Search Results - "INGALLS, Stephen T"

Selective and accurate C5 acylcarnitine quantitation by UHPLC–MS/MS: Distinguishing true isovaleric acidemia from pivalate derived interference by Minkler, Paul E., Stoll, Maria S.K., Ingalls, Stephen T., Hoppel, Charles L.

“…[Display omitted] •Four C5 acylcarnitines synthesized and characterized.•Isovalerylcarnitine distinguished from pivaloylcarnitine using UHPLC–MS/MS.•Excellent…”
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Quantitative acylcarnitine determination by UHPLC-MS/MS — Going beyond tandem MS acylcarnitine “profiles” by Minkler, Paul E., Stoll, Maria S.K., Ingalls, Stephen T., Kerner, Janos, Hoppel, Charles L.

“…Tandem MS “profiling” of acylcarnitines and amino acids was conceived as a first-tier screening method, and its application to expanded newborn screening has…”
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Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue by Minkler, Paul E., Kerner, Janos, Ingalls, Stephen T., Hoppel, Charles L.

“…A novel procedure for the quantitative isolation and purification of acyl-coenzyme A esters is presented. The procedure involves two steps: (1) tissue…”
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Quantification of Carnitine and Acylcarnitines in Biological Matrices by HPLC Electrospray Ionization- Mass Spectrometry by Minkler, Paul E, Stoll, Maria S. K, Ingalls, Stephen T, Yang, Shuming, Kerner, Janos, Hoppel, Charles L

“…Analysis of carnitine and acylcarnitines by tandem mass spectrometry (MS/MS) has limitations. First, preparation of butyl esters partially hydrolyzes…”
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Development of β-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase 1 Levels by Reinicke, Kathryn E, Bey, Erik A, Bentle, Melissa S, Pink, John J, Ingalls, Stephen T, Hoppel, Charles L, Misico, Rosana I, Arzac, Gisela M, Burton, Gerardo, Bornmann, William G, Sutton, Damon, Gao, Jinming, Boothman, David A

“…β-Lapachone, an o -naphthoquinone, induces a novel caspase- and p53-independent apoptotic pathway dependent on NAD(P)H:quinone oxidoreductase 1 (NQO1). NQO1…”
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Strategy for the Isolation, Derivatization, Chromatographic Separation, and Detection of Carnitine and Acylcarnitines by Minkler, Paul E, Ingalls, Stephen T, Hoppel, Charles L

“…A strategy for detection of carnitine and acylcarnitines is introduced. This versatile system has four components:  (1) isolation by protein…”
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Validated Method for the Quantification of Free and Total Carnitine, Butyrobetaine, and Acylcarnitines in Biological Samples by Minkler, Paul E, Stoll, Maria S. K, Ingalls, Stephen T, Kerner, Janos, Hoppel, Charles L

“…A validated quantitative method for the determination of free and total carnitine, butyrobetaine, and acylcarnitines is presented. The versatile method has…”
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A Phase I and Pharmacodynamic Study of Fludarabine, Carboplatin, and Topotecan in Patients With Relapsed, Refractory, or High-Risk Acute Leukemia by COOPER, Brenda W, VEAL, Gareth J, GOSKY, David, INGALLS, Stephen T, HOPPEL, Charles L, GERSON, Stanton L, RADIVOYEVITCH, Tomas, TILBY, Michael J, MEYERSON, Howard J, LAZARUS, Hillard M, KOC, Omer N, CREGER, Richard J, PEARSON, Graham, NOWELL, Geoff M

“…Purpose: A novel regimen designed to maximize antileukemia activity of carboplatin through inhibiting repair of platinum-DNA adducts was conducted in poor…”
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Correcting false positive medium-chain acyl-CoA dehydrogenase deficiency results from newborn screening; synthesis, purification, and standardization of branched-chain C8 acylcarnitines for use in their selective and accurate absolute quantitation by UHPLC–MS/MS by Minkler, Paul E., Stoll, Maria S.K., Ingalls, Stephen T., Hoppel, Charles L.

“…While selectively quantifying acylcarnitines in thousands of patient samples using UHPLC–MS/MS, we have occasionally observed unidentified branched-chain C8…”
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Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia by Kunos, Charles A, Radivoyevitch, Tomas, Ingalls, Stephen T, Hoppel, Charles L

“…The anticancer agent 3-aminopyridine-2-carboxaldehyde thiosemicarbazone is a ribonucleotide reductase inhibitor. It inactivates ribonucleotide reductase by…”
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Phase I Clinical and Pharmacokinetic Study of Rebeccamycin Analog NSC 655649 Given Daily for Five Consecutive Days by DOWLATI, Afshin, HOPPEL, Charles L, INGALLS, Stephen T, MAJKA, Susan, XIAOLIN LI, SEDRANSK, Nell, SPIRO, Timothy, GERSON, Stanton L, IVY, Percy, REMICK, Scot C

“…Rebeccamycin analog (NSC 655649) is active against a variety of both solid and nonsolid tumor cell lines. We performed a phase I trial to determine the…”
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Selective, Accurate, and Precise Quantitation of Glutarylcarnitine in Human Urine from a Patient with Glutaric Acidemia Type I by Minkler, Paul E, Stoll, Maria S K, Ingalls, Stephen T, Hoppel, Charles L

“…Although correctly used in expanded newborn screening programs to identify patients with possible diseases, flow-injection tandem mass spectrometry (MS/MS)…”
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Pharmacokinetics of O6-Benzylguanine (NSC637037) and Its Metabolite, 8-Oxo-O6-Benzylguanine by Tserng, Kou-Yi, Ingalls, Stephen T., Boczko, Erik M., Spiro, Timothy P., Li, Xiaolin, Majka, Susan, Gerson, Stanton L., Willson, James K. V., Hoppel, Charles L.

“…O6‐Benzylguanine and its metabolite, 8‐oxo‐O6‐benzylguanine, are equally potent inhibitors of the DNA repair enzyme, O6‐alkylguanine‐DNA alkyltransferase…”
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Preliminary clinical and pharmacologic investigation of photodynamic therapy with the silicon phthalocyanine photosensitizer pc 4 for primary or metastatic cutaneous cancers by Kinsella, Timothy James, Baron, Elma D, Colussi, Valdir C, Cooper, Kevin D, Hoppel, Charles L, Ingalls, Stephen T, Kenney, Malcolm E, Li, Xiaolin, Oleinick, Nancy L, Stevens, Seth R, Remick, Scot C

“…Photodynamic therapy (PDT) for cutaneous malignancies has been found to be an effective treatment with a range of photosensitizers. The phthalocyanine Pc 4 was…”
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A phase IB clinical and pharmacokinetic study of the angiogenesis inhibitor SU5416 and paclitaxel in recurrent or metastatic carcinoma of the head and neck by COONEY, Matthew M, TSERNG, Kou-Yi, IVY, Percy, HOPPEL, Charles L, REMICK, Scot, MAKAR, Vinit, MCPEAK, R. Jeff, INGALLS, Stephen T, DOWLATI, Afshin, OVERMOYER, Beth, MCCRAE, Keith, KSENICH, Pamela, LAVERTU, Pierre

“…SU5416 is a novel small organic molecule that non-competitively inhibits the phosphorylation of the VEGF tyrosine kinase receptor, Flk-1. This phase IB study…”
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Phase I clinical and pharmacokinetic study of oxaliplatin, irinotecan and capecitabine by Krishnamurthi, Smitha S, Brell, Joanna M, Hoppel, Charles L, Egorin, Merrill J, Weaver, Karen C, Li, Xiaolin, Ingalls, Stephen T, Zuhowski, Eleanor G, Schluchter, Mark D, Dowlati, Afshin, Cooney, Matthew M, Gibbons, Joseph, Overmoyer, Beth A, Ivy, S. Percy, Remick, Scot C

“…Purpose To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of the combination of weekly oxaliplatin x 4, weekly irinotecan x 4 and…”
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Quantification of Carnitine, Acetylcarnitine, and Total Carnitine in Tissues by High-Performance Liquid Chromatography: The Effect of Exercise on Carnitine Homeostasis in Man by Minkler, Paul E., Brass, Eric P., Hiatt, William R., Ingalls, Stephen T., Hoppel, Charles L.

“…A method for the quantitative determination of carnitine, acetylcarnitine, and total carnitine in tissue was developed for application to clinical research and…”
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A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia by Cooper, Brenda W, Donaher, Erin, Lazarus, Hillard M, Green, Sylvan B, Gosky, David M, Rosenthal, Nancy S, Berger, Sosamma J, Li, Xiaolin, Ingalls, Stephen T, Hoppel, Charles L, Gerson, Stanton L

“…We designed a pharmacokinetic and pharmacodynamic phase I study of sequential topotecan (2.55–6.3 mg/m 2) by 72 h infusion followed by five daily doses of…”
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Furosemide kinetics in patients with hepatic cirrhosis with ascites by Fuller, R, Hoppel, C, Ingalls, S T

“…Furosemide, 20 mg, was given intravenously as a bolus to seven patients with cirrhotic ascites and a 10-mg intravenous bolus dose was given to three normal…”
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Acylcarnitines: Distinguishing acylcarnitine isomeric forms by HPLC/ESI/MS by Minkler, Paul E., Yang, Shuming, Stoll, Maria S.K., Ingalls, Stephen T., Hoppel, Charles L.

“…Isomeric acylcarnitines are indistinguishable by tandem mass spectrometry. This methodological deficiency can be overcome by including a chromatographic…”
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