGE) axis plays a central role in the pathogenesis of diabetic vascular remodeling. This study…”
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Blockade of Renin-Angiotensin System Attenuates Advanced Glycation End Products-Mediated Signaling Pathways by Kamioka, Masashi, Ishibashi, Toshiyuki, Sugimoto, Koichi, Uekita, Hironori, Nagai, Ryoji, Sakamoto, Nobuo, Ando, Katsuya, Ohkawara, Hiroshi, Teramoto, Tamio, Maruyama, Yukio, Takeishi, Yasuchika

“…Aim: Advanced glycation end products (AGE) and a receptor for AGE (RAGE) play a key role in diabetic vascular complications. Matrix metalloproteinases (MMPs)…”
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Involvement of membrane type 1-matrix metalloproteinase (MT1-MMP) in RAGE activation signaling pathways by Kamioka, Masashi, Ishibashi, Toshiyuki, Ohkawara, Hiroshi, Nagai, Ryoji, Sugimoto, Koichi, Uekita, Hironori, Matsui, Takanori, Yamagishi, Sho-Ichi, Ando, Katsuya, Sakamoto, Takayuki, Sakamoto, Nobuo, Takuwa, Yoh, Wada, Ikuo, Shiomi, Masashi, Maruyama, Yukio, Takeishi, Yasuchika

“…An advanced glycation end products (AGE)/a receptor for AGE (RAGE) axis plays a key role in diabetic vascular complications. Membrane type 1‐matrix…”
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Reply to Letter to the Editor by Uekita, Hironori, MD, PhD, Ishibashi, Toshiyuki, MD, PhD

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Advanced Glycation End Product-Mediated Matrix Metallo-proteinase-9 and Apoptosis via Renin-Angiotensin System in Type 2 Diabetes by Ishibashi, Toshiyuki, Kawaguchi, Michiko, Sugimoto, Koichi, Uekita, Hironori, Sakamoto, Nobuo, Yokoyama, Keiko, Maruyama, Yukio, Takeishi, Yasuchika

“…Aim: Advanced glycation end products (AGE) play a key role in diabetic vascular complications, whereas matrix metalloproteinases (MMPs) and apoptosis…”
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