Search Results - "IRVINE, J."

Order–disorder and ionic conductivity in calcium nitride-hydride by Irvine, G. J., Smith, Ronald I., Jones, M. O., Irvine, J. T. S.

“…Recently nitrogen-hydrogen compounds have successfully been applied as co-catalysts for mild conditions ammonia synthesis. Ca 2 NH was shown to act as a H 2…”
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Synthetic Nanoparticles for Vaccines and Immunotherapy by Irvine, Darrell J, Hanson, Melissa C, Rakhra, Kavya, Tokatlian, Talar

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Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity by Zhang, Yuan, Li, Na, Suh, Heikyung, Irvine, Darrell J.

“…Immunostimulatory agents such as agonistic anti-CD137 and interleukin (IL)−2 generate effective anti-tumor immunity but also elicit serious toxicities,…”
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Roles for Innate Immunity in Combination Immunotherapies by Moynihan, Kelly D, Irvine, Darrell J

“…Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with many feed-forward and regulatory…”
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Engineering Nano- and Microparticles to Tune Immunity by Moon, James J., Huang, Bonnie, Irvine, Darrell J.

“…The immune system can be a cure or cause of disease, fulfilling a protective role in attacking cancer or pathogenic microbes but also causing tissue…”
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Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo by Kato, Yu, Abbott, Robert K., Freeman, Brian L., Haupt, Sonya, Groschel, Bettina, Silva, Murillo, Menis, Sergey, Irvine, Darrell J., Schief, William R., Crotty, Shane

“…How antigen valency affects B cells in vivo during immune responses is not well understood. Here, using HIV immunogens with defined valencies ranging from 1 to…”
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Structure-based programming of lymph-node targeting in molecular vaccines by Liu, Haipeng, Moynihan, Kelly D., Zheng, Yiran, Szeto, Gregory L., Li, Adrienne V., Huang, Bonnie, Van Egeren, Debra S., Park, Clara, Irvine, Darrell J.

“…An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by…”
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Role of nanoscale antigen organization on B-cell activation probed using DNA origami by Veneziano, Rémi, Moyer, Tyson J., Stone, Matthew B., Wamhoff, Eike-Christian, Read, Benjamin J., Mukherjee, Sayak, Shepherd, Tyson R., Das, Jayajit, Schief, William R., Irvine, Darrell J., Bathe, Mark

“…Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like nanoparticles to enhance B-cell activation. However, the effects of…”
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T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity by Schmid, Daniela, Park, Chun Gwon, Hartl, Christina A., Subedi, Nikita, Cartwright, Adam N., Puerto, Regina Bou, Zheng, Yiran, Maiarana, James, Freeman, Gordon J., Wucherpfennig, Kai W., Irvine, Darrell J., Goldberg, Michael S.

“…Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because…”
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Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance by Cirelli, Kimberly M., Carnathan, Diane G., Nogal, Bartek, Martin, Jacob T., Rodriguez, Oscar L., Upadhyay, Amit A., Enemuo, Chiamaka A., Gebru, Etse H., Choe, Yury, Viviano, Federico, Nakao, Catherine, Pauthner, Matthias G., Reiss, Samantha, Cottrell, Christopher A., Smith, Melissa L., Bastidas, Raiza, Gibson, William, Wolabaugh, Amber N., Melo, Mariane B., Cossette, Benjamin, Kumar, Venkatesh, Patel, Nirav B., Tokatlian, Talar, Menis, Sergey, Kulp, Daniel W., Burton, Dennis R., Murrell, Ben, Schief, William R., Bosinger, Steven E., Ward, Andrew B., Watson, Corey T., Silvestri, Guido, Irvine, Darrell J., Crotty, Shane

“…Conventional immunization strategies will likely be insufficient for the development of a broadly neutralizing antibody (bnAb) vaccine for HIV or other…”
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Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials by Stephan, Matthias T., Irvine, Darrell J.

“…[Display omitted] ► In this review, we will first summarize key methodologies used to manipulate the surface of living mammalian cells with synthetic material…”
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Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy by Kwong, Brandon, Liu, Haipeng, Irvine, Darrell J

“…Abstract Immunostimulatory therapies that activate immune response pathways are of great interest for overcoming the immunosuppression present in advanced…”
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Wetting and interactions of Ag–Cu–Ti and Ag–Cu–Ni alloys with ceramic and steel substrates for use as sealing materials in a DCFC stack by Triantafyllou, G, Irvine, J. T. S

“…Ag and Ag-based pseudo-alloys were evaluated in terms of application as metal brazes for the use in a hybrid direct carbon fuel cell stack. This paper reports…”
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An overview of the Earth system science of solar geoengineering by Irvine, Peter J., Kravitz, Ben, Lawrence, Mark G., Muri, Helene

“…Solar geoengineering has been proposed as a means to cool the Earth by increasing the reflection of sunlight back to space, for example, by injecting…”
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Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants by Hanson, Melissa C, Crespo, Monica P, Abraham, Wuhbet, Moynihan, Kelly D, Szeto, Gregory L, Chen, Stephanie H, Melo, Mariane B, Mueller, Stefanie, Irvine, Darrell J

“…Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected…”
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Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers by Tokatlian, Talar, Read, Benjamin J, Jones, Christopher A, Kulp, Daniel W, Menis, Sergey, Chang, Jason Y H, Steichen, Jon M, Kumari, Sudha, Allen, Joel D, Dane, Eric L, Liguori, Alessia, Sangesland, Maya, Lingwood, Daniel, Crispin, Max, Schief, William R, Irvine, Darrell J

“…In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such…”
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High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry by Yang, Yu-Sang Sabrina, Atukorale, Prabhani U., Moynihan, Kelly D., Bekdemir, Ahmet, Rakhra, Kavya, Tang, Li, Stellacci, Francesco, Irvine, Darrell J.

“…Inorganic nanoparticles (NPs) are studied as drug carriers, radiosensitizers and imaging agents, and characterizing nanoparticle biodistribution is essential…”
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Halving warming with stratospheric aerosol geoengineering moderates policy-relevant climate hazards by Irvine, Peter J, Keith, David W

“…Stratospheric aerosol geoengineering is a proposal to artificially thicken the layer of reflective aerosols in the stratosphere and it is hoped that this may…”
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In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles by Su, Xingfang, Fricke, Jennifer, Kavanagh, Daniel G, Irvine, Darrell J

“…Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo…”
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HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies by Steichen, Jon M., Kulp, Daniel W., Tokatlian, Talar, Escolano, Amelia, Dosenovic, Pia, Stanfield, Robyn L., McCoy, Laura E., Ozorowski, Gabriel, Hu, Xiaozhen, Kalyuzhniy, Oleksandr, Briney, Bryan, Schiffner, Torben, Garces, Fernando, Freund, Natalia T., Gitlin, Alexander D., Menis, Sergey, Georgeson, Erik, Kubitz, Michael, Adachi, Yumiko, Jones, Meaghan, Mutafyan, Andrew A., Yun, Dong Soo, Mayer, Christian T., Ward, Andrew B., Burton, Dennis R., Wilson, Ian A., Irvine, Darrell J., Nussenzweig, Michel C., Schief, William R.

“…Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope (Env) trimer are the most common bnAbs induced during infection, making…”
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