Search Results - "ISEKI, KEN"

Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4) by Kobayashi, Masaki, Narumi, Katsuya, Furugen, Ayako, Iseki, Ken

“…Human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4) are involved in the proton-dependent transport of monocarboxylates such as L-lactate, which play an…”
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In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid by Sato, Yuki, Itagaki, Shirou, Kurokawa, Toshimitsu, Ogura, Jiro, Kobayashi, Masaki, Hirano, Takeshi, Sugawara, Mitsuru, Iseki, Ken

“…Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid…”
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MicroRNA-101-5p Suppresses the Expression of the Ras-Related Protein RAP1A by Shibayama, Yoshihiko, Kubo, Yoshitada, Nakagawa, Tsutomu, Iseki, Ken

“…MicroRNAs (miRs) are small, non-coding RNAs that negatively regulate gene expression. The stem-loop sequence miR-101-1 generates mature miR-101-5p and…”
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Validation of the usefulness of artificial neural networks for risk prediction of adverse drug reactions used for individual patients in clinical practice by Imai, Shungo, Takekuma, Yoh, Kashiwagi, Hitoshi, Miyai, Takayuki, Kobayashi, Masaki, Iseki, Ken, Sugawara, Mitsuru

“…Artificial neural networks are the main tools for data mining and were inspired by the human brain and nervous system. Studies have demonstrated their…”
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Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells by Nadai, Takanobu, Narumi, Katsuya, Furugen, Ayako, Saito, Yoshitaka, Iseki, Ken, Kobayashi, Masaki

“…The rate of glycolysis in cancer cells is higher than that of normal cells owing to high energy demands, which results in the production of excess lactate…”
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Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na+-sensitive creatine transporter by Futagi, Yuya, Narumi, Katsuya, Furugen, Ayako, Kobayashi, Masaki, Iseki, Ken

“…Human monocarboxylate transporters (hMCTs) mediate the transport of monocarboxylates across plasma membranes. One such transporter, hMCT9, has been shown to be…”
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Evaluation of Daptomycin-Induced Cellular Membrane Injury in Skeletal Muscle by Yamada, Takehiro, Ishikawa, Shuhei, Ishiguro, Nobuhisa, Kobayashi, Masaki, Iseki, Ken

“…Daptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms and is especially effective against…”
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Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4) by Futagi, Yuya, Kobayashi, Masaki, Narumi, Katsuya, Furugen, Ayako, Iseki, Ken

“…Human monocarboxylate transporters (hMCTs/SLC16As) mediate the transport of monocarboxylic compounds across plasma membranes. Among the hMCTs, hMCT1 and hMCT4…”
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Different mechanisms of cisplatin resistance development in human lung cancer cells by Okamoto, Keisuke, Saito, Yoshitaka, Narumi, Katsuya, Furugen, Ayako, Iseki, Ken, Kobayashi, Masaki

“…Cisplatin (CDDP) is a highly potent and important anticancer drug in lung cancer treatment. Long-term use of an anticancer agent causes resistance in cancer…”
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Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4 by Yamaguchi, Atsushi, Narumi, Katsuya, Furugen, Ayako, Iseki, Ken, Kobayashi, Masaki

“…Human monocarboxylate transporters (hMCTs) 1–4 transport monocarboxylates, such as l-lactate and pyruvate, as well as H+ across the plasma membrane. hMCT1, 2,…”
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Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin by SUZUKI, Takahiro, YAMAGUCHI, Hiroaki, OGURA, Jiro, KOBAYASHI, Masaki, YAMADA, Takehiro, LSEKI, Ken

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Functional Characterization of 5-Oxoproline Transport via SLC16A1/MCT1 by Sasaki, Shotaro, Futagi, Yuya, Kobayashi, Masaki, Ogura, Jiro, Iseki, Ken

“…Thyrotropin-releasing hormone is a tripeptide that consists of 5-oxoproline, histidine, and proline. The peptide is rapidly metabolized by various enzymes…”
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Anticancer effects of non-steroidal anti-inflammatory drugs against cancer cells and cancer stem cells by Okamoto, Keisuke, Saito, Yoshitaka, Narumi, Katsuya, Furugen, Ayako, Iseki, Ken, Kobayashi, Masaki

“…Certain non-steroidal anti-inflammatory drugs (NSAIDs) are known to have anticancer effects. However, it is unclear whether all NSAIDs have anticancer effects,…”
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Traumatic pneumorrhachis associated with cerebral fluid leakage evaluated with magnetic resonance myelography by Sugaya, Kazuki, Iseki, Ken

“…Attention should be paid to cerebrospinal fluid leakage in patients with pneumorrhachis associated with vertebral body trauma. If pneumorrhachis is detected,…”
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Usefulness of a decision tree model for the analysis of adverse drug reactions: Evaluation of a risk prediction model of vancomycin‐associated nephrotoxicity constructed using a data mining procedure by Imai, Shungo, Yamada, Takehiro, Kasashi, Kumiko, Kobayashi, Masaki, Iseki, Ken

“…Objectives Several publications concerning decision tree (DT) analysis in medical fields have recently demonstrated its usefulness for defining prognostic…”
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Regulation of Chloride Channels by Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced α-Defensin 5 by Uemura, Ippei, Takahashi-Suzuki, Natsuko, Kita, Fumiya, Kobayashi, Masaki, Yamada, Takehiro, Iseki, Ken, Satoh, Takashi

“…Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used to treat non-small cell lung cancer with EGFR mutations. However,…”
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Analysis of α-Defensin 5 Secretion in Differentiated Caco-2 Cells: Comparison of Cell Bank Origin by Yasuda, Genki, Kobayashi, Masaki, Kubota, Atsuhito, Narumi, Katsuya, Furugen, Ayako, Saito, Yoshitaka, Satoh, Takashi, Suzuki, Natsuko, Iseki, Ken

“…α-Defensin 5 has a particularly broad antibacterial spectrum; it eliminates pathogenic microorganisms and regulates intestinal flora. Although Caco-2 cells are…”
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Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity by Kubota, Atsuhito, Kobayashi, Masaki, Sarashina, Sota, Takeno, Reiko, Yasuda, Genki, Narumi, Katsuya, Furugen, Ayako, Takahashi-Suzuki, Natsuko, Iseki, Ken

“…The aims of this study were to determine the effects of gamma-aminobutyric acid (GABA) on immunoglobulin A (IgA) secretion from Peyer’s patch (PP) cells; to…”
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Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP by Narumi, Katsuya, Ohata, Tsukika, Horiuchi, Yuichi, Satoh, Hiroshi, Furugen, Ayako, Kobayashi, Masaki, Iseki, Ken

“…2'-Deoxyadenosine 5'-monophosphate (dAMP), a deoxyribonucleotide found in DNA, affects intestinal cell growth. The molecular mechanisms underlying…”
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Necessity for a Significant Maintenance Dosage Reduction of Voriconazole in Patients with Severe Liver Cirrhosis (Child–Pugh Class C) by Yamada, Takehiro, Imai, Shungo, Koshizuka, Yasuyuki, Tazawa, Yuki, Kagami, Keisuke, Tomiyama, Naoki, Sugawara, Ryosuke, Yamagami, Akira, Shimamura, Tsuyoshi, Iseki, Ken

“…Therapeutic drug monitoring for voriconazole, an antifungal agent, is essential for maximizing efficacy and preventing toxicity. The aim of this study was to…”
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