Search Results - "ILJIN, Kristiina"

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression by HILVO, Mika, DENKERT, Carsten, BERG, Emilia, NYGREN, Heli, SYSI-AHO, Marko, GRIFFIN, Julian L, FIEHN, Oliver, LOIBL, Sibylle, RICHTER-EHRENSTEIN, Christiane, RADKE, Cornelia, HYÖTYLÄINEN, Tuulia, KALLIONIEMI, Olli, LEHTINEN, Laura, ILJIN, Kristiina, ORESIC, Matej, MÜLLE, Berit, BROCKRNÖLLE, Scarlet, SEPPÄNEN-LAAKSO, Tuulikki, BUDCZIES, Jan, BUCHET, Elmar, YETUKURI, Laxman, CASTILLO, Sandra

“…Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many cancers. However, the precise molecular composition of lipids…”
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FZD4 as a Mediator of ERG Oncogene―Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells by GUPTA, Santosh, ILJIN, Kristiina, SARA, Henri, MPINDI, John Patrick, MIRTTI, Tuomas, VAINIO, Paula, RANTALA, Juha, ALANEN, Kalle, NEES, Matthias, KALLIONIEMI, Olli

“…TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. Although ERG activation has…”
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Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells by Ketola, Kirsi, Vainio, Paula, Fey, Vidal, Kallioniemi, Olli, Iljin, Kristiina

“…Current treatment options for advanced and hormone refractory prostate cancer are limited and responses to commonly used androgen pathway inhibitors are often…”
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Function of ERBB4 is determined by alternative splicing by Veikkolainen, Ville, Vaparanta, Katri, Halkilahti, Kalle, Iljin, Kristiina, Sundvall, Maria, Elenius, Klaus

“…Alternative splicing is a central tool of evolution that significantly increases the size of transcriptomes and generates functional specification. Within the…”
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Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells by Ketola, Kirsi, Kallioniemi, Olli, Iljin, Kristiina

“…Current treatment options for castration- and treatment-resistant prostate cancer are limited and novel approaches are desperately needed. Our recent results…”
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High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth by IIJIN, Kristiina, KETOLA, Kirsi, VAINIO, Paula, HALONEN, Pasi, KOHONEN, Pekka, FEY, Vidal, GRAFSTRÖM, Roland C, PERÄLÄ, Merja, KALLIONIEMI, Olli

“…Purpose: To identify novel therapeutic opportunities for patients with prostate cancer, we applied high-throughput screening to systematically explore most…”
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High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion by Lehtinen, Laura, Ketola, Kirsi, Mäkelä, Rami, Mpindi, John-Patrick, Viitala, Miro, Kallioniemi, Olli, Iljin, Kristiina

“…Vimentin is an intermediate filament protein, with a key role in the epithelial to mesenchymal transition as well as cell invasion, and it is often upregulated…”
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Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues by Kilpinen, Sami, Autio, Reija, Ojala, Kalle, Iljin, Kristiina, Bucher, Elmar, Sara, Henri, Pisto, Tommi, Saarela, Matti, Skotheim, Rolf I, Björkman, Mari, Mpindi, John-Patrick, Haapa-Paananen, Saija, Vainio, Paula, Edgren, Henrik, Wolf, Maija, Astola, Jaakko, Nees, Matthias, Hautaniemi, Sampsa, Kallioniemi, Olli

“…Our knowledge on tissue- and disease-specific functions of human genes is rather limited and highly context-specific. Here, we have developed a method for the…”
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Arachidonic Acid Pathway Members PLA2G7 , HPGD , EPHX2 , and CYP4F8 Identified as Putative Novel Therapeutic Targets in Prostate Cancer by Vainio, Paula, Gupta, Santosh, Ketola, Kirsi, Mirtti, Tuomas, Mpindi, John-Patrick, Kohonen, Pekka, Fey, Vidal, Perälä, Merja, Smit, Frank, Verhaegh, Gerald, Schalken, Jack, Alanen, Kalle A, Kallioniemi, Olli, Iljin, Kristiina

“…The arachidonic acid and prostaglandin pathway has been implicated in prostate carcinogenesis, but comprehensive studies of the individual members in this key…”
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Robust Approach for Quantifying Glucocorticoid Binding to the Anti-Cortisol Fab Fragment via Native Mass Spectrometry by Eronen, Veikko, Iljin, Kristiina, Pääkkönen, Johan, Jänis, Janne, Rouvinen, Juha, Nevanen, Tarja K., Hakulinen, Nina

“…In the development of proteins, aptamers, and molecular imprints for diagnostic purposes, a major goal is to obtain a molecule with both a high binding…”
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High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer by Vainio, Paula, Mpindi, John-Patrick, Kohonen, Pekka, Fey, Vidal, Mirtti, Tuomas, Alanen, Kalle A, Perälä, Merja, Kallioniemi, Olli, Iljin, Kristiina

“…Prostate cancer is a heterogeneous group of diseases and there is a need for more efficient and targeted methods of treatment. In this study, the potential of…”
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c-Jun N-Terminal Kinase Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells by Björkblom, Benny, Padzik, Artur, Mohammad, Hasan, Westerlund, Nina, Komulainen, Emilia, Hollos, Patrik, Parviainen, Lotta, Papageorgiou, Anastassios C., Iljin, Kristiina, Kallioniemi, Olli, Kallajoki, Markku, Courtney, Michael J., Mågård, Mats, James, Peter, Coffey, Eleanor T.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker by Lehtinen, Laura, Vesterkvist, Pia, Roering, Pia, Korpela, Taina, Hattara, Liisa, Kaipio, Katja, Mpindi, John-Patrick, Hynninen, Johanna, Auranen, Annika, Davidson, Ben, Haglund, Caj, Iljin, Kristiina, Grenman, Seija, Siitari, Harri, Carpen, Olli

“…Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in…”
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FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion by Gardberg, Maria, Kaipio, Katja, Lehtinen, Laura, Mikkonen, Piia, Heuser, Vanina D, Talvinen, Kati, Iljin, Kristiina, Kampf, Caroline, Uhlen, Mathias, Grénman, Reidar, Koivisto, Mari, Carpén, Olli

“…Cancer cells can obtain their ability to invade and metastasise by undergoing epithelial-to-mesenchymal transition (EMT). Exploiting this mechanism of cellular…”
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Characterization of Leukocyte Formin FMNL1 Expression in Human Tissues by Gardberg, Maria, Heuser, Vanina D., Iljin, Kristiina, Kampf, Caroline, Uhlen, Mathias, Carpén, Olli

“…Formins are cytoskeleton regulating proteins characterized by a common FH2 structural domain. As key players in the assembly of actin filaments, formins direct…”
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Tie receptors: new modulators of angiogenic and lymphangiogenic responses by Alitalo, Kari, Jones, Nina, Iljin, Kristiina, Dumont, Daniel J

“…Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and…”
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Integration of Metabolomics and Expression of Glycerol-3-phosphate Acyltransferase (GPAM) in Breast CancerLink to Patient Survival, Hormone Receptor Status, and Metabolic Profiling by Brockmöller, Scarlet F, Bucher, Elmar, Müller, Berit M, Budczies, Jan, Hilvo, Mika, Griffin, Julian L, Orešič, Matej, Kallioniemi, Olli, Iljin, Kristiina, Loibl, Sibylle, Darb-Esfahani, Silvia, Sinn, Bruno V, Klauschen, Frederick, Prinzler, Judith, Bangemann, Nikola, Ismaeel, Fakher, Fiehn, Oliver, Dietel, Manfred, Denkert, Carsten

“…Changes in lipid metabolism are an important but not well-characterized hallmark of cancer. On the basis of our recent findings of lipidomic changes in breast…”
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Integrative Functional Genomics Analysis of Sustained Polyploidy Phenotypes in Breast Cancer Cells Identifies an Oncogenic Profile for GINS2 by Rantala, Juha K., Edgren, Henrik, Lehtinen, Laura, Wolf, Maija, Kleivi, Kristine, Vollan, Hans Kristian Moen, Aaltola, Anna-Riina, Laasola, Petra, Kilpinen, Sami, Saviranta, Petri, Iljin, Kristiina, Kallioniemi, Olli

“…Aneuploidy is among the most obvious differences between normal and cancer cells. However, mechanisms contributing to development and maintenance of aneuploid…”
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Systemic analysis of gene expression profiles identifies ErbB3 as a potential drug target in pediatric alveolar rhabdomyosarcoma by Nordberg, Janne, Mpindi, John Patrick, Iljin, Kristiina, Pulliainen, Arto Tapio, Kallajoki, Markku, Kallioniemi, Olli, Elenius, Klaus, Elenius, Varpu

“…Pediatric sarcomas, including rhabdomyosarcomas, Ewing's sarcoma, and osteosarcoma, are aggressive tumors with poor survival rates. To overcome problems…”
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GTI: a novel algorithm for identifying outlier gene expression profiles from integrated microarray datasets by Mpindi, John Patrick, Sara, Henri, Haapa-Paananen, Saija, Kilpinen, Sami, Pisto, Tommi, Bucher, Elmar, Ojala, Kalle, Iljin, Kristiina, Vainio, Paula, Björkman, Mari, Gupta, Santosh, Kohonen, Pekka, Nees, Matthias, Kallioniemi, Olli

“…Meta-analysis of gene expression microarray datasets presents significant challenges for statistical analysis. We developed and validated a new bioinformatic…”
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