Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery

Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery

The efficacy of antibiotic prophylaxis in cardiac surgery was compared between 97 patients receiving a single 2 g dosage of ceftriaxone and 103 receiving 500 mg of vancomycin i.v. every 6 h for 48 h. The overall infection rate was 13.4% in the ceftriaxone and 10.7% in the vancomycin group. Four (4%)...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy Vol. 44; no. 2; pp. 287 - 290
Main Authors: SALMINEN, U.-S, VILJANEN, T. U. T, VALTONEN, V. V, IKONEN, T. E. H, SAHLMAN, A. E, HARJULA, A. L. J
Format: Journal Article
Language:English
Published: Oxford Oxford University Press 01-08-1999
Oxford Publishing Limited (England)
Subjects:
Aged
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotic Prophylaxis
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections - prevention & control
Biological and medical sciences
Ceftriaxone - therapeutic use
Cephalosporins - therapeutic use
Coronary Artery Bypass
Female
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prospective Studies
Surgical Wound Infection - prevention & control
Vancomycin - therapeutic use
Human
Intravenous administration
Peptides
Treatment efficiency
β-Lactams
Single dose
Cardiovascular disease
Ceftriaxone
Vancomycin
Infection
Prevention
Antibiotic
Chemotherapy
Cephalosporin derivatives
Randomization
Treatment
Glycopeptide
Surgery
Bacteriosis
Antibacterial agent
Comparative study
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The efficacy of antibiotic prophylaxis in cardiac surgery was compared between 97 patients receiving a single 2 g dosage of ceftriaxone and 103 receiving 500 mg of vancomycin i.v. every 6 h for 48 h. The overall infection rate was 13.4% in the ceftriaxone and 10.7% in the vancomycin group. Four (4%) wound infections, including one mediastinitis, occurred in the ceftriaxone group and five (5%) in the vancomycin group, with no statistically significant difference. The findings of this study support the adequacy of a simple single dose of ceftriaxone prophylaxis in cardiac surgery, at least in hospitals with low incidence of vancomycin-resistant staphylococcal infections.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/44.2.287