Search Results - "INOUE, Ikuo"

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and subsequent mitochondrial accumulation in human fibroblasts by Takenaka, Yasuhiro, Inoue, Ikuo, Nakano, Takanari, Ikeda, Masaaki, Kakinuma, Yoshihiko

“…Proteolytic activity declines with age, resulting in the accumulation of aggregated proteins in aged organisms. To investigate how disturbance in proteostasis…”
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Temporal inhibition of the electron transport chain attenuates stress‐induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts by Takenaka, Yasuhiro, Inoue, Ikuo, Hirasaki, Masataka, Ikeda, Masaaki, Kakinuma, Yoshihiko

“…We previously developed a stress‐induced premature senescence (SIPS) model in which normal human fibroblast MRC‐5 cells were treated with either the proteasome…”
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Neurofibromatosis Type 1 with Concurrent Multiple Endocrine Disorders: Adenomatous Goiter, Primary Hyperparathyroidism, and Acromegaly by Yasuda, Shigemitsu, Inoue, Ikuo, Shimada, Akira

“…We encountered a 70-year-old Japanese woman with neurofibromatosis type 1 (NF1) who had a history of pheochromocytoma and concurrently developed adenomatous…”
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Evolocumab vs. Ezetimibe in Statin-Intolerant Hyperlipidemic Japanese Patients: Phase 3 GAUSS-4 Trial by Koba, Shinji, Inoue, Ikuo, Cyrille, Marcoli, Lu, Chen, Inomata, Hyoe, Shimauchi, Junichiro, Kajinami, Kouji

“…Aim: In patients with hyperlipidemia, intolerance to statins presents a challenge in reducing the risk of events associated with cardiovascular disease. This…”
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A Newly Integrated Model for Intestinal Cholesterol Absorption and Efflux Reappraises How Plant Sterol Intake Reduces Circulating Cholesterol Levels by Nakano, Takanari, Inoue, Ikuo, Murakoshi, Takayuki

“…Cholesterol homeostasis is maintained through a balance of de novo synthesis, intestinal absorption, and excretion from the gut. The small intestine…”
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Shared Mechanisms in Pparγ1sv and Pparγ2 Expression in 3T3-L1 Cells: Studies on Epigenetic and Positive Feedback Regulation of Pparγ during Adipogenesis by Takenaka, Yasuhiro, Kakinuma, Yoshihiko, Ikeda, Masaaki, Inoue, Ikuo

“…We have previously reported the identification of a novel splicing variant of the mouse peroxisome proliferator-activated receptor- ( ), referred to as . This…”
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Efficacy of dapagliflozin versus sitagliptin on cardiometabolic risk factors in Japanese patients with type 2 diabetes: a prospective, randomized study (DIVERSITY-CVR) by Fuchigami, Ayako, Shigiyama, Fumika, Kitazawa, Toru, Okada, Yosuke, Ichijo, Takamasa, Higa, Mariko, Hiyoshi, Toru, Inoue, Ikuo, Iso, Kaoru, Yoshii, Hidenori, Hirose, Takahisa, Kumashiro, Naoki

“…Few prospective studies have compared the cardiovascular benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP-4)…”
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Clinical characteristics of anti-glutamic acid decarboxylase antibody-positive fulminant type 1 diabetes by Saito, Daigo, Oikawa, Yoichi, Mizutani, Gen, Inoue, Kazuyuki, Hatano, Masako, Inoue, Ikuo, Noda, Mitsuhiko, Shimada, Akira

“…This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify…”
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Combination of anti‐CD25 antibody and poly I:C treatment in pregnant NOD mice may be used as ‘pregnancy‐related’ type 1 diabetes model by Shimada, Akira, Toda, Kyoko, Inoue, Ikuo, Yamada, Taketo, Oikawa, Yoichi

“…ABSTRACT Aims/Introduction Some women develop type 1 diabetes during pregnancy or immediately after delivery. However, the underlying pathophysiology remains…”
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Efficacy and Safety of 5-Aminolevulinic Acid Combined with Iron on Skeletal Muscle Mass Index and Physical Performance of Patients with Sarcopenia: A Multicenter, Double-Blinded, Randomized-Controlled Trial (ALADDIN Study) by Tamura, Yoshifumi, Kaga, Hideyoshi, Abe, Yasuko, Yoshii, Hidenori, Seino, Hiroaki, Hiyoshi, Toru, Kuribayashi, Nobuichi, Inoue, Ikuo, Watada, Hirotaka

“…Sarcopenia is a geriatric syndrome characterized by decreased physical performance, muscle mass, and strength. Since the intake of 5-aminolevulinic acid (ALA)…”
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Free immunoglobulin light chain: Its biology and implications in diseases by Nakano, Takanari, Matsui, Masanori, Inoue, Ikuo, Awata, Takuya, Katayama, Shigehiro, Murakoshi, Takayuki

“…Immunoglobulin light chain (IgLC) is a component of antibodies, but its free form is observed in the circulation, which originates from 10 to 40% excess…”
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HLA typing of patients who developed subacute thyroiditis and Graves' disease after SARS-CoV-2 vaccination: a case report by Yasuda, Shigemitsu, Suzuki, Seiya, Yanagisawa, Shinnosuke, Morita, Hideo, Haisa, Akifumi, Satomura, Atsushi, Nakajima, Ritsuko, Oikawa, Yoichi, Inoue, Ikuo, Shimada, Akira

“…Cases of subacute thyroiditis (SAT) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination have been reported. A human leukocyte…”
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Statin Intolerance Clinical Guide 2018 by Kajinami, Kouji, Tsukamoto, Kazuhisa, Koba, Shinji, Inoue, Ikuo, Yamakawa, Masashi, Suzuki, Shigeaki, Hamano, Tadanori, Saito, Hidetsugu, Saito, Yoshiro, Masuda, Satohiro, Nakayama, Takeo, Okamura, Tomonori, Yamashita, Shizuya, Kagawa, Tatehiro, Kaneyama, Junji, Kuriyama, Akira, Tanaka, Rumi, Hirata, Aya, Statin Intolerance Clinical Guide Working Group; The Japan Society of Hepatology, Japanese Society of Neurology, Japan Atherosclerosis Society, The Japanese Society for the Study of Xenobiotics

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Bodyweight threshold for sudden onset of ketosis might exist in ketosis‐prone type 2 diabetes patients by Satomura, Atsushi, Oikawa, Yoichi, Haisa, Akifumi, Inoue, Ikuo, Noda, Mitsuhiko, Shimada, Akira

“…Ketosis‐prone type 2 diabetes is recognized as atypical diabetes. These patients are often male, characterized by obesity, sudden onset of ketosis and a…”
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Weight control before and during pregnancy for patients with gestational diabetes mellitus by Yasuda, Shigemitsu, Iuchi, Takujiro, Goto, Atsushi, Katanoda, Kota, Iida, Shinichiro, Oikawa, Yoichi, Namba, Akira, Isshiki, Masashi, Inoue, Ikuo, Kamei, Yoshimasa, Shimada, Akira, Noda, Mitsuhiko

“…Aims/Introduction The aim of the present study was to examine the associations of pregestational body mass index (BMI) and gestational weight change with…”
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A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes by AWATA, Takuya, INOUE, Kiyoaki, KURIHARA, Susumu, OHKUBO, Tomoko, WATANABE, Masaki, INUKAI, Kouichi, INOUE, Ikuo, KATAYAMA, Shigehiro

“…A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes Takuya Awata , Kiyoaki Inoue ,…”
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Lipoprotein Profiles before Heparin Administration in Patients with or without Coronary Thrombosis Following Atherosclerosis by Koizumi, Tomomi, Kaneda, Hideaki, Komiyama, Nobuyuki, Inoue, Ikuo, Muramatsu, Toshihiro, Nakajima, Katsuyuki

“…Objective: The correlation between lipoproteins and arterial thrombosis is not fully elucidated, and no data exist in terms of lipoprotein profiles before…”
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Clinical characterization of patients with primary aldosteronism plus subclinical Cushing's syndrome by Yasuda, Shigemitsu, Hikima, Yusuke, Kabeya, Yusuke, Iida, Shinichiro, Oikawa, Yoichi, Isshiki, Masashi, Inoue, Ikuo, Shimada, Akira, Noda, Mitsuhiko

“…Primary aldosteronism (PA) plus subclinical Cushing's syndrome (SCS), PASCS, has occasionally been reported. We aimed to clinically characterize patients with…”
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Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice by Sakai, Gota, Inoue, Ikuo, Suzuki, Tokuko, Sumita, Takashi, Inukai, Kouichi, Katayama, Shigehiro, Awata, Takuya, Yamada, Tetsuya, Asano, Tomoichiro, Katagiri, Hideki, Noda, Mitsuhiko, Shimada, Akira, Ono, Hiraku

“…Abstract Insulin suppresses glucose output from the liver via Akt activation; however, which substrate of Akt plays the major role in transducing this effect…”
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Luminal plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine by Nakano, Takanari, Inoue, Ikuo, Takenaka, Yasuhiro, Ikegami, Yuichi, Kotani, Norihiro, Shimada, Akira, Noda, Mitsuhiko, Murakoshi, Takayuki

“…Plant sterols are used as food additives to reduce intestinal cholesterol absorption. They also increase fecal neutral sterol (FNS) excretion irrespective of…”
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