Search Results - "IKEDA, TOSHIHIKO"

Idiosyncratic drug hepatotoxicity: strategy for prevention and proposed mechanism by Ikeda, Toshihiko

“…Idiosyncratic drug toxicity has led to the market withdrawal of many drugs in the past. Since animal experiments are not predictive of such toxicity, the…”
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Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite by KAZUI, Miho, NISHIYA, Yumi, ISHIZUKA, Tomoko, HAGIHARA, Katsunobu, FARID, Nagy A, OKAZAKI, Osamu, IKEDA, Toshihiko, KURIHARA, Atsushi

“…The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel…”
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Drug-Induced Idiosyncratic Hepatotoxicity: Prevention Strategy Developed after the Troglitazone Case by Ikeda, Toshihiko

“…Troglitazone induced an idiosyncratic, hepatocellular injury-type hepatotoxicity in humans. Statistically, double null genotype of glutathione S-transferase…”
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Inhibition of Fatty Acid Synthesis Induces Apoptosis of Human Pancreatic Cancer Cells by Nishi, Koji, Suzuki, Kenta, Sawamoto, Junpei, Tokizawa, Yuma, Iwase, Yumiko, Yumita, Nagahiko, Ikeda, Toshihiko

“…Cancer cells tend to have a high requirement for lipids, including fatty acids, cholesterol and triglyceride, because of their rapid proliferative rate…”
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The Quantitative Prediction of CYP-mediated Drug Interaction by Physiologically Based Pharmacokinetic Modeling by Kato, Motohiro, Shitara, Yoshihisa, Sato, Hitoshi, Yoshisue, Kunihiro, Hirano, Masaru, Ikeda, Toshihiko, Sugiyama, Yuichi

“…Purpose The objective is to confirm if the prediction of the drug–drug interaction using a physiologically based pharmacokinetic (PBPK) model is more accurate…”
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A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel by HAGIHARA, Katsunobu, KAZUI, Miho, KURIHARA, Atsushi, YOSHIIKE, Michiharu, HONDA, Kokichi, OKAZAKI, Osamu, FARID, Nagy A, IKEDA, Toshihiko

“…The efficiency and interindividual variability in bioactivation of prasugrel and clopidogrel were quantitatively compared and the mechanisms involved were…”
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Involvement of reactive oxygen species in sonodynamically induced apoptosis using a novel porphyrin derivative by Yumita, Nagahiko, Iwase, Yumiko, Nishi, Koji, Komatsu, Hajime, Takeda, Kazuyoshi, Onodera, Kenji, Fukai, Toshio, Ikeda, Toshihiko, Umemura, Shin-Ichiro, Okudaira, Kazuho, Momose, Yasunori

“…In this study, we investigated the induction of apoptosis by ultrasound in the presence of the novel porphyrin derivative DCPH-P-Na(I). HL-60 cells were…”
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Changes in power generation performance of an undershot cross-flow-type hydraulic turbine in an irrigation channel due to snow masses passing through the rotor by Satou, Eiichi, Uchiyama, Tomomi, Takamure, Kotaro, Ikeda, Toshihiko, Okayama, Tomoko, Miyazawa, Tomoaki, Tsunashima, Daisuke

“…This study is focused on the development of a microhydraulic turbine that can stably and efficiently generate electricity even in channel where snow masses…”
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Hepatic microsomal thiol methyltransferase is involved in stereoselective methylation of pharmacologically active metabolite of prasugrel by Kazui, Miho, Hagihara, Katsunobu, Izumi, Takashi, Ikeda, Toshihiko, Kurihara, Atsushi

“…Prasugrel, a thienopyridine antiplatelet drug, is converted in animals and humans to the pharmacologically active metabolite R-138727…”
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Performance of nano-hydraulic turbine utilizing waterfalls by Ikeda, Toshihiko, Iio, Shouichiro, Tatsuno, Kenji

“…The aim of this investigation was to develop an environmentally friendly nano-hydraulic turbine utilizing waterfalls. A model of an impulse type hydraulic…”
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Comparison of Human Cytochrome P450 Inhibition by the Thienopyridines Prasugrel, Clopidogrel, and Ticlopidine by Hagihara, Katsunobu, Nishiya, Yumi, Kurihara, Atsushi, Kazui, Miho, Farid, Nagy A., Ikeda, Toshihiko

“…Differences in the inhibition of cytochrome P450 activities among thienopyridine antiplatelet agents, ticlopidine, clopidogrel, prasugrel, and the metabolites,…”
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A Novel Subunit Structure of Clostridium botulinum Serotype D Toxin Complex with Three Extended Arms by Hasegawa, Kimiko, Watanabe, Toshihiro, Suzuki, Tomonori, Yamano, Akihito, Oikawa, Tetsuo, Sato, Yasuhiko, Kouguchi, Hirokazu, Yoneyama, Tohru, Niwa, Koichi, Ikeda, Toshihiko, Ohyama, Tohru

“…The botulinum neurotoxins (BoNTs) are the most potent toxins known in nature, causing the lethal disease known as botulism in humans and animals. The BoNTs act…”
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Cost-effectiveness Analysis of Microdose Clinical Trials in Drug Development by Yamane, Naoe, Igarashi, Ataru, Kusama, Makiko, Maeda, Kazuya, Ikeda, Toshihiko, Sugiyama, Yuichi

“…Microdose (MD) clinical trials have been introduced to obtain human pharmacokinetic data early in drug development. Here we assessed the cost-effectiveness of…”
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Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine by Ishizuka, Tomoko, Fujimori, Izumi, Kato, Mitsunori, Noji-Sakikawa, Chisa, Saito, Motoko, Yoshigae, Yasushi, Kubota, Kazuishi, Kurihara, Atsushi, Izumi, Takashi, Ikeda, Toshihiko, Okazaki, Osamu

“…Olmesartan medoxomil (OM) is a prodrug type angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. Herein, we describe the…”
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Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma metabolism by Ishizuka, Tomoko, Fujimori, Izumi, Nishida, Atsuko, Sakurai, Hidetaka, Yoshigae, Yasushi, Nakahara, Kaori, Kurihara, Atsushi, Ikeda, Toshihiko, Izumi, Takashi

“…Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor antagonist. The OM-hydrolyzing enzyme responsible for prodrug bioactivation was…”
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Clinical Relevance of Liquid Chromatography Tandem Mass Spectrometry as an Analytical Method in Microdose Clinical Studies by Yamane, Naoe, Tozuka, Zenzaburo, Kusama, Makiko, Maeda, Kazuya, Ikeda, Toshihiko, Sugiyama, Yuichi

“…ABSTRACT Purpose To investigate the potency of LC-MS/MS by means of sensitivity and the applicability for cassette dosing in microdose clinical trials. Methods…”
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OATP1B1, OATP1B3, AND MRP2 ARE INVOLVED IN HEPATOBILIARY TRANSPORT OF OLMESARTAN, A NOVEL ANGIOTENSIN II BLOCKER by NAKAGOMI-HAGIHARA, Rie, NAKAI, Daisuke, KAWAI, Kenji, YOSHIGAE, Yasushi, TOKUI, Taro, ABE, Takaaki, IKEDA, Toshihiko

“…Hepatic uptake and biliary excretion of olmesartan, a new angiotensin II blocker, were investigated in vitro using human hepatocytes, cells expressing uptake…”
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Influence of Setting Condition on Characteristics of Savonius Hydraulic Turbine with a Shield Plate by Iio, Shouichiro, Katayama, Yusuke, Uchiyama, Fuminori, Sato, Eiichi, Ikeda, Toshihiko

“…The aim of this investigation was to improve power performance of Savonius hydraulic turbine utilizing small stream for electric generation.An attempt was made…”
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Idiosyncratic drug toxicity by Ikeda, Toshihiko

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Sonodynamically-induced cytotoxicity by rose bengal derivative and microbubbles in isolated sarcoma 180 cells by Sugita, Nami, Hosokawa, Mami, Sunaga, Naoki, Iwase, Yumiko, Yumita, Nagahiko, Ikeda, Toshihiko, Umemura, Shin-ichiro

“…It is known that the combination of ultrasound and sonodynamic sensitizer (SDS) is effective in noninvasive tumor treatment, referred to as sonodynamic therapy…”
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