Search Results - "ISACCHI, A"

A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response by Gambardella, G., Viscido, G., Tumaini, B., Isacchi, A., Bosotti, R., di Bernardo, D.

“…Cancer cells within a tumour have heterogeneous phenotypes and exhibit dynamic plasticity. How to evaluate such heterogeneity and its impact on outcome and…”
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NMS-P088, a CSF-1R, FLT3 and KIT inhibitor with outstanding activity on gatekeeper resistance mutations, high tolerability, and potential for combination therapies by Ardini, E, Lombardi Borgia, A, Texido, G, Alzani, R, Avanzi, N, Amboldi, N, Cribioli, S, Mancini, L, Casero, D, Pastori, W, Montemartini, M, Montagnoli, A, Donati, D, Galvani, A, Isacchi, A, Ciomei, M

“…CSF1R, FLT3 and KIT belong to the class III receptor tyrosine kinase family. Mutations or deletions in the autoinhibitory juxtamembrane (JM) domain region…”
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PATRI, a Genomics Data Integration Tool for Biomarker Discovery by Callari, Maurizio, Cesarini, M., Della Vedova, G., Daidone, Maria Grazia, Pettenella, M., Isacchi, A., Bosotti, R., Leone, A., Vescovi, M., Pirchio, M. R., Di Bella, S., Rossi, P., Raddrizzani, L., Melloni, G. E. M., Ukmar, G., Somaschini, A.

“…The availability of genomic datasets in association with clinical, phenotypic, and drug sensitivity information represents an invaluable source for potential…”
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517 Identification and characterization of selective MELK kinase inhibitors by Carpinelli, P, Amboldi, N, Ballinari, D, Re Depaolini, S, Cucchi, U, Canevari, G, Caruso, M, Galli, R, Donati, D, Isacchi, A, Felder, E.R, Montagnoli, A, Galvani, A

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309 Characterization of a Novel, Highly Potent and Selective RET Inhibitor with Antitumor Efficacy in RET Dependent Models by Ardini, E, Amboldi, N, Avanzi, N, Banfi, P, Cristiani, C, Donati, D, Galvani, A, Isacchi, A, Pesenti, E, Menichincheri, M

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231 A Novel siRNA Screening Approach for Target Identification in Oncology: Focus On Purinome Enzymes by Gasparri, F, Carugo, A, Galvani, A, Gianellini, L.M, Giorgini, M.L, Isacchi, A, Lupi, R, Perrera, C, Raddrizzani, L, Colombo, R

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Tyrosine 319, a Newly Identified Phosphorylation Site of ZAP-70, Plays a Critical Role in T Cell Antigen Receptor Signaling by Di Bartolo, V, Mège, D, Germain, V, Pelosi, M, Dufour, E, Michel, F, Magistrelli, G, Isacchi, A, Acuto, O

“…Following T cell antigen receptor (TCR) engagement, the protein tyrosine kinase (PTK) ZAP-70 is rapidly phosphorylated on several tyrosine residues, presumably…”
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Thermodynamics of the high-affinity interaction of TCF4 with β-catenin by Knapp, S, Zamai, M, Volpi, D, Nardese, V, Avanzi, N, Breton, J, Plyte, S, Flocco, M, Marconi, M, Isacchi, A, Caiolfa, V.R

“…The formation of a complex between β-catenin and members of the TCF/LEF family of high-mobility group proteins is a key regulatory event in the wnt-signaling…”
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Early Th1 Response in Unprimed Nonobese Diabetic Mice to the Tyrosine Phosphatase-Like Insulinoma-Associated Protein 2, an Autoantigen in Type 1 Diabetes by Trembleau, Sylvie, Penna, Giuseppe, Gregori, Silvia, Magistrelli, Giovanni, Isacchi, Antonella, Adorini, Luciano

“…The insulinoma-associated protein 2 (IA-2) is a phosphatase-like autoantigen inducing T and B cell responses associated with human insulin-dependent diabetes…”
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147 Pharmacological characterization of NMS-P506, a novel second generation HSP90 inhibitor by Fogliatto, G, Mantegani, S, Amboldi, N, Ponti, A. De, Gianellini, L, Guanci, M, Paolucci, M, Donati, D, Pesenti, E, Isacchi, A

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102 Identification and preclinical characterization of NMS-P626, a potent, selective and orally bioavailable TrkA inhibitor with anti-tumor activity in a TrkA-dependent colorectal cancer by Ardini, E, Borgia, A. Lombardi, Ponti, C. De, Amboldi, N, Ballinari, D, Saccardo, M.B, Magnaghi, P, Pesenti, E, Isacchi, A, Galvani, A

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136 Activity of the Cdc7 inhibitor NMS-1116354 as single agent and in combination in breast cancer models by Montagnoli, A, Ballinari, D, Ciavolella, A, Rainoldi, S, Menichincheri, M, Pesenti, E, Galvani, A, Isacchi, A, Moll, J

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385 A first in human phase 1 study of the safety and pharmacokinetics of a novel Cdc7 inhibitor NMS-1116354, administered orally to patients with solid tumors by Papadopoulos, K, Crippa, S, Hanssen, A, Montagnoli, A, Fiorentini, F, Tolcher, A.W, Martignoni, M, Isacchi, A, Laffranchi, B, Patnaik, A

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NMS-173, a potent, covalent second generation IDH1/IDH2 inhibitor by Magnaghi, P., Casuscelli, F., Ardini, E., Parazzoli, A., Troiani, S., Valsasina, B., Texido, G., Casale, E., Avanzi, N., Orsini, P., Nuvoloni, S., Salom, B., Lombardi Borgia, A., Salsi, E., Saturno, G.S., Re Depaolini, S., Stellato, C., Montagnoli, A., Galvani, A., Isacchi, A.

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NMS-01940153E, an MPS1 inhibitor with anti-tumor activity in relapsed or refractory unresectable Hepatocellular carcinoma by Reig, M., Damian, S., Roberti, D., Maruzzelli, S., Crivori, P., Gianellini, L., De Pietro, M.T., Personeni, N., Sanduzzi-Zamparelli, M., Duca, M., Disconzi, L., Montagnoli, A., Galvani, A., Ardini, E., Isacchi, A., Colajori, E., Davite, C., Mahnke, L., Rimassa, L.

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Expression of PTP35, the Murine Homolog of the Protein Tyrosine Phosphatase-Related Sequence IA-2, Is Regulated during Cell Growth and Stimulated by Mitogens in 3T3 Fibroblasts by Magistrelli, G., Covini, N., Mosca, M., Lippoli, G., Isacchi, A.

“…Protein tyrosine phosphatases (PTPases) have been implicated in the control of cell proliferation and differentiation. To isolate new members of this family…”
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FAT: a novel domain in PIK-related kinases by Bosotti, R, Isacchi, A, Sonnhammer, E L

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A Six-Amino Acid Deletion in Basic Fibroblast Growth Factor Dissociates its Mitogenic Activity from its Plasminogen Activator-Inducing Capacity by Isacchi, Antonella, Statuto, Massimo, Chiesa, Roberta, Bergonzoni, Laura, Rusnati, Marco, Sarmientos, Paolo, Ragnotti, Giovanni, Presta, Marco

“…A recombinant deletion mutant of the 155-amino acid form of human basic fibroblast growth factor (bFGF), lacking amino acid residues 27-32…”
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Basic fibroblast growth factor in Dupuytren's contracture by Gonzalez, AM, Buscaglia, M, Fox, R, Isacchi, A, Sarmientos, P, Farris, J, Ong, M, Martineau, D, Lappi, DA, Baird, A

“…Lesions excised from nine patients undergoing surgery for Dupuytren's contracture (DC) and three normal fascia were examined for the presence of the angiogenic…”
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388 - NMS-P088, a CSF-1R, FLT3 and KIT inhibitor with outstanding activity on gatekeeper resistance mutations, high tolerability, and potential for combination therapies by Ardini, E., Lombardi Borgia, A., Texido, G., Alzani, R., Avanzi, N., Amboldi, N., Cribioli, S., Mancini, L., Casero, D., Pastori, W., Montemartini, M., Montagnoli, A., Donati, D., Galvani, A., Isacchi, A., Ciomei, M.

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