Search Results - "IKUMA, M."

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer by Iwaizumi, M, Shinmura, K, Mori, H, Yamada, H, Suzuki, M, Kitayama, Y, Igarashi, H, Nakamura, T, Suzuki, H, Watanabe, Y, Hishida, A, Ikuma, M, Sugimura, H

“…Chromosomal instability (CIN) is recognised as a hallmark of cancer and is caused by a spindle assembly checkpoint disorder or chromosome mis-segregation…”
Get more information

Factors that contribute to faecal cyclooxygenase-2 mRNA expression in subjects with colorectal cancer by Hamaya, Y, Yoshida, K, Takai, T, Ikuma, M, Hishida, A, Kanaoka, S

“…Background: We previously reported that a faecal cyclooxygenase-2 (COX-2) mRNA assay was useful for identifying colorectal cancer (CRC). This study sought to…”
Get full text

[13C]‐pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole by FURUTA, T., KODAIRA, C., NISHINO, M., YAMADE, M., SUGIMOTO, M., IKUMA, M., HISHIDA, A., WATANABE, H., UMEMURA, K.

“…Summary Background  13CO2 is produced on metabolism of 13C‐labelled‐pantoprazole ([13C]‐pantoprazole) by CYP2C19. Aim  To investigate whether the…”
Get full text

Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels by Askwith, C C, Cheng, C, Ikuma, M, Benson, C, Price, M P, Welsh, M J

“…Acidosis is associated with inflammation and ischemia and activates cation channels in sensory neurons. Inflammation also induces expression of FMRFamidelike…”
Get full text

Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP2C19 genotypes and 23s rRNA genotypes of H. pylori by FURUTA, T, SUGIMOTO, M, IKUMA, M, WATANABE, H, UMEMURA, K, ISHIZAKI, T, HISHIDA, A, SHIRAI, N, MATSUSHITA, F, NAKAJIMA, H, KUMAGAI, J, SENOO, K, KODAIRA, C, NISHINO, M, YAMADE, M

Get full text

Influences of proinflammatory and anti‐inflammatory cytokine polymorphisms on eradication rates of clarithromycin‐sensitive strains of Helicobacter pylori by triple therapy by Sugimoto, Mitsushige, Furuta, Takahisa, Shirai, Naohito, Ikuma, Mutsuhiro, Hishida, Akira, Ishizaki, Takashi

“…Backgrounds and Aims Polymorphisms of proinflammatory cytokines, such as interleukin (IL) 1β and tumor necrosis factor (TNF) α, are associated with individual…”
Get full text

Clinical course of fetal congenital atrioventricular block in the Japanese population: a multicentre experience by Maeno, Y, Himeno, W, Saito, A, Hiraishi, S, Hirose, O, Ikuma, M, Inamura, N, Kawataki, M, Mizukami, A, Ota, M, Shiraishi, H, Satomi, G, Kato, H

“…Objectives: To elucidate the prenatal and postnatal course of fetal congenital atrioventricular block (CAVB) during the past decade in the Japanese population…”
Get full text

Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status by Sugimoto, Mitsushige, Furuta, Takahisa, Shirai, Naohito, Ikuma, Mutsuhiro, Hishida, Akira, Ishizaki, Takashi

“…Backgrounds and Aims Faster and stronger acid inhibition is required for the treatment of hemorrhage from peptic ulcers. We compared the effects of intravenous…”
Get full text

Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori by FURUTA, T., SUGIMOTO, M., SHIRAI, N., MATSUSHITA, F., NAKAJIMA, H., KUMAGAI, J., SENOO, K., KODAIRA, C., NISHINO, M., YAMADE, M., IKUMA, M., WATANABE, H., UMEMURA, K., ISHIZAKI, T., HISHIDA, A.

“…Summary Background Polymorphism in MDR1 is associated with variation in the plasma level of a proton pump inhibitor. Aim To investigate whether MDR1…”
Get full text

Role of apical H-K exchange and basolateral K channel in the regulation of intracellular pH in rat distal colon crypt cells by Ikuma, M, Binder, H J, Geibel, J

“…An apical membrane ouabain-sensitive H-K exchange and a barium-sensitive basolateral membrane potassium channel are present in colonic crypt cells and may play…”
Get full text

Maintenance of the undersea section of the Seikan Tunnel by Ikuma, Michitsugu

“…This paper introduces the results of measurements made over a period of 14 years after the Seikan Tunnel was opened for service. Because this tunnel is a very…”
Get full text

Effects of Aging on the Regulation of Intracellular pH in the Rat Jejunum by Ikuma, Mutsuhiro, Hanai, Hiroyuki, Kaneko, Eizo, Hayashi, Hisayoshi, Hoshi, Takeshi

“…Jejunal villus cells from young-adult (6 months) and senescent (24 months) male Wistar rats were studied to evaluate the effect of aging on intracellular pH…”
Get full text

Normal Gating of CFTR Requires ATP Binding to Both Nucleotide-Binding Domains and Hydrolysis at the Second Nucleotide-Binding Domain by Berger, Allan L., Ikuma, Mutsuhiro, Welsh, Michael J.

“…ATP interacts with the two nucleotide-binding domains (NBDs) of CFTR to control gating. However, it is unclear whether gating involves ATP binding alone, or…”
Get full text

Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese by Sugimoto, Mitsushige, Furuta, Takahisa, Shirai, Naohito, Kodaira, Chise, Nishino, Masafumi, Ikuma, Mutsuhiro, Sugimura, Haruhiko, Hishida, Akira

“…Backgrounds and aims: The renin–angiotensin (RA) system including angiotensinogen (AGT), angiotensin I and angiotensin II influences the regulation of cell…”
Get full text

Regulation of CFTR Cl-Channel Gating by ATP Binding and Hydrolysis by Ikuma, Mutsuhiro, Welsh, Michael J.

“…Opening and closing of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel is regulated by the interaction of ATP with its two…”
Get full text

Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon by Ikuma, Mutsuhiro, Geibel, John, Binder, Henry J, Rajendran, Vazhaikkurichi M

“…Sodium-independent Cl movement (i.e., Cl-anion exchange) has not previously been identified in the basolateral membranes of rat colonic epithelial cells. The…”
Get more information

Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon by Ikuma, M, Kashgarian, M, Binder, H J, Rajendran, V M

“…Dietary sodium depletion has multiple diverse effects on ion transport in the rat colon, including both the induction and inhibition of electroneutral NaCl…”
Get full text

Mutations That Change the Position of the Putative γ-Phosphate Linker in the Nucleotide Binding Domains of CFTR Alter Channel Gating by Berger, Allan L., Ikuma, Mutsuhiro, Hunt, John F., Thomas, Philip J., Welsh, Michael J.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel is an ATP-binding cassette transporter that contains conserved nucleotide-binding…”
Get full text

Crosstalk between apical H, K-ATPase and basolateral K channel regulates intracellular (pHi) in rat distal colon by Ikuma, M., Binder, H.J., Geibel, J.P.

Get full text

Tissue-specific, differential and pretranslational regulation of Na−H exchange isoforms by aldosterone in rat colon by Binder, H.J., Ikuma, M., Rajendran, V.M.

Get full text