Search Results - "INOUE, Tae"

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes by Schaefer, Olaf, Ohtsuki, Sumio, Kawakami, Hirotaka, Inoue, Tae, Liehner, Stephanie, Saito, Asami, Sakamoto, Atsushi, Ishiguro, Naoki, Matsumaru, Takehisa, Terasaki, Tetsuya, Ebner, Thomas

“…The levels of metabolizing enzymes and transporters expressed in hepatocytes are decisive factors for hepatobiliary disposition of most drugs. Induction via…”
Get full text

Association of lethal acquired factor XIII deficiency and type 1 diabetes mellitus with drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms with high levels of serum thymus and activation‐regulated chemokine by Kawai, Rana, Suzuki, So, Tanaka, Akira, Yamazaki, Marina, Inoue, Tae, Katagiri, Kazumoto

Get full text

Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice by Shigeyama, Yutaka, Kobayashi, Toshiyuki, Kido, Yoshiaki, Hashimoto, Naoko, Asahara, Shun-ichiro, Matsuda, Tomokazu, Takeda, Akihiko, Inoue, Tae, Shibutani, Yuki, Koyanagi, Maki, Uchida, Tohru, Inoue, Maki, Hino, Okio, Kasuga, Masato, Noda, Tetsuo

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Establishment of novel meniscal scaffold structures using polyglycolic and poly-l-lactic acids by Murakami, Tomohiko, Otsuki, Shuhei, Nakagawa, Kosuke, Okamoto, Yoshinori, Inoue, Tae, Sakamoto, Yuki, Sato, Hideki, Neo, Masashi

“…The purpose of this study was to evaluate various types of meniscus scaffolds that mimic the meniscus structure, and to establish a novel cell-free meniscus…”
Get full text

CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver by INOUE, Tae, NITTA, Kayoko, SUGIHARA, Kazumi, HORIE, Toru, KITAMURA, Shigeyuki, OHTA, Shigeru

“…Chimeric mice having humanized livers were constructed by transplantation of human hepatocytes. In this study, we investigated whether these mice have a…”
Get full text

Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver by Nurrochmad, Arief, Ishii, Yuji, Nakanoh, Hitomi, Inoue, Tae, Horie, Toru, Sugihara, Kazumi, Ohta, Shigeru, Taketomi, Akinobu, Maehara, Yoshihiko, Yamada, Hideyuki

“…The formation of morphine-3-glucuronide (M-3-G, pharmacologically inactive) and morphine-6-glucuronide (M-6-G, active metabolite) by liver microsomes from…”
Get full text

Effect of intrauterine undernutrition during late gestation on pancreatic β cell mass by Inoue, Tae, Kido, Yoshiaki, Asahara, Shun-ichiro, Matsuda, Tomokazu, Shibutani, Yuki, Koyanagi, Maki, Kasuga, Masato

“…We analyzed the effect of low birth weight on pancreatic β cell mass. We used pregnant C57BL6J mice, and we reduced their food supply by 30% during the late…”
Get full text

The HfCl4-Mediated Diels-Alder Reaction of Furan by Hayashi, Yujiro, Nakamura, Masahiko, Nakao, Shigehiro, Inoue, Tae, Shoji, Mitsuru

“…High yields and high endo selectivity of the cycloadducts formed from the Diels–Alder reaction of furan or substituted furans occurs with an HfCl4 catalyst…”
Get full text

Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis by Inoue-Narita, Tae, Hamada, Koichi, Sasaki, Takehiko, Hatakeyama, Sachiko, Fujita, Sachiko, Kawahara, Kohichi, Sasaki, Masato, Kishimoto, Hiroyuki, Eguchi, Satoshi, Kojima, Itaru, Beermann, Friedrich, Kimura, Tetsunori, Osawa, Masatake, Itami, Satoshi, Mak, Tak Wah, Nakano, Toru, Manabe, Motomu, Suzuki, Akira

“…Phosphate and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor gene inactivated in numerous sporadic cancers, including melanomas. To…”
Get full text

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver by Inoue, Tae, Sugihara, Kazumi, Ohshita, Hiroki, Horie, Toru, Kitamura, Shigeyuki, Ohta, Shigeru

“…Chimeric mice, constructed by transplanting human hepatocytes, are useful for predicting the human metabolism of drug candidates. In this study, we…”
Get full text

Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver by KITAMURA, Shigeyuki, NITTA, Kayoko, TAYAMA, Yoshitaka, TANOUE, Chiaki, SUGIHARA, Kazumi, INOUE, Tae, HORIE, Toru, OHTA, Shigeru

“…Aldehyde oxidase-mediated oxidation of N 1 -methylnicotinamide to N 1 -methyl-2-pyridine-5-carboxamide (2-PY) and N 1 -methyl-4-pyridone-5-carboxamide (4-PY)…”
Get full text

Spontaneous regression of Merkel cell carcinoma: a comparative study of TUNEL index and tumor-infiltrating lymphocytes between spontaneous regression and non-regression group by Inoue, Tae, Yoneda, Kozo, Manabe, Motomu, Demitsu, Toshio

“…Some Merkel cell carcinomas (MCC) have been reported to regress spontaneously. To clarify the mechanisms of spontaneous regression (SR) of MCC, we analyzed the…”
Get full text

Induction of gene encoding FABP4 in Pten-null keratinocytes by Tsuda, Masaaki, Inoue-Narita, Tae, Suzuki, Akira, Itami, Satoshi, Blumenberg, Miroslav, Manabe, Motomu

“…Keratinocyte-specific Pten-null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that…”
Get full text

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities by Ohtsuki, Sumio, Schaefer, Olaf, Kawakami, Hirotaka, Inoue, Tae, Liehner, Stephanie, Saito, Asami, Ishiguro, Naoki, Kishimoto, Wataru, Ludwig-Schwellinger, Eva, Ebner, Thomas, Terasaki, Tetsuya

“…The purpose of the present study was to determine the absolute protein expression levels of multiple drug-metabolizing enzymes and transporters in 17 human…”
Get full text

Activation of Mast Cells within a Tumor of Angiosarcoma: Ultrastructural Study of Five Cases by Demitsu, Toshio, Inoue, Tae, Kakurai, Maki, Kiyosawa, Tomoharu, Yoneda, Kozo, Manabe, Motomu

“…The accumulation of mast cells around tumors is a well‐recognized phenomenon in a number of malignancies, including basal cell carcinoma, melanoma, and breast…”
Get full text

Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography by Sakamoto, Atsushi, Matsumaru, Takehisa, Ishiguro, Naoki, Schaefer, Olaf, Ohtsuki, Sumio, Inoue, Tae, Kawakami, Hirotaka, Terasaki, Tetsuya

“…Mass spectrometry (MS)-based multiplexed multiple reaction monitoring quantification of proteins has recently evolved as a versatile tool for accurate,…”
Get more information

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver by Tae INOUE, Kazumi SUGIHARA, Hiroki OHSHITA, Toru HORIE, Shigeyuki KITAMURA, Shigeru OHTA

“…[Summary]:Chimeric mice, constructed by transplanting human hepatocytes, are useful for predicting the human metabolism of drug candidates. In this study, we…”
Get full text

The influence of traditional Chinese herbal drugs on serum 1,5-anhydroglucitol levels by Kawasaki, Takahiro, Yamanouchi, Toshikazu, Kashiwabara, Akiko, Inoue, Tae, Yoshimura, Tomoe, Fujimori, Sin, Tanabe, Toshio, Aiso, Yoshitaka

“…The serum concentration of 1,5-anhydroglucitol (1,5-AG), a polyol which originates mainly in the diet, is used in Japan as a new marker for glycemia. To…”
Get full text

A Case of Otomycosis Caused by Aspergillus sclerotiorum by Harima, Natsuko, Inoue, Tae, Kubota, Takashi, Okada, Osamu, Ansai, Shin‐ichi, Manabe, Motomu, Ichinoe, Masakatsu, Kasai, Tatsuya

Get full text

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS by Ohtsuki, Sumio, Kawakami, Hirotaka, Inoue, Tae, Nakamura, Kenji, Tateno, Chise, Katsukura, Yuki, Obuchi, Wataru, Uchida, Yasuo, Kamiie, Junichi, Horie, Toru, Terasaki, Tetsuya

“…Chimeric mice with humanized liver (PXB mice) have been generated by transplantation of urokinase-type plasminogen activator/severe combined immunodeficiency…”
Get full text