Search Results - "IRVING, TOM"

Towards understanding the epidemiology of Neisseria meningitidis in the African meningitis belt: a multi-disciplinary overview by Agier, Lydiane, Martiny, Nadège, Thiongane, Oumy, Mueller, Judith E, Paireau, Juliette, Watkins, Eleanor R, Irving, Tom J, Koutangni, Thibaut, Broutin, Hélène

“…Highlights • A better understanding of the determinants of bacterial meningitis dynamics is crucial. • Improved surveillance and the implementation of…”
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Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy by LASSCHE, Saskia, STIENEN, Ger J. M, IRVING, Tom C, DER MAAREL, Silvere M. Van, VOERMANS, Nicol C, PADBERG, George W, GRANZIER, Henk, ENGELEN, Baziel G. M. Van, OTTENHEIJM, Coen A. C

“…To investigate whether sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy (FSHD). Sarcomeric function was…”
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X-ray Interference Studies of Crossbridge Action in Muscle Contraction: Evidence from Quick Releases by Huxley, Hugh, Reconditi, Massimo, Stewart, Alex, Irving, Tom

“…We have used a high-resolution small angle X-ray scattering system, together with a high-performance CCD camera, on the BioCAT beamline at the APS synchrotron…”
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X-ray Interference Studies of Crossbridge Action in Muscle Contraction: Evidence from Muscles During Steady Shortening by Huxley, Hugh, Reconditi, Massimo, Stewart, Alex, Irving, Tom

“…During normal muscle shortening, the myosin heads must undergo many cycles of interaction with the actin filaments sliding past them. It is important to…”
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The myosin motor in muscle generates a smaller and slower working stroke at higher load by Lucii, Leonardo, Reconditi, Massimo, Boesecke, Peter, Irving, Malcolm, Lombardi, Vincenzo, Stewart, Alex, Narayanan, Theyencheri, Irving, Tom, Piazzesi, Gabriella, Sun, Yin-Biao, Linari, Marco, Fischetti, Robert F

“…Muscle contraction is driven by the motor protein myosin II, which binds transiently to an actin filament, generates a unitary filament displacement or…”
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Crystal Structure of the Actin Binding Domain of the Cyclase-Associated Protein by Dodatko, Tetyana, Fedorov, Alexander A, Grynberg, Marcin, Patskovsky, Yury, Rozwarski, Denise A, Jaroszewski, Lukasz, Aronoff-Spencer, Eliah, Kondraskina, Elena, Irving, Tom, Godzik, Adam, Almo, Steven C

“…Cyclase-associated protein (CAP or Srv2p) is a modular actin monomer binding protein that directly regulates filament dynamics and has been implicated in a…”
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X-ray diffraction studies of the contractile mechanism in single muscle fibres by Holmes, K. C., Trentham, D. R., Simmons, R., Lombardi, Vincenzo, Piazzesi, Gabriella, Reconditi, Massimo, Linari, Marco, Lucii, Leonardo, Stewart, Alex, Sun, Yin-Biao, Boesecke, Peter, Narayanan, Theyencheri, Irving, Tom, Irving, Malcolm

“…The molecular mechanism of muscle contraction was investigated in intact muscle fibres by X–ray diffraction. Changes in the intensities of the axial X–ray…”
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Epidemiological impact and cost-effectiveness of universal vaccination with Bexsero® to reduce meningococcal group B disease in Germany by Christensen, Hannah, Irving, Tom, Koch, Judith, Trotter, Caroline L, Ultsch, Bernhard, Weidemann, Felix, Wichmann, Ole, Hellenbrand, Wiebke

“…Highlights • We modelled the potential impact of vaccination against MenB disease in Germany. • Without herd effects, predicted MenB cases averted through…”
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Introduction to Intellectual Property: A U.S. Perspective by Murphy, Amanda, Stramiello, Michael, Lewis, Stacy, Irving, Tom

“…This review introduces patents and trade secrets, the two mechanisms that U.S. law provides inventors to protect their inventions. These mechanisms are…”
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Time-resolved SAXS using continuous-flow microfluidic mixers by Bilsel, Osman, Chakravarthy, Srinivas, Kathuria, Sagar, Inguva, Venkatesh, Perot, J. Blair, Irving, Tom

“…Abstract only…”
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Impact of America Invents Act on Biotech Intellectual Property by Murphy, Amanda, Stramiello, Michael, Stroud, Jonathan, Lewis, Stacy, Irving, Tom

“…This review introduces the America Invents Act (AIA), a comprehensive reform of U.S. law on patentability and patent enforceability that Congress enacted in…”
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Epidemiological impact and cost-effectiveness of universal vaccination with Bexsero registered to reduce meningococcal group B disease in Germany by Christensen, Hannah, Irving, Tom, Koch, Judith, Trotter, Caroline L, Ultsch, Bernhard, Weidemann, Felix, Wichmann, Ole, Hellenbrand, Wiebke

“…Bexsero, a new vaccine against serogroup B meningococcal disease (MenB), was licensed in Europe in January 2013. In Germany, Bexsero is recommended for persons…”
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Introduction to Intellectual Property: A U.S. Perspective: Figure 1 by Murphy, Amanda, Stramiello, Michael, Lewis, Stacy, Irving, Tom

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The Intensity Of The 2.7nm Reflection As A Constraint For Models Of Myosin Docking To Actin by Reconditi, Massimo, Irving, Tom C.

“…Previous workers have proposed high resolution models for the docking of the myosin heads on actin on the basis of combined crystallographic and electron…”
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Cardiac Thin Filament Structural Modulation by Sarcomere Length by Aitmou, Younss, Hsu, Karen H., Kumar, Mohit, Szczesna-Cordary, Danuta, Greaser, Marion L., Irving, Tom C., deTombe, Pieter P.

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New X-ray Data about Myosin-binding Protein C in Frog Muscle by Huxley, Hugh, Reconditi, Massimo, Irving, Tom

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X-Ray Diffraction Study of the Effect of Temperature on the Structure of Mammalian Muscle at Rest and During Isometric Contraction by Caremani, Marco, Reconditi, Massimo, Brunello, Elisabetta, Linari, Marco, Gore, David, Irving, Tom, Piazzesi, Gabriella, Irving, Malcom, Lombardi, Vincenzo

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Structural insights into early folding events using continuous-flow time-resolved SAXS by Kathuria, Sagar V., Guo, Liang, Graceffa, Rita, Barrea, Raul, Nobrega, R. Paul, Matthews, C. Robert, Irving, Tom, Bilsel, Osman

“…Small-angle x-ray scattering (SAXS) is a powerful method for obtaining quantitative structural information on the size and shape of proteins, and it is…”
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Corrigendum to “X-ray Interference Studies of Crossbridge Action in Muscle Contraction: Evidence from Muscles During Steady Shortening” [J. Mol. Biol. 363 (2006), 762–772] by Huxley, Hugh, Reconditi, Massimo, Stewart, Alex, Irving, Tom

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Using hair to screen for breast cancer by James, Veronica, Kearsley, John, Irving, Tom, Amemiya, Yoshiyuki, Cookson, David

“…We have studied hair using fibre X-ray diffraction studies with synchrotron radiation and find that hair from breast-cancer patients has a different…”
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