Search Results - "IOVANNA, Juan Lucio"

TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma by Adjuto-Saccone, Marjorie, Soubeyran, Philippe, Garcia, Julie, Audebert, Stéphane, Camoin, Luc, Rubis, Marion, Roques, Julie, Binétruy, Bernard, Iovanna, Juan Lucio, Tournaire, Roselyne

“…Endothelial–mesenchymal transition (EndMT) is an important source of cancer-associated fibroblasts (CAFs), which facilitates tumour progression. PDAC is…”
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Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression by Gouirand, Victoire, Gicquel, Tristan, Lien, Evan C, Jaune‐Pons, Emilie, Da Costa, Quentin, Finetti, Pascal, Metay, Elodie, Duluc, Camille, Mayers, Jared R, Audebert, Stephane, Camoin, Luc, Borge, Laurence, Rubis, Marion, Leca, Julie, Nigri, Jeremy, Bertucci, François, Dusetti, Nelson, Iovanna, Juan Lucio, Tomasini, Richard, Bidaut, Ghislain, Guillaumond, Fabienne, Vander Heiden, Matthew G, Vasseur, Sophie

“…Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients and therefore must adapt their metabolism to ensure proliferation. In…”
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Regulation of NUB1 Activity through Non-Proteolytic Mdm2-Mediated Ubiquitination by Bonacci, Thomas, Audebert, Stéphane, Camoin, Luc, Baudelet, Emilie, Iovanna, Juan-Lucio, Soubeyran, Philippe

“…NUB1 (Nedd8 ultimate buster 1) is an adaptor protein which negatively regulates the ubiquitin-like protein Nedd8 as well as neddylated proteins levels through…”
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Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma? by Incorvaia, Lorena, Badalamenti, Giuseppe, Rinaldi, Gaetana, Iovanna, Juan Lucio, Olive, Daniel, Swayden, Mirna, Terruso, Lidia, Vincenzi, Bruno, Fulfaro, Fabio, Bazan, Viviana, Russo, Antonio, Fanale, Daniele

“…Background: The immune response in melanoma patients is locally affected by presence of tumor-infiltrating lymphocytes (TILs), generally divided into brisk,…”
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ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity by Taieb, David, Roignot, Julie, André, Frédéric, Garcia, Stéphane, Masson, Bénédicte, Pierres, Anne, Iovanna, Juan-Lucio, Soubeyran, Philippe

“…The poor prognosis of pancreatic cancer is due to rapid locoregional invasion, the early development of metastases, and the limited efficacy of current…”
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Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions by Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie

“…Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a…”
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Iron-Sensitive Prodrugs That Trigger Active Ferroptosis in Drug-Tolerant Pancreatic Cancer Cells by Antoszczak, Michał, Müller, Sebastian, Cañeque, Tatiana, Colombeau, Ludovic, Dusetti, Nelson, Santofimia-Castaño, Patricia, Gaillet, Christine, Puisieux, Alain, Iovanna, Juan Lucio, Rodriguez, Raphaël

“…Persister cancer cells represent rare populations of cells resistant to therapy. Cancer cells can exploit epithelial-mesenchymal plasticity to adopt a…”
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Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer by Jiang, Pei-Hong, Motoo, Yoshiharu, Garcia, Stéphane, Iovanna, Juan Lucio, Pébusque, Marie-Josèphe, Sawabu, Norio

“…AIM： Overexpression of tumor protein p53-induced nudear protein 1 （TP53INP1） induces G1 cell cycle arrest and increases p53-mediated apoptosis. To clarify the…”
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Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma by Guillaumond, Fabienne, Bidaut, Ghislain, Ouaissi, Mehdi, Servais, Stéphane, Gouirand, Victoire, Olivares, Orianne, Lac, Sophie, Borge, Laurence, Roques, Julie, Gayet, Odile, Pinault, Michelle, Guimaraes, Cyrille, Nigri, Jérémy, Loncle, Céline, Lavaut, Marie-Noëlle, Garcia, Stéphane, Tailleux, Anne, Staels, Bart, Calvo, Ezequiel, Tomasini, Richard, Iovanna, Juan Lucio, Vasseur, Sophie

“…The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by a profound desmoplasia, which forces proliferating tumor cells to…”
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Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma by Guillaumond, Fabienne, Leca, Julie, Olivares, Orianne, Lavaut, Marie-Noëlle, Vidal, Nicolas, Berthezène, Patrice, Dusetti, Nelson Javier, Loncle, Céline, Calvo, Ezequiel, Turrini, Olivier, lovanna, Juan Lucio, Tomasini, Richard, Vasseur, Sophie

“…Pancreatic ductal adenocarcinoma is one of the most intractable and fatal cancer. The decreased blood vessel density displayed by this tumor not only favors…”
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Pancreatic tumor cell metabolism: Focus on glycolysis and its connected metabolic pathways by Guillaumond, Fabienne, Iovanna, Juan Lucio, Vasseur, Sophie

“…•Anatomopathologic features of PDAC force metabolic adaptation of tumor cells.•Hypoxic pancreatic cancer cells combine glycolysis and glutaminolysis.•Hypoxia…”
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REG3β modifies cell tumor function by impairing extracellular vesicle uptake by Bonjoch, Laia, Gironella, Meritxell, Iovanna, Juan Lucio, Closa, Daniel

“…Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-sized membrane vesicles containing proteins and nucleic acids, which act as…”
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Prognostic Role of Plasma PD-1, PD-L1, pan-BTN3As and BTN3A1 in Patients Affected by Metastatic Gastrointestinal Stromal Tumors: Can Immune Checkpoints Act as a Sentinel for Short-Term Survival? by Fanale, Daniele, Incorvaia, Lorena, Badalamenti, Giuseppe, De Luca, Ida, Algeri, Laura, Bonasera, Annalisa, Corsini, Lidia Rita, Brando, Chiara, Russo, Antonio, Iovanna, Juan Lucio, Bazan, Viviana

“…Gastrointestinal stromal tumors (GISTs) represent 1% of all primary gastrointestinal tumors. Immune surveillance is often overcome by cancer cells due to the…”
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DJ-1/PARK7 Is an Important Mediator of Hypoxia-Induced Cellular Responses by Vasseur, Sophie, Afzal, Samia, Tardivel-Lacombe, Joël, Park, David S., Iovanna, Juan Lucio, Wah Mak, Tak

“…In cancer, DJ-1/PARK7 acts as an oncogene that drives Akt-mediated cell survival. Although amplification of DJ-1 has been described in several types of tumors,…”
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Baseline plasma levels of soluble PD-1, PD-L1, and BTN3A1 predict response to nivolumab treatment in patients with metastatic renal cell carcinoma: a step toward a biomarker for therapeutic decisions by Incorvaia, Lorena, Fanale, Daniele, Badalamenti, Giuseppe, Porta, Camillo, Olive, Daniel, De Luca, Ida, Brando, Chiara, Rizzo, Mimma, Messina, Carlo, Rediti, Mattia, Russo, Antonio, Bazan, Viviana, Iovanna, Juan Lucio

“…Despite a proportion of renal cancer patients can experiment marked and durable responses to immune-checkpoint inhibitors, the treatment efficacy is widely…”
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An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile by Dhumal, Dinesh, Lan, Wenjun, Ding, Ling, Jiang, Yifan, Lyu, Zhenbin, Laurini, Erik, Marson, Domenico, Tintaru, Aura, Dusetti, Nelson, Giorgio, Suzanne, Iovanna, Juan Lucio, Pricl, Sabrina, Peng, Ling

“…Gene therapy using small interfering RNA (siRNA) is emerging as a novel therapeutic approach to treat various diseases. However, safe and efficient siRNA…”
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EVOO's Effects on Incretin Production: Is There a Rationale for a Combination in T2DM Therapy? by Amodeo, Simona, Mirarchi, Luigi, Seidita, Aurelio, Citarrella, Roberto, Licata, Anna, Soresi, Maurizio, Iovanna, Juan Lucio, Giannitrapani, Lydia

“…Type 2 diabetes mellitus (T2DM) is a serious public health concern as it is one of the most common chronic diseases worldwide due to social and economic…”
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p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis by Vasseur, Sophie, Hoffmeister, Albrecht, Garcia-Montero, Andrés, Mallo, Gustavo Vidal, Feil, Robert, Kühbandner, Susanne, Dagorn, Jean-Charles, Iovanna, Juan Lucio

“…p8 is a stress-induced DNA-binding protein, biochemically related to the architectural chromatin binding HMG protein family and whose function is presently…”
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Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis by Hamidi, Tewfik, Algül, Hana, Cano, Carla Eliana, Sandi, Maria José, Molejon, Maria Inés, Riemann, Marc, Calvo, Ezequiel Luis, Lomberk, Gwen, Dagorn, Jean-Charles, Weih, Falk, Urrutia, Raul, Schmid, Roland Michael, Iovanna, Juan Lucio

“…Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all cancers and shows remarkable resistance to cell stress. Nuclear protein 1 (Nupr1),…”
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Low plasma PD-L1 levels, early tumor onset and absence of peritoneal carcinomatosis improve prognosis of women with advanced high-grade serous ovarian cancer by Fanale, Daniele, Brando, Chiara, Corsini, Lidia Rita, Cutaia, Sofia, Di Donna, Mariano Catello, Randazzo, Ugo, Filorizzo, Clarissa, Lisanti, Chiara, Magrin, Luigi, Gurrera, Vittorio, Romano, Raffaella, Dimino, Alessandra, Bazan Russo, Tancredi Didier, Olive, Daniel, Vieni, Salvatore, Pantuso, Gianni, Giordano, Antonio, Chiantera, Vito, Russo, Antonio, Bazan, Viviana, Iovanna, Juan Lucio

“…The most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is…”
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