Search Results - "IOFFE, Sema L"

Chemistry of Six-Membered Cyclic Oxime Ethers. Application in the Synthesis of Bioactive Compounds by Sukhorukov, Alexey Yu, Ioffe, Sema L

“…The chemistry of six-membered cyclic oxime ethers (SCOE) used for organic synthesis is examined. SCOE are promising intermediates for total synthesis…”
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[3+3]-Annulation of Cyclic Nitronates with Vinyl Diazoacetates: Diastereoselective Synthesis of Partially Saturated [1,2]Oxazino[2,3- b ][1,2]oxazines and Their Base-Promoted Ring Contraction to Pyrrolo[1,2- b ][1,2]oxazine Derivatives by Antonova, Yulia A, Nelyubina, Yulia V, Ioffe, Sema L, Tabolin, Andrey A

“…A rhodium(II)-catalyzed reaction of cyclic nitronates (5,6-dihydro-4 -1,2-oxazine -oxides) with vinyl diazoacetates proceeds as a [3+3]-annulation producing…”
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Synthesis and Regioselective N‐2 Functionalization of 4‐Fluoro‐5‐aryl‐1,2,3‐NH‐triazoles by Motornov, Vladimir A., Tabolin, Andrey A., Novikov, Roman A., Nelyubina, Yulia V., Ioffe, Sema L., Smolyar, Ivan V., Nenajdenko, Valentine G.

“…A new efficient synthetic route to 4‐fluoro‐5‐aryl‐1,2,3‐NH‐triazoles was elaborated. The reactions of NaN3 with aryl‐substituted α‐fluoronitroalkenes resulted…”
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The Cyclic Nitronate Route to Pharmaceutical Molecules: Synthesis of GSK's Potent PDE4 Inhibitor as a Case Study by Pospelov, Evgeny V, Golovanov, Ivan S, Ioffe, Sema L, Sukhorukov, Alexey Yu

“…An efficient asymmetric synthesis of GlaxoSmithKline's potent PDE4 inhibitor was accomplished in eight steps from a catechol-derived nitroalkene. The key…”
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An Easy Synthesis of Monofluorinated Derivatives of Pyrroles from β-Fluoro-β-Nitrostyrenes by Aldoshin, Alexander S., Tabolin, Andrey A., Ioffe, Sema L., Nenajdenko, Valentine G.

“…The catalyst-free conjugate addition of pyrroles to β-Fluoro-β-nitrostyrenes was investigated. The reaction was found to proceed under solvent-free conditions…”
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Carbon−Carbon Bond Forming Reactions Mediated by Silicon Lewis Acids by Dilman, Alexander D, Ioffe, Sema L

“…This review surveys the data on the behavior of silicon Lewis acids (SLA) of the general formula R3SiX in carbon-carbon bond forming processes. Besides…”
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Diels-Alder reaction of β-fluoro-β-nitrostyrenes with cyclic dienes by Ponomarev, Savva A, Larkovich, Roman V, Aldoshin, Alexander S, Tabolin, Andrey A, Ioffe, Sema L, Groß, Jonathan, Opatz, Till, Nenajdenko, Valentine G

“…The Diels-Alder reaction of β-fluoro-β-nitrostyrenes with cyclic 1,3-dienes was investigated. A series of novel monofluorinated norbornenes was prepared in up…”
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Rearrangement of N‑Oxyenamines and Related Reactions by Tabolin, Andrey A, Ioffe, Sema L

“…Tabolin and Ioffe investigated the synthetic applications of N-vinlyhydroxylamine rearrangements that move with N-O bond cleavage and focused on the…”
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Construction of bis-, tris- and tetrahydrazones by addition of azoalkenes to amines and ammonia by Semakin, Artem N, Kokuev, Aleksandr O, Nelyubina, Yulia V, Sukhorukov, Alexey Yu, Zhmurov, Petr A, Ioffe, Sema L, Tartakovsky, Vladimir A

“…Exhaustive Michael-type alkylations of amines and ammonia with azoalkenes (generated from α-halohydrazones) were demonstrated as an efficient approach to…”
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Catalytic Reductive Recyclization of Functionalized Isoxazoline N‑Oxides to Pyrrolizidine-3-ones by Okladnikov, Ilya V., Aksenova, Svetlana A., Ioffe, Sema L., Sukhorukov, Alexey Yu

“…Pyrrolizidine is among the saturated N-heterocyclic scaffolds most frequently found in natural products and pharmaceutically relevant substances. Herein, a…”
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Michael Addition of P‑Nucleophiles to Conjugated Nitrosoalkenes by Naumovich, Yana A, Ioffe, Sema L, Sukhorukov, Alexey Yu

“…A general approach to various α-phosphorus-substituted oximes (β-oximinoalkyl-substituted phosphonates, phosphine oxides, phosphine–borane complexes, and…”
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Synthesis of Bis(β‐Oximinoalkyl)malonates and Their Catalytic Reductive Cyclization to Piperidines by Pospelov, Evgeny V., Boyko, Yaroslav D., Ioffe, Sema L., Sukhorukov, Alexey Yu

“…Hitherto unknown bis(β‐oximinoalkyl)malonates were demonstrated to be convenient platforms for the synthesis of saturated N‐heterocycles. Upon heterogeneous…”
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Deoxygenative Arylation of 5,6-Dihydro‑4H‑1,2-oxazine‑N‑oxides with Arynes by Lukoyanov, Alexander A., Tabolin, Andrey A., Nelyubina, Yulia V., Ioffe, Sema L., Sukhorukov, Alexey Yu

“…Six-membered cyclic nitronates (5,6-dihydro-4H-1,2-oxazine-N-oxides) react with Kobayashi’s aryne precursors producing 3-(2-hydroxyaryl)-substituted…”
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Sequential Formal [4+1]‐Cycloaddition, C−H Functionalization and Suzuki–Miyaura Cross‐Coupling for the Synthesis of Trisubstituted Isoxazolines by Ushakov, Pavel Yu, Sukhorukov, Alexey Yu, Ioffe, Sema L., Tabolin, Andrey A.

“…Suzuki–Miyaura cross‐coupling reaction of 3‐bromomethyl isoxazolines with arylboronic acids was suggested as final C−C bond forming step in convenient…”
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Deoxygenative Arylation of 5,6-Dihydro-4 H -1,2-oxazine- N -oxides with Arynes by Lukoyanov, Alexander A, Tabolin, Andrey A, Nelyubina, Yulia V, Ioffe, Sema L, Sukhorukov, Alexey Yu

“…Six-membered cyclic nitronates (5,6-dihydro-4 -1,2-oxazine- -oxides) react with Kobayashi's aryne precursors producing 3-(2-hydroxyaryl)-substituted…”
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Interrupted Nef Reaction of Cyclic Nitronates: Diastereoselective Access to Densely Substituted α‑Chloronitroso Compounds by Malykhin, Roman S., Boyko, Yaroslav D., Nelyubina, Yulia V., Ioffe, Sema L., Sukhorukov, Alexey Yu

“…The reaction of cyclic nitronic esters (isoxazoline- and 5,6-dihydro-4H-1,2-oxazine-N-oxides) with hydrochloric acid affords geminal chloronitroso compounds…”
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2,4,9‐Triazaadamantanes with “Clickable” Groups: Synthesis, Structure and Applications as Tripodal Platforms by Semakin, Artem N., Nelyubina, Yulia V., Ioffe, Sema L., Sukhorukov, Alexey Yu

“…2,4,9‐Triazaadamantanes (TRIADs) are promising yet scarcely available, conformationally rigid platforms for potential applications in the design of functional…”
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One‐Pot Synthesis of 3‐(2‐Fluoroalkenyl)indoles by Aldoshin, Alexander S., Tabolin, Andrey A., Ioffe, Sema L., Nenajdenko, Valentine G.

“…An unprecedented one‐pot synthesis of 3‐(fluoroalkenyl)indoles was developed. This process involves a catalyst‐free Michael addition of…”
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Radical Nitration-Debromination of α‑Bromo-α-fluoroalkenes as a Stereoselective Route to Aromatic α‑FluoronitroalkenesFunctionalized Fluorinated Building Blocks for Organic Synthesis by Motornov, Vladimir A, Muzalevskiy, Vasiliy M, Tabolin, Andrey A, Novikov, Roman A, Nelyubina, Yulia V, Nenajdenko, Valentine G, Ioffe, Sema L

“…A new highly efficient method for the synthesis of 2-fluoro-2-nitrostyrenes was described. Radical nitration of readily available 2-bromo-2-fluorostyrenes with…”
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Ring Closure of Nitroalkylmalonates for the Synthesis of Isoxazolines under the Acylation Conditions by Antonova, Yulia A., Nelyubina, Yulia V., Ioffe, Sema L., Sukhorukov, Alexey Yu, Tabolin, Andrey A.

“…Acylation of nitroalkylmalonates was found to yield substituted isoxazoline derivatives. This redox‐neutral transformation has a wide substrate scope and…”
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