Search Results - "IKEDA, Shohei"

The role of autophagy in death of cardiomyocytes by Ikeda, Shohei, Zablocki, Daniela, Sadoshima, Junichi

“…Autophagy mediates cellular quality control mechanisms and energy homeostasis through lysosomal degradation. Autophagy is typically viewed as an adaptive…”
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Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy by Tong, Mingming, Saito, Toshiro, Zhai, Peiyong, Oka, Shin-ichi, Mizushima, Wataru, Nakamura, Michinari, Ikeda, Shohei, Shirakabe, Akihiro, Sadoshima, Junichi

“…RATIONALE:Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic dysfunction, and intracellular lipid accumulation, termed…”
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Regulation of Myocardial Cell Growth and Death by the Hippo Pathway by Ikeda, Shohei, Sadoshima, Junichi

“…Stress in the heart causes loss of cardiomyocytes (CMs), the accumulation of which leads to heart failure, a major cause of clinical mortality. The improvement…”
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Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy by Tong, Mingming, Saito, Toshiro, Zhai, Peiyong, Oka, Shin-ichi, Mizushima, Wataru, Nakamura, Michinari, Ikeda, Shohei, Shirakabe, Akihiro, Sadoshima, Junichi

“…Obesity-associated cardiomyopathy characterized by hypertrophy and mitochondrial dysfunction. Mitochondrial quality control mechanisms, including mitophagy,…”
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Ultrastructural mechanisms of macrophage-induced demyelination in CIDP by Koike, Haruki, Nishi, Ryoji, Ikeda, Shohei, Kawagashira, Yuichi, Iijima, Masahiro, Katsuno, Masahisa, Sobue, Gen

“…Chronic inflammatory demyelinating polyneuropathy (CIDP) is a form of chronic neuropathy that is presumably caused by heterogeneous immune-mediated processes…”
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Clinicopathological characteristics of subtypes of chronic inflammatory demyelinating polyradiculoneuropathy by Ikeda, Shohei, Koike, Haruki, Nishi, Ryoji, Kawagashira, Yuichi, Iijima, Masahiro, Katsuno, Masahisa, Sobue, Gen

“…ObjectiveTo evaluate the clinical and pathological correlations characterising each clinical subtype of chronic inflammatory demyelinating…”
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Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload by Byun, Jaemin, Del Re, Dominic P., Zhai, Peiyong, Ikeda, Shohei, Shirakabe, Akihiro, Mizushima, Wataru, Miyamoto, Shigeki, Brown, Joan H., Sadoshima, Junichi

“…Cardiovascular disease (CVD) remains the leading cause of death globally, and heart failure is a major component of CVD-related morbidity and mortality. The…”
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NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart by Matsuda, Takahisa, Zhai, Peiyong, Sciarretta, Sebastiano, Zhang, Yu, Jeong, Jae Im, Ikeda, Shohei, Park, Jiyeon, Hsu, Chiao-Po, Tian, Bin, Pan, Duojia, Sadoshima, Junichi, Del Re, Dominic P

“…RATIONALE:NF2 (neurofibromin 2) is an established tumor suppressor that promotes apoptosis and inhibits growth in a variety of cell types, yet its function in…”
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Primary Experiences with Robot-assisted Navigation-based Frameless Stereo-electroencephalography: Higher Accuracy than Neuronavigation-guided Manual Adjustment by KOJIMA, Yuichiro, UDA, Takehiro, KAWASHIMA, Toshiyuki, KOH, Saya, HATTORI, Masato, MITO, Yuki, KUNIHIRO, Noritsugu, IKEDA, Shohei, UMABA, Ryoko, GOTO, Takeo

“…The use of robot-assisted frameless stereotactic electroencephalography (SEEG) is becoming more common. Among available robotic arms, Stealth Autoguide (SA)…”
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Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload by Ikeda, Shohei, Mizushima, Wataru, Sciarretta, Sebastiano, Abdellatif, Maha, Zhai, Peiyong, Mukai, Risa, Fefelova, Nadezhda, Oka, Shin-ichi, Nakamura, Michinari, Del Re, Dominic P, Farrance, Iain, Park, Ji Yeon, Tian, Bin, Xie, Lai-Hua, Kumar, Mohit, Hsu, Chiao-Po, Sadayappan, Sakthivel, Shimokawa, Hiroaki, Lim, Dae-Sik, Sadoshima, Junichi

“…RATIONALE:The Hippo pathway plays an important role in determining organ size through regulation of cell proliferation and apoptosis. Hippo inactivation and…”
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Schwann cell and endothelial cell damage in transthyretin familial amyloid polyneuropathy by Koike, Haruki, Ikeda, Shohei, Takahashi, Mie, Kawagashira, Yuichi, Iijima, Masahiro, Misumi, Yohei, Ando, Yukio, Ikeda, Shu-ichi, Katsuno, Masahisa, Sobue, Gen

“…OBJECTIVE:To examine the morphology of Schwann cells and endoneurial microvessels with electron microscopy. METHODS:Sural nerve biopsy specimens from 49…”
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Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice by Sunamura, Shinichiro, Satoh, Kimio, Kurosawa, Ryo, Ohtsuki, Tomohiro, Kikuchi, Nobuhiro, Elias-Al-Mamun, Md, Shimizu, Toru, Ikeda, Shohei, Suzuki, Kota, Satoh, Taijyu, Omura, Junichi, Nogi, Masamichi, Numano, Kazuhiko, Siddique, Mohammad Abdul Hai, Miyata, Satoshi, Miura, Masahito, Shimokawa, Hiroaki

“…Although postcapillary pulmonary hypertension (PH) is an important prognostic factor for patients with heart failure (HF), its pathogenesis remains to be fully…”
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YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases by Ikeda, Shohei, Nah, Jihoon, Shirakabe, Akihiro, Zhai, Peiyong, Oka, Shin-Ichi, Sciarretta, Sebastiano, Guan, Kun-Liang, Shimokawa, Hiroaki, Sadoshima, Junichi

“…Lysosomal dysfunction caused by mutations in lysosomal genes results in lysosomal storage disorder (LSD), characterized by accumulation of damaged proteins and…”
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Incorporation and conduction of proton in Sr-doped LaMO3 (M=Al, Sc, In, Yb, Y) by Okuyama, Yuji, Kozai, Takeshi, Ikeda, Shohei, Matsuka, Maki, Sakai, Takaaki, Matsumoto, Hiroshige

“…In order to clarify the effect of the B site species in ABO3 perovskite oxides on the proton transport properties, the proton incorporation into a series of…”
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Crucial Role of ROCK2 in Vascular Smooth Muscle Cells for Hypoxia-Induced Pulmonary Hypertension in Mice by Shimizu, Toru, Fukumoto, Yoshihiro, Tanaka, Shin-ichi, Satoh, Kimio, Ikeda, Shohei, Shimokawa, Hiroaki

“…OBJECTIVE—Rho/Rho-kinase (ROCK) pathway in vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of cardiovascular diseases,…”
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Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody by Fukushima, Taiki, Ikeda, Shohei, Tomita, Minoru, Mori, Yu, Fukami, Yuki, Koike, Haruki, Katsuno, Masahisa, Ogata, Hidenori, Isobe, Noriko, Hattori, Naoki

“…We herein report a 77-year-old man with a 4-month history of progressive gait and sensory disturbances of the extremities. A nerve conduction study indicated…”
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Disruption of Physiological Balance Between Nitric Oxide and Endothelium-Dependent Hyperpolarization Impairs Cardiovascular Homeostasis in Mice by Godo, Shigeo, Sawada, Ayuko, Saito, Hiroki, Ikeda, Shohei, Enkhjargal, Budbazar, Suzuki, Kota, Tanaka, Shuhei, Shimokawa, Hiroaki

“…OBJECTIVE—Endothelium-derived nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) play important roles in modulating vascular tone in a…”
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Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice by Nakamura, Michinari, Keller, Mariko Aoyagi, Fefelova, Nadezhda, Zhai, Peiyong, Liu, Tong, Tian, Yimin, Ikeda, Shohei, Del Re, Dominic P., Li, Hong, Xie, Lai-Hua, Sadoshima, Junichi

“…The anti-apoptotic function of Bcl-xL in the heart during ischemia/reperfusion is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows…”
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Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition by Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.

“…[Display omitted] •YAP is activated by myocardial infarction or neuroendocrine stimulation in cardiac fibroblasts.•Active YAP promotes TEA domain transcription…”
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Serum IgG and lymphocyte counts are useful for the early detection of infection in patients receiving bendamustine-rituximab therapy by Suzuki, Manabu, Koyama, Daisuke, Ikeda, Shohei, Sukegawa, Masumi, Teshirogi, Mayumi, Misawa, Kyohei, Tsunoda, Saburo

“…Bendamustine-rituximab (BR) therapy has been established as a highly effective regimen for indolent non-Hodgkin lymphoma (NHL). However, patients who receive…”
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