Search Results - "IKUTA, KOICHI"

Control of immunity by glucocorticoids in health and disease by Shimba, Akihiro, Ikuta, Koichi

“…Animals receive environmental stimuli from neural signals in order to produce hormones that control immune responses. Glucocorticoids (GCs) are a group of…”
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Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive Immunity by Shimba, Akihiro, Ikuta, Koichi

“…Animals have evolved circadian rhythms to adapt to the 24-h day-night cycle. Circadian rhythms are controlled by molecular clocks in the brain and periphery,…”
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Immune-enhancing effects of glucocorticoids in response to day–night cycles and stress by Shimba, Akihiro, Ikuta, Koichi

“…Abstract Environmental cues such as the day–night cycle or stressors trigger the production of glucocorticoids (GCs) by the adrenal cortex. GCs are well known…”
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Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress by Shimba, Akihiro, Ejima, Aki, Ikuta, Koichi

“…Glucocorticoids (GCs) are a class of steroid hormones secreted from the adrenal cortex. Their production is controlled by circadian rhythm and stress, the…”
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Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues by Cui, Guangwei, Abe, Shinya, Kato, Ryoma, Ikuta, Koichi

“…Invariant natural killer T (iNKT) cells are a distinct subpopulation of innate-like T lymphocytes. They are characterized by semi-invariant T cell receptors…”
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Editorial: Circadian Control of Immunity by Ikuta, Koichi, Scheiermann, Christoph

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High-throughput identification and quantification of single bacterial cells in the microbiota by Jin, Jianshi, Yamamoto, Reiko, Takeuchi, Tadashi, Cui, Guangwei, Miyauchi, Eiji, Hojo, Nozomi, Ikuta, Koichi, Ohno, Hiroshi, Shiroguchi, Katsuyuki

“…The bacterial microbiota works as a community that consists of many individual organisms, i.e., cells. To fully understand the function of bacterial…”
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Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation by Cordeiro Gomes, Ana, Hara, Takahiro, Lim, Vivian Y., Herndler-Brandstetter, Dietmar, Nevius, Erin, Sugiyama, Tatsuki, Tani-ichi, Shizue, Schlenner, Susan, Richie, Ellen, Rodewald, Hans-Reimer, Flavell, Richard A., Nagasawa, Takashi, Ikuta, Koichi, Pereira, João Pedro

“…Hematopoietic stem cells (HSCs) self-renew in bone marrow niches formed by mesenchymal progenitors and endothelial cells expressing the chemokine CXCL12, but…”
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Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene by Mukohira, Hisa, Hara, Takahiro, Abe, Shinya, Tani-Ichi, Shizue, Sehara-Fujisawa, Atsuko, Nagasawa, Takashi, Tobe, Kazuyuki, Ikuta, Koichi

“…Stromal cells in bone marrow (BM) constitute a specific microenvironment supporting the development and maintenance of hematopoietic cells. Adiponectin is a…”
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Control of Immunity and Allergy by Steroid Hormones by Ikuta, Koichi, Ejima, Aki, Abe, Shinya, Shimba, Akihiro

“…Steroid hormones, especially glucocorticoids, androgens, and estrogens, have profound influence on immunity. Recent studies using cell-type specific steroid…”
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Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells by Asahi, Takuma, Abe, Shinya, Tajika, Yuya, Rodewald, Hans-Reimer, Sexl, Veronika, Takeshima, Hiroshi, Ikuta, Koichi

“…Abstract Group 1 innate lymphoid cells (G1-ILCs) are innate immune effectors critical for the response to intracellular pathogens and tumors. G1-ILCs comprise…”
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Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung by Okamoto Yoshida, Yuko, Umemura, Masayuki, Yahagi, Ayano, O'Brien, Rebecca L, Ikuta, Koichi, Kishihara, Kenji, Hara, Hiromitsu, Nakae, Susumu, Iwakura, Yoichiro, Matsuzaki, Goro

“…Granulomas play an essential role in the sequestration and killing of mycobacteria in the lung; however, the mechanisms of their development and maturation are…”
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Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies by Kansler, Emily R., Dadi, Saïda, Krishna, Chirag, Nixon, Briana G., Stamatiades, Efstathios G., Liu, Ming, Kuo, Fengshen, Zhang, Jing, Zhang, Xian, Capistrano, Kristelle, Blum, Kyle A., Weiss, Kate, Kedl, Ross M., Cui, Guangwei, Ikuta, Koichi, Chan, Timothy A., Leslie, Christina S., Hakimi, A. Ari, Li, Ming O.

“…Malignancy can be suppressed by the immune system. However, the classes of immunosurveillance responses and their mode of tumor sensing remain incompletely…”
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Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo by Cui, Guangwei, Hara, Takahiro, Simmons, Szandor, Wagatsuma, Keisuke, Abe, Akifumi, Miyachi, Hitoshi, Kitano, Satsuki, Ishii, Masaru, Tani-ichi, Shizue, Ikuta, Koichi

“…IL-15 is a cytokine critical for development, maintenance, and response of T cells, natural killer (NK) cells, NK T cells, and dendritic cells. However, the…”
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Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice by Inokawa, Hitoshi, Umemura, Yasuhiro, Shimba, Akihiro, Kawakami, Eiryo, Koike, Nobuya, Tsuchiya, Yoshiki, Ohashi, Munehiro, Minami, Yoichi, Cui, Guangwei, Asahi, Takuma, Ono, Ryutaro, Sasawaki, Yuh, Konishi, Eiichi, Yoo, Seung-Hee, Chen, Zheng, Teramukai, Satoshi, Ikuta, Koichi, Yagita, Kazuhiro

“…Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting circadian…”
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Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells by Ejima, Aki, Abe, Shinya, Shimba, Akihiro, Sato, Susumu, Uehata, Takuya, Tani-ichi, Shizue, Munakata, Satoru, Cui, Guangwei, Takeuchi, Osamu, Hirai, Toyohiro, Kato, Shigeaki, Ikuta, Koichi

“…Abstract Asthma is more common in females than males after adolescence. However, the mechanism of the sex bias in the prevalence of asthma remains unknown. To…”
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Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice by Hara, Takahiro, Shitara, Soichiro, Imai, Kumiko, Miyachi, Hitoshi, Kitano, Satsuki, Yao, Hisayuki, Tani-ichi, Shizue, Ikuta, Koichi

“…IL-7 is a cytokine crucial for development and maintenance of lymphocytes and other hematopoietic cells. However, how IL-7-expressing cells are distributed in…”
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Tissue maintenance of CMV-specific inflationary memory T cells by IL-15 by Baumann, Nicolas S, Torti, Nicole, Welten, Suzanne P M, Barnstorf, Isabel, Borsa, Mariana, Pallmer, Katharina, Oduro, Jennifer D, Cicin-Sain, Luka, Ikuta, Koichi, Ludewig, Burkhard, Oxenius, Annette

“…Cytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary, that is characterised by accumulation and maintenance of high…”
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Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches by Asahi, Takuma, Abe, Shinya, Cui, Guangwei, Shimba, Akihiro, Nabekura, Tsukasa, Miyachi, Hitoshi, Kitano, Satsuki, Ohira, Keizo, Dijkstra, Johannes M, Miyazaki, Masaki, Shibuya, Akira, Ohno, Hiroshi, Ikuta, Koichi

“…Group 1 innate lymphoid cells (G1-ILCs), including circulating natural killer (NK) cells and tissue-resident type 1 ILCs (ILC1s), are innate immune sentinels…”
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Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations by Tani-ichi, Shizue, Shimba, Akihiro, Wagatsuma, Keisuke, Miyachi, Hitoshi, Kitano, Satsuki, Imai, Kumiko, Hara, Takahiro, Ikuta, Koichi

“…Interleukin (IL)-7 is a cytokine essential for T lymphocyte development and homeostasis. However, little is known about the roles of IL-7 receptor α-chain…”
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