Search Results - "IRVINE, G. Brent"

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases by Irvine, G Brent, El-Agnaf, Omar M, Shankar, Ganesh M, Walsh, Dominic M

“…Developing effective treatments for neurodegenerative diseases is one of the greatest medical challenges of the 21st century. Although many of these clinical…”
Get full text

novel reciprocal and biphasic relationship between membrane cholesterol and β-secretase activity in SH-SY5Y cells and in human platelets by Liu, Wei Wei, Todd, Stephen, Coulson, David T.R, Brent Irvine, G, Peter Passmore, A, McGuinness, Bernadette, McConville, Maeve, Craig, David, Johnston, Janet A

“…Research into the cause of Alzheimer's disease (AD) has identified strong connections to cholesterol. Cholesterol and cholesterol esters can modulate amyloid…”
Get full text

ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain by Beyer, Nancy, Coulson, David Tr, Heggarty, Shirley, Ravid, Rivka, Irvine, G Brent, Hellemans, Jan, Johnston, Janet A

“…ZnT3 is a membrane Zn(2+ )transporter that is responsible for concentrating Zn(2+ )into neuronal presynaptic vesicles. Zn(2+ )homeostasis in the brain is…”
Get full text

Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue by Coulson, David T R, Brockbank, Simon, Quinn, Joseph G, Murphy, Suzanne, Ravid, Rivka, Irvine, G Brent, Johnston, Janet A

“…Studies of gene expression in post mortem human brain can contribute to understanding of the pathophysiology of neurodegenerative diseases, including…”
Get full text

Familial genes in sporadic disease: Common variants of α- synuclein gene associate with Parkinson's disease by Ross, Owen A., Gosal, David, Stone, Jeremy T., Lincoln, Sarah J., Heckman, Michael G., Irvine, G. Brent, Johnston, Janet A., Gibson, J. Mark, Farrer, Matthew J., Lynch, Timothy

“…Genetic variation of the α- synuclein gene ( SNCA) is known to cause familial parkinsonism, however the role of SNCA variants in sporadic Parkinson's disease…”
Get full text

Zinc transporter mRNA levels in Alzheimer's disease postmortem brain by Beyer, Nancy, Coulson, David T R, Heggarty, Shirley, Ravid, Rivka, Hellemans, Jan, Irvine, G Brent, Johnston, Janet A

“…Zinc (Zn2+) is concentrated into pre-synaptic vesicles and co-released with neurotransmitter at some synapses. Zn2+ can accelerate assembly of the amyloid-β…”
Get more information

α-Synuclein mRNA and soluble α-synuclein protein levels in post-mortem brain from patients with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease by Quinn, Joseph G, Coulson, David T.R, Brockbank, Simon, Beyer, Nancy, Ravid, Rivka, Hellemans, Jan, Irvine, G. Brent, Johnston, Janet A

“…Abstract α-Synuclein is a neuronal protein implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Whilst increased…”
Get full text

BACE1 mRNA expression in Alzheimer's disease postmortem brain tissue by Coulson, David T R, Beyer, Nancy, Quinn, Joe G, Brockbank, Simon, Hellemans, Jan, Irvine, G Brent, Ravid, Rivka, Johnston, Janet A

“…β-site AβPP cleaving enzyme 1 (BACE1) catalyses the rate-limiting step for production of amyloid-β (Aβ) peptides, involved in the pathological cascade…”
Get more information

Inhibitors of α-synuclein oligomerization and toxicity : a future therapeutic strategy for Parkinson's disease and related disorders by AMER, Dena A. M, IRVINE, G. Brent, EL-AGNAF, Omar M. A

“…An abundance of genetic, histopathological, and biochemical evidence has implicated the neuronal protein, alpha-synuclein (alpha-syn) as a key player in the…”
Get full text

Identification of the region of non‐Aβ component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity by Bodles, Angela M., Guthrie, David J. S., Greer, Brett, Irvine, G. Brent

“…The non‐beta‐amyloid (Aβ) component of Alzheimer's disease amyloid (NAC) and its precursor α‐synuclein have been linked to amyloidogenesis in several…”
Get full text

IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B by Pathmanathan, Sevvel, Elliott, Sarah F, McSwiggen, Sara, Greer, Brett, Harriott, Pat, Irvine, G. Brent, Timson, David J

“…IQGAPs are cytoskeletal scaffolding proteins which link signalling pathways to the reorganisation of actin and microtubules. Human IQGAP1 has four IQ motifs…”
Get full text

Inhibition of fibril formation and toxicity of a fragment of α-synuclein by an N-methylated peptide analogue by Bodles, Angela M., El-Agnaf, Omar M.A., Greer, Brett, Guthrie, David J.S., Irvine, G.Brent

“…α-Synuclein has been linked to amyloidogenesis in Parkinson's disease and other neurodegenerative disorders. We have previously shown that a peptide comprising…”
Get full text

Variation in RTN3 and PPIL2 Genes Does not Influence Platelet Membrane β-Secretase Activity or Susceptibility to Alzheimer’s Disease in the Northern Irish Population by Carson, Robyn, McKnight, Amy Jayne, Todd, Stephen, Liu, Wei Wei, Heggarty, Shirley, Craig, David, McGuinness, Bernadette, Irvine, G. Brent, Passmore, A. Peter, Johnston, Janet A.

“…β-site amyloid precursor protein cleaving enzyme (BACE1) is the rate-limiting enzyme for production of beta-amyloid peptides (Aβ), which are proposed to drive…”
Get full text

Clinical traits of LRRK2-associated Parkinson's disease in Ireland: A link between familial and idiopathic PD by Gosal, David, Ross, Owen A., Wiley, Joe, Irvine, G. Brent, Johnston, Janet A., Toft, Mathias, Mata, Ignacio F., Kachergus, Jennifer, Hulihan, Mary, Taylor, Julie P., Lincoln, Sarah J., Farrer, Matthew J., Lynch, Timothy, Mark Gibson, J.

“…The role of genetics in parkinsonism has been confirmed over the last decade with the identification of genetic variation in seven genes, which are causative…”
Get full text

Amino acid analysis. Precolumn derivatization methods by Irvine, G Brent, Davidson, Ian

Get more information

Alpha-synuclein aggregation by Bodles, Angela M, Irvine, G Brent

“…Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other…”
Get more information

Determination of molecular size by size-exclusion chromatography (gel filtration) by Irvine, G B

“…Size-exclusion or gel filtration chromatography is one of the most popular methods for determining the sizes of proteins. Proteins in solution, or other…”
Get more information

High-performance size-exclusion chromatography of peptides by Irvine, G.Brent

“…Gel filtration on soft gels has been employed for over 40 years for the separation, desalting and molecular weight estimation of peptides and proteins…”
Get full text

Serum neurone-specific enolase levels in patients with neuroendocrine and carcinoid tumours by Cunningham, R T, Johnston, C F, Irvine, G B, Buchanan, K D

“…We have examined concentrations of neurone-specific enolase (NSE) in sera from 18 patients with various neuroendocrine tumours, 26 patients with carcinoid…”
Get more information

Visual detection of peptidase activity using fluorogenic substrates in a microtiter plate assay by Irvine, G B, Ennis, M, Williams, C H

“…A simple, inexpensive, and sensitive assay for peptidase activity has been devised. The assay was performed in a microtiter plate and was based on fluorogenic…”
Get more information