Search Results - "IKEMURA, Toshihide"

Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge by KANEHIRO, Arihiko, IKEMURA, Toshihide, MÄKELÄ, Mika J, LAHN, Michael, JOETHAM, Anthony, DAKHAMA, Azzeddine, GELFAND, Erwin W

“…We compared for the first time the therapeutic potential of a specific phosphodiesterase 4 (PDE4) inhibitor, rolipram, with anti-VLA-4 and anti-IL-5 in a model…”
Get full text

Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2 by Mimura, Hideki, Ikemura, Toshihide, Kotera, Osamu, Sawada, Masatsugu, Tashiro, Satoshi, Fuse, Eiichi, Ueno, Kimihisa, Manabe, Haruhiko, Ohshima, Etsuo, Karasawa, Akira, Miyaji, Hiromasa

“…Prostaglandin (PG) D2, a major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is known to induce activation and chemotaxis in…”
Get more information

Critical Roles for Interleukin-4 and Interleukin-5 during Respiratory Syncytial Virus Infection in the Development of Airway Hyperresponsiveness after Airway Sensitization by SCHWARZE, JURGEN, CIESLEWICZ, GRZEGORZ, JOETHAM, ANTHONY, IKEMURA, TOSHIHIDE, MAKELA, MIKA J, DAKHAMA, AZZEDDINE, SHULTZ, LEONARD D, LAMERS, MARINUS C, GELFAND, ERWIN W

“…In mice, respiratory syncytial virus (RSV) infection can enhance the consequences of allergic airway sensitization, resulting in lung eosinophilia and the…”
Get full text

Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice by KANEHIRO, Arihiko, TAKEDA, Katsuyuki, JOETHAM, Anthony, TOMKINSON, Adrian, IKEMURA, Toshihide, IRVIN, Charles G, GELFAND, Erwin W

“…The development of airway hyperresponsiveness (AHR) is correlated with the infiltration into the lungs of activated eosinophils and T lymphocytes. In large…”
Get full text

Type 4 phosphodiesterase inhibitors attenuate respiratory syncytial virus-induced airway hyper-responsiveness and lung eosinophilia by Ikemura, T, Schwarze, J, Makela, M, Kanehiro, A, Joetham, A, Ohmori, K, Gelfand, E W

“…Viral respiratory infections are considered one of the triggers of exacerbations of asthma. In a model of virus-induced airway hyper-responsiveness (AHR), mice…”
Get more information

KW-4679, an antiallergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils by Ikemura, T, Manabe, H, Sasaki, Y, Ishii, H, Onuma, K, Miki, I, Kase, H, Sato, S, Kitamura, S, Ohmori, K

“…The effects of (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz [b.e.]oxepin-2-acetic acid monohydrochloride (KW-4679), an orally active antiallergic…”
Get more information

KW‐4679‐induced inhibition of tachykininergic contraction in the guinea‐pig bronchi by prejunctional inhibition of peripheral sensory nerves by Ikemura, Toshihide, Okarmura, Kyoko, Sasaki, Yasuo, Ishi, Hidee, Ohmori, Kenji

“…1 Sensory mechanisms play an important role in the vagal regulation of tracheobronchial smooth muscle tone. We examined the effect of KW‐4679, an anti‐allergic…”
Get full text

Effects of KW-4679, a new orally active antiallergic drug, on antigen-induced bronchial hyperresponsiveness, airway inflammation and immediate and late asthmatic responses in guinea pigs by Ohmori, K, Ishii, H, Sasaki, Y, Ikemura, T, Manabe, H, Kitamura, S

“…We investigated the effects of KW-4679, an antiallergic drug, on the development of bronchial hyperresponsiveness, airway inflammation and early and late…”
Get more information

CD8 T Cells Are Essential in the Development of Respiratory Syncytial Virus-Induced Lung Eosinophilia and Airway Hyperresponsiveness by Schwarze, Jurgen, Cieslewicz, Grzegorz, Joetham, Anthony, Ikemura, Toshihide, Hamelmann, Eckard, Gelfand, Erwin W

“…Viral respiratory infections can cause bronchial hyperresponsiveness and exacerbate asthma. In mice, respiratory syncytial virus (RSV) infection results in…”
Get full text

Involvement of Neuropeptides in the Allergic Nasal Obstruction in Guinea Pigs by Kaise, Toshihiko, Akamatsu, Yukino, Ikemura, Toshihide, Ohmori, Kenji, Ishii, Akio, Karasawa, Akira

“…The purposes of the present study were i) to determine whether neuropeptides induce the nasal obstruction in guinea pigs, and ii) to examine the possible…”
Get full text

Pharmacological studies on KW-4679, an antiallergic drug. (1): Inhibitory effect on passive cutaneous anaphylaxis (PCA) and experimental asthma in rats and guinea pigs by Ishii, H, Sasaki, Y, Ikemura, T, Kitamura, S, Ohmori, K

“…The present experiment was carried out to elucidate the antiallergic properties of KW-4679. Oral administration of KW-4679 showed a dose-dependent inhibition…”
Get more information

Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness by Mäkelä, Mika J, Tripp, Ralph, Dakhama, Azzeddine, Park, Jun-Won, Ikemura, Toshihide, Joetham, Anthony, Waris, Matti, Anderson, Larry J, Gelfand, Erwin W

“…Respiratory syncytial virus (RSV) bronchiolitis in early life can lead to changes in airway function, but there are likely additional predisposing factors,…”
Get full text

Effect of KW-4679, a novel antiallergic drug, on platelet-activating factor (PAF)-induced bronchoconstriction, airway hyperresponsiveness and pulmonary cell accumulation in guinea pigs by Sasaki, Y, Ikemura, T, Ishii, H, Kitamura, S, Ohmori, K

“…We assessed the effects of KW-4679 on bronchoconstriction, airway hyperresponsiveness and infiltration of inflammatory cells into the bronchoalveolar lavage…”
Get more information

Effects of olopatadine hydrochloride (KW-4679), an antiallergic drug, on lipid mediators release from rat peritoneal mast cells and human neutrophils by Miyake, Kiyomi, Ikemura, Toshihide, Ikeda, Yoshimi, Ohmori, Kenji

“…Thromboxane (TX) A_2 and prostaglandin (PC) D_2 are important mediators in allergic diseases. Olopatadine hydrochloride (KW-4679) has been shown to be useful…”
Get full text

Involvement of Neuropeptides in the Allergic Nasal Obstruction in Guinea Pigs by Toshihiko Kaise, Yukino Akamatsu, Toshihide Ikemura, Kenji Ohmori, Akio Ishii, Akira Karasawa

“…The purposes of the present study were i) to determine whether neuropeptides induce the nasal obstruction in guinea pigs, and ii) to examine the possible…”
Get full text

Inhibitory Effect of KW-4679, an Anti-allergic Drug, on Tachykinin-Mediated Airway Response Induced by Electric Vagal Stimulation in Guinea Pigs by Ikemura, Toshihide, Sasaki, Yasuo, Ishii, Hidee, Ohmori, Kenji

“…We examined the effect of KW-4679 ((Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride), an anti-allergic drug,…”
Get full text

Modulation of neurogenic contraction in guinea-pig bronchus by KW-4679 by Ikemura, Toshihide, Ishii, Hidee, Sasaki, Yasuo, Ohmori, Kenji

“…We studied the effects of KW-4679, an anti-allergic drug, on neurogenic responses evoked by electrical field stimulation (EFS, 15V,0.5msec, 8Hz for 15sec) in…”
Get full text

Transfer of the Enhancing Effect of Respiratory Syncytial Virus Infection on Subsequent Allergic Airway Sensitization by T Lymphocytes by Schwarze, Jurgen, Makela, Mika, Cieslewicz, Grzegorz, Dakhama, Azzeddine, Lahn, Michael, Ikemura, Toshihide, Joetham, Anthony, Gelfand, Erwin W

“…In mice, respiratory syncytial virus (RSV) infection enhances allergic airway sensitization, resulting in lung eosinophilia and in airway hyperresponsiveness…”
Get full text

Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride' (olopatadine), an antiallergic drug by Ohmori, K, Ikemura, T, Kobayashi, H, Mukouyama, A

“…Olopatadine is a selective histamine H1-receptor antagonist possessing inhibitory effects on the release of inflammatory lipid mediators such as leukotriene…”
Get more information

KW‐4679‐induced inhibition of tachykininergic contraction in the guinea‐pig bronchi by prejunctional inhibition of peripheral sensory nerves by Ikemura, Toshihide, Okamura, Kyoko, Sasaki, Yasuo, Ishii, Hidee, Ohmori, Kenji

“…1 Sensory mechanisms play an important role in the vagal regulation of tracheobronchial smooth muscle tone. We examined the effect of KW‐4679, an anti‐allergic…”
Get full text