Search Results - "IKUTANI, Masashi"

Heterogeneity of Group 2 Innate Lymphoid Cells Defines Their Pleiotropic Roles in Cancer, Obesity, and Cardiovascular Diseases by Ikutani, Masashi, Nakae, Susumu

“…Group 2 innate lymphoid cells (ILC2s) are typically known for their ability to respond rapidly to parasitic infections and play a pivotal role in the…”
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Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet‐induced adipose tissue inflammation by Honda, Hiroe, Nagai, Yoshinori, Matsunaga, Takayuki, Okamoto, Naoki, Watanabe, Yasuharu, Tsuneyama, Koichi, Hayashi, Hiroaki, Fujii, Isao, Ikutani, Masashi, Hirai, Yoshikatsu, Muraguchi, Atsushi, Takatsu, Kiyoshi

“…Isoliquiritigenin, a component of Glycyrrhiza uralensis, is a potent inhibitor of the NLRP3 inflammasome, and suppresses diet‐induced obesity, adipose tissue…”
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Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice by FUJISAKA, Shiho, USUI, Isao, KOBAYASHI, Masashi, TOBE, Kazuyuki, BUKHARI, Agussalim, IKUTANI, Masashi, OYA, Takeshi, KANATANI, Yukiko, TSUNEYAMA, Koichi, NAGAI, Yoshinori, TAKATSU, Kiyoshi, URAKAZE, Masaharu

“…Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice Shiho Fujisaka 1 , Isao Usui 1 , Agussalim Bukhari 1 , Masashi…”
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CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors by Nawaz, Allah, Aminuddin, Aminuddin, Kado, Tomonobu, Takikawa, Akiko, Yamamoto, Seiji, Tsuneyama, Koichi, Igarashi, Yoshiko, Ikutani, Masashi, Nishida, Yasuhiro, Nagai, Yoshinori, Takatsu, Kiyoshi, Imura, Johji, Sasahara, Masakiyo, Okazaki, Yukiko, Ueki, Kohjiro, Okamura, Tadashi, Tokuyama, Kumpei, Ando, Akira, Matsumoto, Michihiro, Mori, Hisashi, Nakagawa, Takashi, Kobayashi, Norihiko, Saeki, Kumiko, Usui, Isao, Fujisaka, Shiho, Tobe, Kazuyuki

“…Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting…”
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Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s by Saito, Kyoko, Orimo, Keisuke, Kubo, Terufumi, Tamari, Masato, Yamada, Ayako, Motomura, Kenichiro, Sugiyama, Hiroki, Matsuoka, Ryo, Nagano, Naoko, Hayashi, Yuka, Arae, Ken, Hara, Mariko, Ikutani, Masashi, Fukuie, Tatsuki, Sudo, Katsuko, Matsuda, Akio, Ohya, Yukihiro, Fujieda, Shigeharu, Saito, Hirohisa, Nakae, Susumu, Matsumoto, Kenji, Akdis, Cezmi A., Morita, Hideaki

“…Introduction Epidemiological studies demonstrated that cleaning work and frequent use of cleaning products are risk factors for asthma. Laundry detergents have…”
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Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes by Yamamoto, Seiji, Niida, Shumpei, Azuma, Erika, Yanagibashi, Tsutomu, Muramatsu, Masashi, Huang, Ting Ting, Sagara, Hiroshi, Higaki, Sayuri, Ikutani, Masashi, Nagai, Yoshinori, Takatsu, Kiyoshi, Miyazaki, Kenji, Hamashima, Takeru, Mori, Hisashi, Matsuda, Naoyuki, Ishii, Yoko, Sasahara, Masakiyo

“…Emerging lines of evidence have shown that extracellular vesicles (EVs) mediate cell-to-cell communication by exporting encapsulated materials, such as…”
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Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin by Arae, Ken, Ikutani, Masashi, Horiguchi, Kotaro, Yamaguchi, Sachiko, Okada, Youji, Sugiyama, Hiroki, Orimo, Keisuke, Morita, Hideaki, Suto, Hajime, Okumura, Ko, Taguchi, Haruhiko, Matsumoto, Kenji, Saito, Hirohisa, Sudo, Katsuko, Nakae, Susumu

“…Exposure to various antigens derived from house dust mites (HDM) is considered to be a risk factor for development of certain allergic diseases such as atopic…”
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IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells by Numata, Takafumi, Ikutani, Masashi, Arae, Ken, Ohno, Tatsukuni, Okada, Koki, Yoshimoto, Takayuki, Sudo, Katsuko, Suto, Hajime, Okumura, Ko, Saito, Hirohisa, Harada, Kazutoshi, Nakae, Susumu

“…Mast cells (MCs) are tissue-resident cells of hematopoietic origin that play an important role in host’s defense mechanism against nematodes. However,…”
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A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS by Yamamoto, Seiji, Muramatsu, Masashi, Azuma, Erika, Ikutani, Masashi, Nagai, Yoshinori, Sagara, Hiroshi, Koo, Bon-Nyeo, Kita, Satomi, O’Donnell, Erin, Osawa, Tsuyoshi, Takahashi, Hiroyuki, Takano, Ken-ichi, Dohmoto, Mitsuko, Sugimori, Michiya, Usui, Isao, Watanabe, Yasuhide, Hatakeyama, Noboru, Iwamoto, Takahiro, Komuro, Issei, Takatsu, Kiyoshi, Tobe, Kazuyuki, Niida, Shumpei, Matsuda, Naoyuki, Shibuya, Masabumi, Sasahara, Masakiyo

“…Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the…”
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Betulin Attenuates TGF-β1- and PGE2-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice by Ogasawara, Masaru, Yamasaki-Yashiki, Shino, Hamada, Masahiro, Yamaguchi-Miyamoto, Tomomi, Kawasuji, Toru, Honda, Hiroe, Yanagibashi, Tsutomu, Ikutani, Masashi, Watanabe, Yasuharu, Fujimoto, Ryota, Matsunaga, Takayuki, Nakajima, Noriyuki, Nagai, Yoshinori, Takatsu, Kiyoshi

“…Transforming growth factor (TGF)-β1 and prostaglandin E2 (PGE2) are humoral factors critically involved in the induction of immunosuppression in the…”
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Cyclosporin A indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lung inflammation by Kudo, Fujimi, Ikutani, Masashi, Iseki, Masanori, Takaki, Satoshi

“…•Activation and maintenance of ILC2s were inhibited by CsA in lung inflammation.•CsA did not directly suppress IL-5 expression by activated ILC2s in…”
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Elimination of eosinophils using anti-IL-5 receptor alpha antibodies effectively suppresses IL-33-mediated pulmonary arterial hypertrophy by Ikutani, Masashi, Ogawa, Shinya, Yanagibashi, Tsutomu, Nagai, Terumi, Okada, Kazuki, Furuichi, Yoko, Takatsu, Kiyoshi

“…Interleukin (IL)-5 is a critical regulator of eosinophils and a therapeutic target for asthma. The administration of anti-IL-5 or anti-IL-5 receptor (IL-5R)…”
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Direct platelet adhesion potentiates group 2 innate lymphoid cell functions by Orimo, Keisuke, Tamari, Masato, Takeda, Tomohiro, Kubo, Terufumi, Rückert, Beate, Motomura, Kenichiro, Sugiyama, Hiroki, Yamada, Ayako, Saito, Kyoko, Arae, Ken, Kuriyama, Motohiro, Hara, Mariko, Soyka, Michael B., Ikutani, Masashi, Yamaguchi, Sota, Morimoto, Noriko, Nakabayashi, Kazuhiko, Hata, Kenichiro, Matsuda, Akio, Akdis, Cezmi A., Sudo, Katsuko, Saito, Hirohisa, Nakae, Susumu, Tamaoki, Jun, Tagaya, Etsuko, Matsumoto, Kenji, Morita, Hideaki

“…Background Platelets are thought to be involved in the pathophysiology of asthma, presumably through direct adhesion to inflammatory cells, including group 2…”
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Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice by Fujisaka, Shiho, Usui, Isao, Kanatani, Yukiko, Ikutani, Masashi, Takasaki, Ichiro, Tsuneyama, Koichi, Tabuchi, Yoshiaki, Bukhari, Agussalim, Yamazaki, Yu, Suzuki, Hikari, Senda, Satoko, Aminuddin, Aminuddin, Nagai, Yoshinori, Takatsu, Kiyoshi, Kobayashi, Masashi, Tobe, Kazuyuki

“…Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization from an inflammatory M1 state to an antiinflammatry M2 state in…”
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The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity by Kim, Hyuk Soon, Lee, Min Bum, Lee, Dajeong, Min, Keun Young, Koo, Jimo, Kim, Hyun Woo, Park, Young Hwan, Kim, Su Jeong, Ikutani, Masashi, Takaki, Satoshi, Kim, Young Mi, Choi, Wahn Soo

“…The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)-producing…”
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Interleukin-5 plays a key role in mouse strain- dependent susceptibility to contact hypersensitivity through its effects on initiator B cells by Itakura, Atsuko, Ikutani, Masashi, Takatsu, Kiyoshi, Kikuchi, Yuji

“…Elicitation of contact hypersensitivity requires antigen-specific immunoglobulin M (IgM) antibodies that trigger recruitment of effector T cells to the local…”
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Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy by Ikutani, Masashi, Tsuneyama, Koichi, Kawaguchi, Makoto, Fukuoka, Junya, Kudo, Fujimi, Nakae, Susumu, Arita, Makoto, Nagai, Yoshinori, Takaki, Satoshi, Takatsu, Kiyoshi

“…IL-33 is one of the critical cytokines that activates group 2 innate lymphoid cells (ILC2s) and mediates allergic reactions. Accumulating evidence suggests…”
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The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells by Nagai, Yoshinori, Yanagibashi, Tsutomu, Watanabe, Yasuharu, Ikutani, Masashi, Kariyone, Ai, Ohta, Shoichiro, Hirai, Yoshikatsu, Kimoto, Masao, Miyake, Kensuke, Takatsu, Kiyoshi

“…Marginal zone (MZ) B cells mount rapid T-cell-independent (T-I) immune responses against microbial components such as LPS. While Toll-like receptor 4 (TLR4) is…”
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Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia by Takikawa, Akiko, Usui, Isao, Fujisaka, Shiho, Ikutani, Masashi, Senda, Satoko, Hattori, Shinpei, Tsuneyama, Koichi, Koshimizu, Yukiko, Inoue, Ran, Tanaka-Hayashi, Ayumi, Nakagawa, Takashi, Nagai, Yoshinori, Takatsu, Kiyoshi, Sasaoka, Toshiyasu, Mori, Hisashi, Tobe, Kazuyuki

“…Chronic inflammation is a pathophysiology of insulin resistance in metabolic diseases, such as obesity and type 2 diabetes. Adipose tissue macrophages (ATMs)…”
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Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells by Itakura, Atsuko, Kikuchi, Yuji, Kouro, Taku, Ikutani, Masashi, Takaki, Satoshi, Askenase, Philip W, Takatsu, Kiyoshi

“…Elicitation of contact sensitivity (CS) depends on B-1-cell-derived antigen-specific immunoglobulin M (IgM) antibodies that recruit CS effector T cells into…”
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