Search Results - "IRIMIE, ALEXANDRU"

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer by Braicu, Cornelia, Buse, Mihail, Busuioc, Constantin, Drula, Rares, Gulei, Diana, Raduly, Lajos, Rusu, Alexandru, Irimie, Alexandru, Atanasov, Atanas G., Slaby, Ondrej, Ionescu, Calin, Berindan-Neagoe, Ioana

“…The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of…”
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The Role of Nrf2 Activity in Cancer Development and Progression by Zimta, Alina-Andreea, Cenariu, Diana, Irimie, Alexandru, Magdo, Lorand, Nabavi, Seyed Mohammad, Atanasov, Atanas G, Berindan-Neagoe, Ioana

“…Nrf2 is a transcription factor that stimulates the expression of genes which have antioxidant response element-like sequences in their promoter. Nrf2 is a…”
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The relationship between the structure and biological actions of green tea catechins by Braicu, Cornelia, Ladomery, Michael R., Chedea, Veronica S., Irimie, Alexandru, Berindan-Neagoe, Ioana

“…•Catechins have effects based on preclinical and clinical trials studies.•Catechins exhibit both pro- and antioxidant activities.•Catechins multiple uses in…”
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The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases by Balacescu, Ovidiu, Sur, Daniel, Cainap, Calin, Visan, Simona, Cruceriu, Daniel, Manzat-Saplacan, Roberta, Muresan, Mihai-Stefan, Balacescu, Loredana, Lisencu, Cosmin, Irimie, Alexandru

“…Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies with a high incidence and mortality rate. An essential challenge in colorectal…”
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Nanoscale delivery systems for microRNAs in cancer therapy by Boca, Sanda, Gulei, Diana, Zimta, Alina-Andreea, Onaciu, Anca, Magdo, Lorand, Tigu, Adrian Bogdan, Ionescu, Calin, Irimie, Alexandru, Buiga, Rares, Berindan-Neagoe, Ioana

“…Concomitant with advances in research regarding the role of miRNAs in sustaining carcinogenesis, major concerns about their delivery options for anticancer…”
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Apoptosis in cancer: key molecular signaling pathways and therapy targets by Burz, Claudia, Berindan-Neagoe, Ioana, Balacescu, Ovidiu, Irimie, Alexandru

“…Apoptosis is a physiological process vital for embryologic development and the maintenance of homeostasis in multicellular organisms, but it is also involved…”
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Exosomes in Colorectal Cancer: From Physiology to Clinical Applications by Titu, Stefan, Gata, Vlad Alexandru, Decea, Roxana Maria, Mocan, Teodora, Dina, Constantin, Irimie, Alexandru, Lisencu, Cosmin Ioan

“…Exosomes are nanosized vesicles that have been found to be involved in many diseases. Exosomes can mediate communication between cells in a variety of ways…”
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The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis by Ling, Hui, Pickard, Karen, Ivan, Cristina, Isella, Claudio, Ikuo, Mariko, Mitter, Richard, Spizzo, Riccardo, Bullock, Marc, Braicu, Cornelia, Pileczki, Valentina, Vincent, Kimberly, Pichler, Martin, Stiegelbauer, Verena, Hoefler, Gerald, Almeida, Maria I, Hsiao, Annie, Zhang, Xinna, Primrose, John, Packham, Graham, Liu, Kevin, Bojja, Krishna, Gafà, Roberta, Xiao, Lianchun, Rossi, Simona, Song, Jian H, Vannini, Ivan, Fanini, Francesca, Kopetz, Scott, Zweidler-McKay, Patrick, Wang, Xuemei, Ionescu, Calin, Irimie, Alexandru, Fabbri, Muller, Lanza, Giovanni, Hamilton, Stanley R, Berindan-Neagoe, Ioana, Medico, Enzo, Mirnezami, Alex, Calin, George A, Nicoloso, Milena S

“…MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC)…”
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p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells by Braicu, Cornelia, Pileczki, Valentina, Irimie, Alexandru, Berindan-Neagoe, Ioana

“…p53 protein is probably the best known tumor suppressor. Earlier reports proved that human breast cancer cells expressing mutant p53 displayed resistance to…”
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Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell Lines-Possible Implications in New Therapeutic Strategies by Budisan, Liviuta, Gulei, Diana, Jurj, Ancuta, Braicu, Cornelia, Zanoaga, Oana, Cojocneanu, Roxana, Pop, Laura, Raduly, Lajos, Barbat, Alexandru, Moldovan, Alin, Moldovan, Cristian, Tigu, Adrian Bogdan, Ionescu, Calin, Atanasov, Atanas G, Irimie, Alexandru, Berindan-Neagoe, Ioana

“…Phytochemicals are natural compounds synthesized as secondary metabolites in plants and represent an important source of molecules with therapeutic…”
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The role of Skp2 and its substrate CDKN1B (p27) in colorectal cancer by Bochis, Ovidiu V, Irimie, Alexandru, Pichler, Martin, Berindan-Neagoe, Ioana

“…Colorectal cancer is one of the most frequent cancers worldwide, having the fourth mortality rate among cancers in both sexes. Numerous studies are…”
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Aberrant miRNAs expressed in HER-2 negative breast cancers patient by Braicu, Cornelia, Raduly, Lajos, Morar-Bolba, Gabriela, Cojocneanu, Roxana, Jurj, Ancuta, Pop, Laura-Ancuta, Pileczki, Valentina, Ciocan, Cristina, Moldovan, Alin, Irimie, Alexandru, Eniu, Alexandru, Achimas-Cadariu, Patriciu, Paradiso, Angelo, Berindan-Neagoe, Ioana

“…Breast cancer is a highly heterogeneous pathology, exhibiting a number of subtypes commonly associated with a poor outcome. Due to their high stability,…”
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Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression by Braicu, Cornelia, Buiga, Rares, Cojocneanu, Roxana, Buse, Mihail, Raduly, Lajos, Pop, Laura Ancuta, Chira, Sergiu, Budisan, Liviuta, Jurj, Ancuta, Ciocan, Cristina, Magdo, Lorand, Irimie, Alexandru, Dobrota, Florentin, Petrut, Bogdan, Berindan-Neagoe, Ioana

“…Bladder cancer (BC) is a common urothelial malignancy, characterized by a high recurrence rate. The biology of bladder cancer is complex and needs to be…”
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Current and New Predictors for Treatment Response in Metastatic Colorectal Cancer. The Role of Circulating miRNAs as Biomarkers by Gherman, Alexandra, Balacescu, Loredana, Gheorghe-Cetean, Sinziana, Vlad, Catalin, Balacescu, Ovidiu, Irimie, Alexandru, Lisencu, Cosmin

“…Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world. More than half of all CRC patients will eventually develop metastases and…”
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Impact of Sarcopenia on Treatment Outcomes and Toxicity in Locally Advanced Rectal Cancer by Curcean, Sebastian, Gherman, Alexandra, Tipcu, Alexandru, Fekete, Zsolt, Muntean, Alina-Simona, Curcean, Andra, Craciun, Rares, Stanciu, Stefan, Irimie, Alexandru

“…: Sarcopenia, a condition characterized by muscle mass loss, is prevalent in up to 68% of rectal cancer patients and has been described as a negative…”
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Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation by Adam-Bonci, Teodora-Irina, Bonci, Eduard-Alexandru, Pârvu, Alina-Elena, Herdean, Andrei-Ioan, Moț, Augustin, Taulescu, Marian, Ungur, Andrei, Pop, Raluca-Maria, Bocșan, Corina, Irimie, Alexandru

“…Asthma oxidative stress disturbances seem to enable supplementary proinflammatory pathways, thus contributing to disease development and severity. The current…”
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Beyond Conventional: The New Horizon of Anti-Angiogenic microRNAs in Non-Small Cell Lung Cancer Therapy by Tirpe, Alexandru, Gulei, Diana, Tirpe, George Razvan, Nutu, Andreea, Irimie, Alexandru, Campomenosi, Paola, Pop, Laura Ancuta, Berindan-Neagoe, Ioana

“…GLOBOCAN 2018 identified lung cancer as the leading oncological pathology in terms of incidence and mortality rates. Angiogenesis is a key adaptive mechanism…”
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Identification of Core Genes Involved in the Progression of Cervical Cancer Using an Integrative mRNA Analysis by Dudea-Simon, Marina, Mihu, Dan, Irimie, Alexandru, Cojocneanu, Roxana, Korban, Schuyler S, Oprean, Radu, Braicu, Cornelia, Berindan-Neagoe, Ioana

“…In spite of being a preventable disease, cervical cancer (CC) remains at high incidence, and it has a significant mortality rate. Although hijacking of the…”
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The relationships between biological activities and structure of flavan-3-ols by Braicu, Cornelia, Pilecki, Valentina, Balacescu, Ovidiu, Irimie, Alexandru, Neagoe, Ioana Berindan

“…Flavan-3-ols are involved in multiple metabolic pathways that induce inhibition of cell proliferation. We studied the structure-activity relationship of gallic…”
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Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present by Achimas-Cadariu, Patriciu, Kubelac, Paul, Irimie, Alexandru, Berindan-Neagoe, Ioana, Rühli, Frank

“…Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and…”
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