Search Results - "ISAACS, William"

Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer by RONG HU, CHANGXUE LU, PLYMATE, Stephen R, JUN LUO, MOSTAGHEL, Elahe A, YEGNASUBRAMANIAN, Srinivasan, GUREL, Meltem, TANNAHILL, Clare, EDWARDS, Joanne, ISAACS, William B, NELSON, Peter S, BLUEMN, Eric

“…Continued androgen receptor (AR) signaling is an established mechanism underlying castration-resistant prostate cancer (CRPC), and suppression of androgen…”
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Understanding the Mechanisms of Androgen Deprivation Resistance in Prostate Cancer at the Molecular Level by Karantanos, Theodoros, Evans, Christopher P, Tombal, Bertrand, Thompson, Timothy C, Montironi, Rodolfo, Isaacs, William B

“…Abstract Context Various molecular mechanisms play a role in the development of resistance to androgen deprivation therapy in castration-resistant prostate…”
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Incorporation of Polygenic Risk Score into Guidelines for Inherited Risk Assessment for Prostate Cancer by Xu, Jianfeng, Isaacs, William B.

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AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer by Antonarakis, Emmanuel S, Lu, Changxue, Wang, Hao, Luber, Brandon, Nakazawa, Mary, Roeser, Jeffrey C, Chen, Yan, Mohammad, Tabrez A, Chen, Yidong, Fedor, Helen L, Lotan, Tamara L, Zheng, Qizhi, De Marzo, Angelo M, Isaacs, John T, Isaacs, William B, Nadal, Rosa, Paller, Channing J, Denmeade, Samuel R, Carducci, Michael A, Eisenberger, Mario A, Luo, Jun

“…Enzalutamide and abiraterone target the androgen receptor and androgen synthesis and are used to treat castration-resistant prostate cancer. A splice variant…”
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Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide by Antonarakis, Emmanuel S., Lu, Changxue, Luber, Brandon, Liang, Chao, Wang, Hao, Chen, Yan, Silberstein, John L., Piana, Danilo, Lai, Zhao, Chen, Yidong, Isaacs, William B., Luo, Jun

“…Inherited DNA-repair gene mutations are more prevalent in men with advanced prostate cancer than previously thought, but their clinical implications are not…”
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A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities by Hu, Rong, Isaacs, William B., Luo, Jun

“…BACKGROUND The diversity and complexity of the human androgen receptor (AR) splicing variants are well appreciated but not fully understood. The goal of this…”
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Aggravated Androgen Receptor Activity in Otherwise Indolent Prostate Cancer by Lupold, Shawn E., Isaacs, William B., Luo, Jun

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Germline Mutations in ATM and BRCA1/2 Are Associated with Grade Reclassification in Men on Active Surveillance for Prostate Cancer by Carter, H. Ballentine, Helfand, Brian, Mamawala, Mufaddal, Wu, Yishuo, Landis, Patricia, Yu, Hongjie, Wiley, Kathleen, Na, Rong, Shi, Zhuqing, Petkewicz, Jacqueline, Shah, Sameep, Fantus, Richard J., Novakovic, Kristian, Brendler, Charles B., Zheng, S. Lilly, Isaacs, William B., Xu, Jianfeng

“…Mutations in DNA repair genes are associated with aggressive prostate cancer (PCa). To assess whether germline mutations are associated with grade…”
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Tracking the clonal origin of lethal prostate cancer by Haffner, Michael C, Mosbruger, Timothy, Esopi, David M, Fedor, Helen, Heaphy, Christopher M, Walker, David A, Adejola, Nkosi, Gürel, Meltem, Hicks, Jessica, Meeker, Alan K, Halushka, Marc K, Simons, Jonathan W, Isaacs, William B, De Marzo, Angelo M, Nelson, William G, Yegnasubramanian, Srinivasan

“…Recent controversies surrounding prostate cancer overtreatment emphasize the critical need to delineate the molecular features associated with progression to…”
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Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer by Lotan, Tamara L., Kaur, Harsimar B., Salles, Daniela C., Murali, Sanjana, Schaeffer, Edward M., Lanchbury, Jerry S., Isaacs, William B., Brown, Robert, Richardson, Andrea L., Cussenot, Olivier, Cancel-Tassin, Geraldine, Timms, Kirsten M., Antonarakis, Emmanuel S.

“…The homologous recombination deficiency (HRD) score integrates three DNA-based measures of genomic instability, and has been understudied in prostate cancer…”
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Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma by TAN, Hsueh-Li, AKSHAY SOOD, WENNUAN LIU, ISAACS, William B, DE MARZO, Angelo M, LOTAN, Tamara L, RAHIMI, Hameed A, WENLE WANG, GUPTA, Nilesh, HICKS, Jessica, MOSIER, Stacy, GOCKE, Christopher D, EPSTEIN, Jonathan I, NETTO, George J

“…Small cell neuroendocrine carcinoma of the prostate is likely to become increasingly common with recent advances in pharmacologic androgen suppression. Thus,…”
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Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer by RONG HU, DUNN, Thomas A, BOVA, G. Steven, JUN LUO, SHUANZENG WEI, ISHARWAL, Sumit, VELTRI, Robert W, HUMPHREYS, Elizabeth, HAN, Misop, PARTIN, Alan W, VESSELLA, Robert L, ISAACS, William B

“…Suppression of androgen production and function provides palliation but not cure in men with prostate cancer (PCa). Therapeutic failure and progression to…”
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Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA‐repair gene mutations in prostate cancer by Isaacsson Velho, Pedro, Silberstein, John L., Markowski, Mark C., Luo, Jun, Lotan, Tamara L., Isaacs, William B., Antonarakis, Emmanuel S.

“…Background Germline mutations in genes mediating DNA repair are common in men with recurrent and advanced prostate cancer, and their presence may alter…”
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Constitutively active androgen receptor splice variants AR-V3, AR-V7 and AR-V9 are co-expressed in castration-resistant prostate cancer metastases by Kallio, Heini M. L., Hieta, Reija, Latonen, Leena, Brofeldt, Anniina, Annala, Matti, Kivinummi, Kati, Tammela, Teuvo L., Nykter, Matti, Isaacs, William B., Lilja, Hans G., Bova, G. Steven, Visakorpi, Tapio

“…Background A significant subset of prostate cancer (PC) patients with a castration-resistant form of the disease (CRPC) show primary resistance to androgen…”
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MSH2 Loss in Primary Prostate Cancer by Guedes, Liana B, Antonarakis, Emmanuel S, Schweizer, Michael T, Mirkheshti, Nooshin, Almutairi, Fawaz, Park, Jong Chul, Glavaris, Stephanie, Hicks, Jessica, Eisenberger, Mario A, De Marzo, Angelo M, Epstein, Jonathan I, Isaacs, William B, Eshleman, James R, Pritchard, Colin C, Lotan, Tamara L

“…Inactivation of mismatch repair (MMR) genes may predict sensitivity to immunotherapy in metastatic prostate cancers. We studied primary prostate tumors with…”
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What Do Myeloma, Breast Cancer, and Prostate Cancer Have in Common? by Isaacs, William B

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The evolutionary history of lethal metastatic prostate cancer by Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B., Tubio, Jose M. C., Papaemmanuil, Elli, Brewer, Daniel S., Kallio, Heini M. L., Högnäs, Gunilla, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O'Meara, Sarah, Dawson, Kevin J., Isaacs, William, Emmert-Buck, Michael R., Nykter, Matti, Foster, Christopher, Kote-Jarai, Zsofia, Easton, Douglas, Whitaker, Hayley C., Neal, David E., Cooper, Colin S., Eeles, Rosalind A., Visakorpi, Tapio, Campbell, Peter J., McDermott, Ultan, Wedge, David C., Bova, G. Steven

“…The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees…”
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Prostate Cancer Predisposition by Bhanji, Yasin, Isaacs, William B., Xu, Jianfeng, Cooney, Kathleen A.

“…The identification and characterization of alterations in prostate cancer (PCa)–predisposing genes can help to inform screening strategies in undiagnosed men…”
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Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019 by Giri, Veda N, Knudsen, Karen E, Kelly, William K, Cheng, Heather H, Cooney, Kathleen A, Cookson, Michael S, Dahut, William, Weissman, Scott, Soule, Howard R, Petrylak, Daniel P, Dicker, Adam P, AlDubayan, Saud H, Toland, Amanda E, Pritchard, Colin C, Pettaway, Curtis A, Daly, Mary B, Mohler, James L, Parsons, J Kellogg, Carroll, Peter R, Pilarski, Robert, Blanco, Amie, Woodson, Ashley, Rahm, Alanna, Taplin, Mary-Ellen, Polascik, Thomas J, Helfand, Brian T, Hyatt, Colette, Morgans, Alicia K, Feng, Felix, Mullane, Michael, Powers, Jacqueline, Concepcion, Raoul, Lin, Daniel W, Wender, Richard, Mark, James Ryan, Costello, Anthony, Burnett, Arthur L, Sartor, Oliver, Isaacs, William B, Xu, Jianfeng, Weitzel, Jeffrey, Andriole, Gerald L, Beltran, Himisha, Briganti, Alberto, Byrne, Lindsey, Calvaresi, Anne, Chandrasekar, Thenappan, Chen, David Y T, Den, Robert B, Dobi, Albert, Crawford, E David, Eastham, James, Eggener, Scott, Freedman, Matthew L, Garnick, Marc, Gomella, Patrick T, Handley, Nathan, Hurwitz, Mark D, Izes, Joseph, Karnes, R Jeffrey, Lallas, Costas, Languino, Lucia, Loeb, Stacy, Lopez, Ana Maria, Loughlin, Kevin R, Lu-Yao, Grace, Malkowicz, S Bruce, Mann, Mark, Mille, Patrick, Miner, Martin M, Morgan, Todd, Moreno, Jose, Mucci, Lorelei, Myers, Ronald E, Nielsen, Sarah M, O'Neil, Brock, Pinover, Wayne, Pinto, Peter, Poage, Wendy, Raj, Ganesh V, Rebbeck, Timothy R, Ryan, Charles, Sandler, Howard, Schiewer, Matthew, Scott, E Michael D, Szymaniak, Brittany, Tester, William, Trabulsi, Edouard J, Vapiwala, Neha, Yu, Evan Y, Zeigler-Johnson, Charnita, Gomella, Leonard G

“…Germline testing (GT) is a central feature of prostate cancer (PCA) treatment, management, and hereditary cancer assessment. Critical needs include optimized…”
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PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients by LOTAN, Tamara L, GUREL, Bora, HAN, Misop, NETTO, George J, ISAACS, William B, DE MARZO, Angelo M, SUTCLIFFE, Siobhan, ESOPI, David, WENNUAN LIU, JIANFENG XU, HICKS, Jessica L, PARK, Ben H, HUMPHREYS, Elizabeth, PARTIN, Alan W

“…Analytically validated assays to interrogate biomarker status in clinical samples are crucial for personalized medicine. PTEN is a tumor suppressor commonly…”
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