Search Results - "IRISH, Jonathan"

Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study by Nair, Navya, Camacho-Vanegas, Olga, Rykunov, Dmitry, Dashkoff, Matthew, Camacho, Sandra Catalina, Schumacher, Cassie A, Irish, Jonathan C, Harkins, Timothy T, Freeman, Elijah, Garcia, Isaac, Pereira, Elena, Kendall, Sviatoslav, Belfer, Rachel, Kalir, Tamara, Sebra, Robert, Reva, Boris, Dottino, Peter, Martignetti, John A

“…Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect…”
Get full text

3D Rapid Prototyping for Otolaryngology-Head and Neck Surgery: Applications in Image-Guidance, Surgical Simulation and Patient-Specific Modeling by Chan, Harley H L, Siewerdsen, Jeffrey H, Vescan, Allan, Daly, Michael J, Prisman, Eitan, Irish, Jonathan C

“…The aim of this study was to demonstrate the role of advanced fabrication technology across a broad spectrum of head and neck surgical procedures, including…”
Get full text

Two New Neutrophil Subsets Define a Discriminating Sepsis Signature by Meghraoui-Kheddar, Aïda, Chousterman, Benjamin G, Guillou, Noëlline, Barone, Sierra M, Granjeaud, Samuel, Vallet, Helene, Corneau, Aurélien, Guessous, Karim, de Roquetaillade, Charles, Boissonnas, Alexandre, Irish, Jonathan M, Combadière, Christophe

“…Sepsis is the leading cause of death in adult ICUs. At present, sepsis diagnosis relies on nonspecific clinical features. It could transform clinical care to…”
Get full text

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy by Johnson, Douglas B., Estrada, Monica V., Salgado, Roberto, Sanchez, Violeta, Doxie, Deon B., Opalenik, Susan R., Vilgelm, Anna E., Feld, Emily, Johnson, Adam S., Greenplate, Allison R., Sanders, Melinda E., Lovly, Christine M., Frederick, Dennie T., Kelley, Mark C., Richmond, Ann, Irish, Jonathan M., Shyr, Yu, Sullivan, Ryan J., Puzanov, Igor, Sosman, Jeffrey A., Balko, Justin M.

“…Anti-PD-1 therapy yields objective clinical responses in 30–40% of advanced melanoma patients. Since most patients do not respond, predictive biomarkers to…”
Get full text

Characterizing cell subsets using marker enrichment modeling by Diggins, Kirsten E, Greenplate, Allison R, Leelatian, Nalin, Wogsland, Cara E, Irish, Jonathan M

“…Marker enrichment modeling (MEM) provides an objective metric for characterizing cell populations from high-content single-cell analysis. The MEM score…”
Get full text

Methods for discovery and characterization of cell subsets in high dimensional mass cytometry data by Diggins, Kirsten E., Ferrell, P. Brent, Irish, Jonathan M.

“…[Display omitted] •Bioinformatics strategy for analysis of high-dimensional single cell data.•Unsupervised approaches reveal and characterize cells with…”
Get full text

A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics by Cui, Liyang, Lin, Qiaoya, Jin, Cheng S, Jiang, Wenlei, Huang, Huang, Ding, Lili, Muhanna, Nidal, Irish, Jonathan C, Wang, Fan, Chen, Juan, Zheng, Gang

“…PEGylation (PEG) is the most commonly adopted strategy to prolong nanoparticles’ vascular circulation by mitigating the reticuloendothelial system uptake…”
Get full text

The 2018 American Head and Neck Society Presidential Address-Reflections by Irish, Jonathan C

“…Jonathan C. Irish, President of the American Head and Neck Society (AHNS) for 2017 to 2018, in his Presidential Address highlights the challenges and…”
Get more information

Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response by Levine, Lauren S., Hiam-Galvez, Kamir J., Marquez, Diana M., Tenvooren, Iliana, Madden, Matthew Z., Contreras, Diana C., Dahunsi, Debolanle O., Irish, Jonathan M., Oluwole, Olalekan O., Rathmell, Jeffrey C., Spitzer, Matthew H.

“…Memory T cells are thought to rely on oxidative phosphorylation and short-lived effector T cells on glycolysis. Here, we investigated how T cells arrive at…”
Get full text

Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma by Green, Michael R., Gentles, Andrew J., Nair, Ramesh V., Irish, Jonathan M., Kihira, Shingo, Liu, Chih Long, Kela, Itai, Hopmans, Erik S., Myklebust, June H., Ji, Hanlee, Plevritis, Sylvia K., Levy, Ronald, Alizadeh, Ash A.

“…Follicular lymphoma (FL) is currently incurable using conventional chemotherapy or immunotherapy regimes, compelling new strategies. Advances in…”
Get full text

Picturing Polarized Myeloid Phagocytes and Regulatory Cells by Mass Cytometry by Roussel, Mikael, Bartkowiak, Todd, Irish, Jonathan M

“…The immune monocyte/phagocyte system (MPS) includes numerous cell subsets of the myeloid lineage including monocyte, macrophage, and dendritic cell (DC)…”
Get more information

Learning cell identity in immunology, neuroscience, and cancer by Medina, Stephanie, Ihrie, Rebecca A., Irish, Jonathan M.

“…Suspension and imaging cytometry techniques that simultaneously measure hundreds of cellular features are powering a new era of cell biology and transforming…”
Get full text

Localization of Pulmonary Nodules Using Navigation Bronchoscope and a Near-Infrared Fluorescence Thoracoscope by Anayama, Takashi, MD, PhD, Qiu, Jimmy, MS, Chan, Harley, PhD, Nakajima, Takahiro, MD, PhD, Weersink, Robert, PhD, Daly, Michael, MS, McConnell, Judy, BS, Waddell, Thomas, MD, PhD, Keshavjee, Shaf, MD, MS, Jaffray, David, PhD, Irish, Jonathan C., MD, MS, Hirohashi, Kentaro, MD, Wada, Hironobu, MD, PhD, Orihashi, Kazumasa, MD, PhD, Yasufuku, Kazuhiro, MD, PhD

“…Background Video-assisted thoracoscopic wedge resection of multiple small, non-visible, and nonpalpable pulmonary nodules is a clinical challenge. We propose…”
Get full text

Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas by Huang, Shao Hui, Xu, Wei, Waldron, John, Siu, Lillian, Shen, Xiaowei, Tong, Li, Ringash, Jolie, Bayley, Andrew, Kim, John, Hope, Andrew, Cho, John, Giuliani, Meredith, Hansen, Aaron, Irish, Jonathan, Gilbert, Ralph, Gullane, Patrick, Perez-Ordonez, Bayardo, Weinreb, Ilan, Liu, Fei-Fei, O'Sullivan, Brian

“…To refine stage and prognostic group for human papillomavirus (HPV) -related nonmetastatic (M0) oropharyngeal cancer (OPC). All patients with nonmetastatic…”
Get full text

Impact of cancer surgery slowdowns on patient survival during the COVID-19 pandemic: a microsimulation modelling study by Parmar, Ambica, Eskander, Antoine, Sander, Beate, Naimark, David, Irish, Jonathan C, Chan, Kelvin K W

“…With the declaration of the global pandemic, surgical slowdowns were instituted to conserve health care resources for anticipated surges in patients with…”
Get full text

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation by Green, Michael R., Kihira, Shingo, Liu, Chih Long, Nair, Ramesh V., Salari, Raheleh, Gentles, Andrew J., Irish, Jonathan, Stehr, Henning, Vicente-Dueñas, Carolina, Romero-Camarero, Isabel, Sanchez-Garcia, Isidro, Plevritis, Sylvia K., Arber, Daniel A., Batzoglou, Serafim, Levy, Ronald, Alizadeh, Ash A.

“…Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical course typified by multiple relapses after therapy. These tumors are…”
Get full text

An integrated augmented reality surgical navigation platform using multi-modality imaging for guidance by Chan, Harley H L, Haerle, Stephan K, Daly, Michael J, Zheng, Jinzi, Philp, Lauren, Ferrari, Marco, Douglas, Catriona M, Irish, Jonathan C

“…An integrated augmented reality (AR) surgical navigation system that potentially improves intra-operative visualization of concealed anatomical structures…”
Get full text

Web-based analysis and publication of flow cytometry experiments by Kotecha, Nikesh, Krutzik, Peter O, Irish, Jonathan M

“…Cytobank is a Web-based application for storage, analysis, and sharing of flow cytometry experiments. Researchers use a Web browser to log in and use a wide…”
Get more information

Deintensification Candidate Subgroups in Human Papillomavirus–Related Oropharyngeal Cancer According to Minimal Risk of Distant Metastasis by O'Sullivan, Brian, Huang, Shao Hui, Siu, Lillian L, Waldron, John, Zhao, Helen, Perez-Ordonez, Bayardo, Weinreb, Ilan, Kim, John, Ringash, Jolie, Bayley, Andrew, Dawson, Laura A, Hope, Andrew, Cho, John, Irish, Jonathan, Gilbert, Ralph, Gullane, Patrick, Hui, Angela, Liu, Fei-Fei, Chen, Eric, Xu, Wei

“…To define human papillomavirus (HPV) -positive oropharyngeal cancers (OPC) suitable for treatment deintensification according to low risk of distant metastasis…”
Get full text

Mapping normal and cancer cell signalling networks: towards single-cell proteomics by Nolan, Garry P, Irish, Jonathan M, Kotecha, Nikesh

“…Oncogenesis and tumour progression are supported by alterations in cell signalling. Using flow cytometry, it is now possible to track and analyse signalling…”
Get full text