Search Results - "INOKUCHI, Junichi"

An oral first‐in‐class small molecule RSK inhibitor suppresses AR variants and tumor growth in prostate cancer by Ushijima, Miho, Shiota, Masaki, Matsumoto, Takashi, Kashiwagi, Eiji, Inokuchi, Junichi, Eto, Masatoshi

“…Ribosomal S6 kinase has been shown to play a key role in cellular resistance to endocrine therapy in prostate cancer through its regulation of YB‐1/androgen…”
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Activators and Inhibitors of Protein Kinase C (PKC): Their Applications in Clinical Trials by Kawano, Takahito, Inokuchi, Junichi, Eto, Masatoshi, Murata, Masaharu, Kang, Jeong-Hun

“…Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation…”
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Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer by Kawano, Takahito, Inokuchi, Junichi, Eto, Masatoshi, Murata, Masaharu, Kang, Jeong-Hun

“…Protein kinase C (PKC) is a large family of calcium- and phospholipid-dependent serine/threonine kinases that consists of at least 11 isozymes. Based on their…”
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Management of bladder cancer in older patients by Hatakeyama, Shingo, Narita, Shintaro, Okita, Kazutaka, Narita, Takuma, Iwamura, Hiromichi, Fujita, Naoki, Inokuchi, Junichi, Matsui, Yoshiyuki, Kitamura, Hiroshi, Ohyama, Chikara

“…Abstract Evidence has shown that patients with bladder cancer are diagnosed at a much older age compared with those with other cancers. Given that…”
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Collateral resistance to taxanes in enzalutamide‐resistant prostate cancer through aberrant androgen receptor and its variants by Shiota, Masaki, Dejima, Takashi, Yamamoto, Yoshiaki, Takeuchi, Ario, Imada, Kenjiro, Kashiwagi, Eiji, Inokuchi, Junichi, Tatsugami, Katsunori, Kajioka, Shunichi, Uchiumi, Takeshi, Eto, Masatoshi

“…Currently, the optimal sequential use of androgen receptor (AR) axis‐targeted agents and taxane chemotherapies remains undetermined. We aimed to elucidate the…”
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Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine by Tsukahara, Shigehiro, Shiota, Masaki, Takamatsu, Dai, Nagakawa, Shohei, Matsumoto, Takashi, Kiyokoba, Ryo, Yagi, Mikako, Setoyama, Daiki, Noda, Nozomi, Matsumoto, Shinya, Hayashi, Tetsutaro, Contreras-Sanz, Alberto, Black, Peter C., Inokuchi, Junichi, Kohashi, Kenichi, Oda, Yoshinao, Uchiumi, Takeshi, Eto, Masatoshi, Kang, Dongchon

“…Chemotherapy is a standard therapy for muscle-invasive bladder cancer (MIBC). However, genomic alterations associated with chemotherapy sensitivity in MIBC…”
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Potential Role for YB-1 in Castration-Resistant Prostate Cancer and Resistance to Enzalutamide Through the Androgen Receptor V7 by Shiota, Masaki, Fujimoto, Naohiro, Imada, Kenjiro, Yokomizo, Akira, Itsumi, Momoe, Takeuchi, Ario, Kuruma, Hidetoshi, Inokuchi, Junichi, Tatsugami, Katsunori, Uchiumi, Takeshi, Oda, Yoshinao, Naito, Seiji

“…Although androgen deprivation therapy for advanced prostate cancer initially exerts excellent anticancer effects, most prostate cancer treated with androgen…”
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Fusion‐targeted biopsy significantly improves prostate cancer detection in biopsy‐naïve men by Blas, Leandro, Shiota, Masaki, Tsukahara, Shigehiro, Goto, Shunsuke, Kinoshita, Fumio, Matsumoto, Takashi, Monji, Keisuke, Kashiwagi, Eiji, Inokuchi, Junichi, Eto, Masatoshi

“…Objective The precise diagnosis of prostate cancer (PC) is crucial to avoid underdiagnosis, overdiagnosis, and overtreatment. We aimed to compare clinically…”
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Impact of nerve sparing in robot‐assisted radical prostatectomy on the risk of positive surgical margin and biochemical recurrence by Komori, Hiroki, Blas, Leandro, Shiota, Masaki, Takamatsu, Dai, Matsumoto, Takashi, Lee, Ken, Monji, Keisuke, Kashiwagi, Eiji, Inokuchi, Junichi, Eto, Masatoshi

“…Objectives Nerve sparing may increase positive surgical margin rate during radical prostatectomy. Our objective was to analyze the positive surgical margin…”
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Comparison of the medical costs between active surveillance and other treatments for early prostate cancer in Japan using data from the PRIAS‐JAPAN study by Kato, Takuma, Yokomizo, Akira, Matsumoto, Ryuji, Tohi, Yoichiro, Miyakawa, Jimpei, Mitsuzuka, Koji, Sasaki, Hiroshi, Inokuchi, Junichi, Matsumura, Masafumi, Sakamoto, Shinichi, Kinoshita, Hidefumi, Fukuhara, Hiroshi, Kamiya, Naoto, Kimura, Ryu, Nitta, Masahiro, Okuno, Hiroshi, Akakura, Koichiro, Kakehi, Yoshiyuki, Sugimoto, Mikio

“…Objectives To compare the medical costs of active surveillance with those of robot‐assisted laparoscopic prostatectomy, brachytherapy, intensity‐modulated…”
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Identification of Activated Protein Kinase Cα (PKCα) in the Urine of Orthotopic Bladder Cancer Xenograft Model as a Potential Biomarker for the Diagnosis of Bladder Cancer by Kawano, Takahito, Tachibana, Yoko, Inokuchi, Junichi, Kang, Jeong-Hun, Murata, Masaharu, Eto, Masatoshi

“…Bladder cancer has a high recurrence rate; therefore, frequent and effective monitoring is essential for disease management. Cystoscopy is considered the gold…”
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Impact of adherence to criteria on oncological outcomes of radical prostatectomy in patients opting for active surveillance: data from the PRIAS-JAPAN study by Tohi, Yoichiro, Kato, Takuma, Miyakawa, Jimpei, Matsumoto, Ryuji, Sasaki, Hiroshi, Mitsuzuka, Koji, Inokuchi, Junichi, Matsumura, Masafumi, Yokomizo, Akira, Kinoshita, Hidefumi, Hara, Isao, Kawamura, Norihiko, Hashimoto, Kohei, Inoue, Masaharu, Teishima, Jun, Kanno, Hidenori, Fukuhara, Hiroshi, Maruyama, Satoru, Sakamoto, Shinichi, Saito, Toshihiro, Kakehi, Yoshiyuki, Sugimoto, Mikio

“…Abstract Objectives This study aimed to evaluate whether oncological outcomes of radical prostatectomy differ depending on adherence to the criteria in…”
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Activated protein kinase C-alpha as a simple test for urothelial cancer screening by Inokuchi, Junichi, Murata, Masaharu, Kawano, Takahito, Kang, Jeong-Hun, Kinoshita, Fumio, Matsumoto, Takashi, Monji, Keisuke, Kashiwagi, Eiji, Takeuchi, Ario, Shiota, Masaki, Eto, Masatoshi

“…e16552 Background: The development of a non-invasive, highly predictive diagnostic test for urothelial cancer (UC) would greatly benefit patients. Although…”
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Clinical advantages of robot‐assisted partial nephrectomy versus laparoscopic partial nephrectomy in terms of global and split renal functions: A propensity score‐matched comparative analysis by Kobayashi, Satoshi, Mutaguchi, Jun, Kashiwagi, Eiji, Takeuchi, Ario, Shiota, Masaki, Inokuchi, Junichi, Eto, Masatoshi

“…Objectives To identify predictors of renal function preservation, and to compare the global and split renal function outcomes of robot‐assisted partial…”
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High‐throughput screen identifies 5‐HT receptor as a modulator of AR and a therapeutic target for prostate cancer by Itsumi, Momoe, Shiota, Masaki, Sekino, Yohei, Ushijima, Miho, Kashiwagi, Eiji, Takeuchi, Ario, Inokuchi, Junichi, Kajioka, Shunichi, Uchiumi, Takeshi, Eto, Masatoshi

“…Background Eradication of persistent androgen receptor (AR) activity in castration‐resistant prostate cancer may be a promising strategy to overcome castration…”
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Validation of models predicting lymph node involvement probability in patients with prostate cancer by Blas, Leandro, Shiota, Masaki, Nagakawa, Shohei, Tsukahara, Shigehiro, Matsumoto, Takashi, Monji, Keisuke, Kashiwagi, Eiji, Takeuchi, Ario, Inokuchi, Junichi, Eto, Masatoshi

“…Objectives There are many models to predict lymph node involvement in patients with prostate cancer. We aimed to externally validate several models in a…”
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Prognostic significance of risk stratification in CHAARTED and LATITUDE studies among Japanese men with de novo metastatic prostate cancer by Shiota, Masaki, Namitome, Ryo, Kobayashi, Takeshi, Inokuchi, Junichi, Tatsugami, Katsunori, Eto, Masatoshi

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Immune‐related adverse events in urothelial cancer patients: Adjustment for immortal time bias by Otsuka, Hikari, Kita, Yuki, Ito, Katsuhiro, Sano, Takeshi, Inokuchi, Junichi, Tomida, Ryotaro, Takahashi, Atsushi, Matsumoto, Kazumasa, Kurahashi, Ryoma, Ozaki, Yu, Uegaki, Masayuki, Maruyama, Satoru, Mukai, Shoichiro, Tsutsumi, Masakazu, Kawahara, Takashi, Segawa, Takehiko, Kitamura, Hiroshi, Morita, Satoshi, Kobayashi, Takashi

“…To investigate the association between the onset, severity, and type of immune‐related adverse events (irAEs) and the efficacy of pembrolizumab in patients…”
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Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin by Shiota, Masaki, Yokomizo, Akira, Kashiwagi, Eiji, Tada, Yasuhiro, Inokuchi, Junichi, Tatsugami, Katsunori, Kuroiwa, Kentaro, Uchiumi, Takeshi, Seki, Narihito, Naito, Seiji

“…Many advanced cancers receive cisplatin‐based chemotherapy. However, cisplatin resistance is a major obstacle for cancer chemotherapy. Foxo3a is a member of…”
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Perioperative therapies for urological cancers by Inokuchi, Junichi, Yokomizo, Akira, Nishiyama, Naotaka, Kitamura, Hiroshi, Eto, Masatoshi, Nishiyama, Hiroyuki, Tomita, Yoshihiko

“…Abstract Although surgery with curative intent is critical for management of many localized cancers, multimodal therapy including neoadjuvant and adjuvant…”
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