Effect of Polyacetylenes on the Neurite Outgrowth of Neuronal Culture Cells and Scopolamine-Induced Memory Impairment in Mice

Polyacetylenic alcohols and their linoleates isolated from Panax ginseng C.A. Meyer and Cirsium japonicum DC., of which the lipophilic extracts had been found to affect the neuritogenesis of cultured paraneurons, were demonstrated to have a significant neuritogenic effect on PC12h and Neuro2a cells....

Full description

Saved in:

Bibliographic Details
Published in:	Biological & pharmaceutical bulletin Vol. 24; no. 12; pp. 1434 - 1436
Main Authors:	YAMAZAKI, Matsumi, HIRAKURA, Kazuhiro, MIYAICHI, Yukinori, IMAKURA, Kimiaki, KITA, Mika, CHIBA, Kenzo, MOHRI, Tetsuro
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 01-12-2001 Maruzen Japan Science and Technology Agency
Subjects:	Acetylene - analogs & derivatives Acetylene - isolation & purification Acetylene - pharmacology Acetylene - therapeutic use Animals Biological and medical sciences General pharmacology Male Medical sciences Memory Disorders - chemically induced Memory Disorders - drug therapy memory improvement Mice Muscarinic Antagonists - toxicity neurite outgrowth Neurites - drug effects Neurites - physiology Neuro2a cell Neurons - cytology Neurons - drug effects Neurons - physiology Neuropharmacology Panax PC12 Cells PC12h cell Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots polyacetylene Polymers - isolation & purification Polymers - pharmacology Polymers - therapeutic use Polyynes Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Scopolamine - toxicity Memory disorder Intraperitoneal administration Cognitive disorder Neurite Psychotropic Central nervous system Compositae Panax ginseng Medicinal plant Dicotyledones Angiospermae Established cell line Araliaceae Pharmacognosy Rodentia In vitro Biological activity Acetylene polymer In vivo Vertebrata Mammalia Neuron Mouse Animal Nootropic agent Plant origin Spermatophyta Cirsium arvense Brain (vertebrata)
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Polyacetylenic alcohols and their linoleates isolated from Panax ginseng C.A. Meyer and Cirsium japonicum DC., of which the lipophilic extracts had been found to affect the neuritogenesis of cultured paraneurons, were demonstrated to have a significant neuritogenic effect on PC12h and Neuro2a cells. Panaxynol and the acetylenic triol in particular were highly efficient at concentrations ≥2 μM. Panaxynol (20 mg/kg/d, i.p., for 3 d) was confirmed to improve scopolamine-induced memory deficit in mice (Y-maze task). It is suggested that the promotion of neuritogenesis in cultured paraneurons by the addition of panaxynol is related its ability to improve memory deficits in animals.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.24.1434