Search Results - "IKEDA, Eiji"
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Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells
Published in Circulation research (01-02-2013)“…The enthusiasm for producing patient-specific human embryonic stem cells using somatic nuclear transfer has somewhat abated in recent years because of ethical,…”
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Intravenous injection of cyclophilin A realizes the transient and reversible opening of barrier of neural vasculature through basigin in endothelial cells
Published in Scientific reports (29-09-2021)“…Neural vasculature forms the blood–brain barrier against the delivery of systemically administered therapeutic drugs into parenchyma of neural tissues…”
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Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
Published in Proceedings of the National Academy of Sciences - PNAS (04-10-2011)“…Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs), which do not entail ethical concerns, may become a preferred cell source for…”
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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Published in Cell stem cell (03-01-2013)“…Defining the metabolic programs that underlie stem cell maintenance will be essential for developing strategies to manipulate stem cell capacity. Mammalian…”
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Hypoxia-induced disruption of neural vascular barrier is mediated by the intracellular induction of Fe(II) ion
Published in Experimental cell research (15-06-2019)“…Neural vascular barrier maintains the optimal tissue microenvironment of central nervous system in which neural cells can function normally. In various neural…”
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Variation in the safety of induced pluripotent stem cell lines
Published in Nature biotechnology (01-08-2009)“…We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11…”
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Preoperative neutrophil-to-lymphocyte ratio correlates with PD-L1 expression in immune cells of patients with malignant pleural mesothelioma and predicts prognosis
Published in Scientific reports (31-03-2023)“…We assessed the prognostic value of five complex inflammatory and nutritional parameters, namely neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional…”
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Histological Characterization of the Tumorigenic "Peri-Necrotic Niche" Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma
Published in PloS one (22-01-2016)“…Characterization of the niches for stem-like tumor cells is important to understand and control the behavior of glioblastomas. Cell-cycle quiescence might be a…”
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Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
Published in Nature communications (10-05-2016)“…The naked mole-rat (NMR, Heterocephalus glaber ), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that…”
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Characterizing soluble immune checkpoint molecules and TGF-β1,2,3 in pleural effusion of malignant pleural mesothelioma
Published in Scientific reports (10-07-2024)“…The clinical impact of soluble molecules in pleural effusion (PE) is unclear in patients with malignant pleural mesothelioma (MPM). In this single-center,…”
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Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
Published in Proceedings of the National Academy of Sciences - PNAS (13-07-2010)“…Various types of induced pluripotent stem (iPS) cells have been established by different methods, and each type exhibits different biological properties…”
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Cellular response to tissue hypoxia and its involvement in disease progression
Published in Pathology international (01-10-2005)“…Multicellular organisms show adaptive reactions for their survival when they are exposed to an atmosphere with reduced oxygen concentration. These reactions…”
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Effects of the tendency of developing neurodevelopmental disorder on subjective evaluation of distance learning among university students
Published in PCN reports (01-06-2024)Get full text
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MRI findings and pathological features in early-stage glioblastoma
Published in Journal of neuro-oncology (01-06-2015)“…Magnetic resonance imaging (MRI) is an important diagnostic tool for glioblastoma, with almost all cases showing characteristic imaging findings such as a…”
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Expert perspectives on pathological findings in vasculitis
Published in Modern rheumatology (03-01-2023)“…Pathological findings are important in the diagnosis of vasculitis. However, due to the rarity of the disease, standard textbooks usually devote only a few…”
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Long-Term Safety Issues of iPSC-Based Cell Therapy in a Spinal Cord Injury Model: Oncogenic Transformation with Epithelial-Mesenchymal Transition
Published in Stem cell reports (10-03-2015)“…Previously, we described the safety and therapeutic potential of neurospheres (NSs) derived from a human induced pluripotent stem cell (iPSC) clone, 201B7, in…”
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Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma
Published in Journal of cancer research and clinical oncology (01-02-2019)“…Purpose Glioblastoma is still intractable despite the progress in therapies, and the intractability is attributable to a minor population of stem-like tumor…”
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Eyes Closing and Drowsiness in Human Subjects Decrease Baseline Galvanic Skin Response and Active Palmar Sweating: Relationship Between Galvanic Skin and Palmar Perspiration Responses
Published in Frontiers in physiology (10-12-2020)“…We previously constructed a perspiration ratemeter for the measurement of palmar sweating in human subjects. Although galvanic skin response (GSR) has been…”
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