Search Results - "IOVANNA, JUAN L"

Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness by Leca, Julie, Martinez, Sébastien, Lac, Sophie, Nigri, Jérémy, Secq, Véronique, Rubis, Marion, Bressy, Christian, Sergé, Arnauld, Lavaut, Marie-Noelle, Dusetti, Nelson, Loncle, Céline, Roques, Julie, Pietrasz, Daniel, Bousquet, Corinne, Garcia, Stéphane, Granjeaud, Samuel, Ouaissi, Mehdi, Bachet, Jean Baptiste, Brun, Christine, Iovanna, Juan L, Zimmermann, Pascale, Vasseur, Sophie, Tomasini, Richard

“…The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA), and specific conditions in…”
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Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma by Neira, José L., Bintz, Jennifer, Arruebo, María, Rizzuti, Bruno, Bonacci, Thomas, Vega, Sonia, Lanas, Angel, Velázquez-Campoy, Adrián, Iovanna, Juan L., Abián, Olga

“…Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and regulatory functions. Often associated with human diseases, they…”
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Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3 by Rizzuti, Bruno, Iovanna, Juan L, Neira, José L

“…The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear…”
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Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation by Aden, Konrad, Rehman, Ateequr, Falk-Paulsen, Maren, Secher, Thomas, Kuiper, Jan, Tran, Florian, Pfeuffer, Steffen, Sheibani-Tezerji, Raheleh, Breuer, Alexandra, Luzius, Anne, Jentzsch, Marlene, Häsler, Robert, Billmann-Born, Susanne, Will, Olga, Lipinski, Simone, Bharti, Richa, Adolph, Timon, Iovanna, Juan L., Kempster, Sarah L., Blumberg, Richard S., Schreiber, Stefan, Becher, Burkhard, Chamaillard, Mathias, Kaser, Arthur, Rosenstiel, Philip

“…A plethora of functional and genetic studies have suggested a key role for the IL-23 pathway in chronic intestinal inflammation. Currently, pathogenic actions…”
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Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells by Salazar, María, Carracedo, Arkaitz, Salanueva, Iñigo J, Hernández-Tiedra, Sonia, Lorente, Mar, Egia, Ainara, Vázquez, Patricia, Blázquez, Cristina, Torres, Sofía, García, Stephane, Nowak, Jonathan, Fimia, Gian María, Piacentini, Mauro, Cecconi, Francesco, Pandolfi, Pier Paolo, González-Feria, Luis, Iovanna, Juan L, Guzmán, Manuel, Boya, Patricia, Velasco, Guillermo

“…Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that…”
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Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B by Santofimia-Castaño, Patricia, Rizzuti, Bruno, Pey, Ángel L., Soubeyran, Philippe, Vidal, Miguel, Urrutia, Raúl, Iovanna, Juan L., Neira, José L.

“…Intrinsically disordered proteins (IDPs) are ubiquitous in eukaryotes, and they are often associated with diseases in humans. The protein NUPR1 is a…”
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Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age‐related bone loss in male mice by Murayama, Masatoshi, Hirata, Hirohito, Shiraki, Makoto, Iovanna, Juan L., Yamaza, Takayoshi, Kukita, Toshio, Komori, Toshihisa, Moriishi, Takeshi, Ueno, Masaya, Morimoto, Tadatsugu, Mawatari, Masaaki, Kukita, Akiko

“…Nuclear protein 1 (NUPR1) is a stress‐induced protein activated by various stresses, such as inflammation and oxidative stress. We previously reported that…”
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Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes by Carracedo, Arkaitz, Gironella, Meritxell, Lorente, Mar, Garcia, Stephane, Guzmán, Manuel, Velasco, Guillermo, Iovanna, Juan L

“…Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is of especial interest to set new strategies aimed at improving the…”
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Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells by Ko, Eun-Ji, Ock, Mee-Sun, Choi, Yung-Hyun, Iovanna, Juan L, Mun, Seyoung, Han, Kyudong, Kim, Heui-Soo, Cha, Hee-Jae

“…Human endogenous retroviruses (HERVs) are suggested to be involved in the development of certain diseases, especially cancers. To elucidate the function of…”
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Nupr1: The Swiss-knife of cancer by Cano, Carla E., Hamidi, Tewfik, Sandi, Maria José, Iovanna, Juan L.

“…Nupr1 is a small, highly basic and loosely folded multifunctional protein whose expression is induced by several stresses. Its relation to cancer was first…”
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Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development by Gironella, Meritxell, Seux, Mylène, Xie, Min-Jue, Cano, Carla, Tomasini, Richard, Gommeaux, Julien, Garcia, Stephane, Nowak, Jonathan, Yeung, Man Lung, Jeang, Kuan-Teh, Chaix, Amandine, Fazli, Ladan, Motoo, Yoshiharu, Wang, Qing, Rocchi, Palma, Russo, Antonio, Gleave, Martin, Dagorn, Jean-Charles, Iovanna, Juan L, Carrier, Alice, Pébusque, Marie-Josèphe, Dusetti, Nelson J

“…Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53…”
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The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3 by Neira, José L, Rizzuti, Bruno, Jiménez-Alesanco, Ana, Abián, Olga, Velázquez-Campoy, Adrián, Iovanna, Juan L

“…Numerous carrier proteins intervene in protein transport from the cytoplasm to the nucleus in eukaryotic cells. One of those is importin α, with several human…”
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KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells by Mathison, Angela J., Kerketta, Romica, de Assuncao, Thiago Milech, Leverence, Elise, Zeighami, Atefeh, Urrutia, Guillermo, Stodola, Timothy J., di Magliano, Marina Pasca, Iovanna, Juan L., Zimmermann, Michael T., Lomberk, Gwen, Urrutia, Raul

“…Abstract Background Pancreatic ductal adenocarcinoma initiation is most frequently caused by Kras mutations. Results Here, we apply biological, biochemical,…”
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Factors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression by Iovanna, Juan L., Closa, Daniel

“…The REG3β protein was identified more than 2 decades ago, but its role in PDAC development was only recently reported. In Pancreatic Ductal Adenocarcinoma…”
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The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells by Ropolo, Alejandro, Grasso, Daniel, Pardo, Romina, Sacchetti, Maria L., Archange, Cendrine, Re, Andrea Lo, Seux, Mylene, Nowak, Jonathan, Gonzalez, Claudio D., Iovanna, Juan L., Vaccaro, Maria I.

“…Autophagy is a degradation process of cytoplasmic cellular constituents, which serves as a survival mechanism in starving cells, and it is characterized by…”
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The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells by Carracedo, Arkaitz, Lorente, Mar, Egia, Ainara, Blázquez, Cristina, García, Stephane, Giroux, Valentin, Malicet, Cedric, Villuendas, Raquel, Gironella, Meritxell, González-Feria, Luis, Piris, Miguel Ángel, Iovanna, Juan L., Guzmán, Manuel, Velasco, Guillermo

“…One of the most exciting areas of current research in the cannabinoid field is the study of the potential application of these compounds as antitumoral drugs…”
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Targeting heat shock response pathways to treat pancreatic cancer by Xia, Yi, Rocchi, Palma, Iovanna, Juan L., Peng, Ling

“…Pancreatic cancer belongs to the group of extremely aggressive human cancers; conventional cancer treatments have little impact. Increasing understanding of…”
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TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity by Tomasini, Richard, Tsuchihara, Katsuya, Tsuda, Chiharu, Lau, Suzanne K, Wilhelm, Margareta, Ruffini, Alessandro, Tsao, Ming-sound, Iovanna, Juan L, Jurisicova, Andrea, Melino, Gerry, Mak, Tak W

“…The role of various p73 isoforms in tumorigenesis has been controversial. However, as we have recently shown, the generation of TAp73-deficient (TAp73⁻/⁻) mice…”
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OncoSNIPE® Study Protocol, a study of molecular profiles associated with development of resistance in solid cancer patients by Vachenc, Sébastien, Gobbo, Jessica, Moujarrebe, Sarah El, Desmoulins, Isabelle, Gilabert, Marine, Beau-Faller, Michelle, Mitry, Emmanuel, Girard, Nicolas, Bertaut, Aurélie, Dusetti, Nelson, Iovanna, Juan L, Yousfi, Rahima, Pierrat, Fabien, Bruno, Roman, Cueff, Adèle, Boidot, Romain, Genne, Philippe

“…Nowadays, evaluation of the efficacy and the duration of treatment, in context of monitoring patients with solid tumors, is based on the RECIST methodology…”
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Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death by HAMIDI, Tewfik, CANO, Carla E, CARRACEDO, Arkaitz, VELASCO, Guillermo, LOVANNA, Juan L, GRASSO, Daniel, NOE GARCIA, Maria, SANDI, Maria Jose, CALVO, Ezequiel L, DAGORN, Jean-Charles, LOMBERK, Gwen, URRUTIA, Raul, GORUPPI, Sandro

“…The limited supply of oxygen and nutrients is thought to result in rigorous selection of cells that will eventually form the tumor. Nupr1 expression pattern…”
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