Search Results - "IIDA, Yuichi"

Supplementation of l‐arginine boosts the therapeutic efficacy of anticancer chemoimmunotherapy by Satoh, Yusuke, Kotani, Hitoshi, Iida, Yuichi, Taniura, Takahito, Notsu, Yoshitomo, Harada, Mamoru

“…Myeloid‐derived suppressor cells (MDSCs) play a crucial role in immunosuppression in tumor‐bearing hosts. MDSCs express arginase‐I and indoleamine…”
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Immunogenic chemotherapy in two mouse colon cancer models by Taniura, Takahito, Iida, Yuichi, Kotani, Hitoshi, Ishitobi, Kazunari, Tajima, Yoshitsugu, Harada, Mamoru

“…Aside from the induction of cell death, some anticancer chemotherapeutic drugs can modulate antitumor immune responses. In this study, we examined the…”
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Contrasting effects of cyclophosphamide on anti‐CTL‐associated protein 4 blockade therapy in two mouse tumor models by Iida, Yuichi, Harashima, Nanae, Motoshima, Takanobu, Komohara, Yoshihiro, Eto, Masatoshi, Harada, Mamoru

“…Immune checkpoint blockade is a promising anticancer therapy, but must be used in combination with other anticancer therapies to increase its therapeutic…”
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Different sensitivities of senescent breast cancer cells to immune cell‐mediated cytotoxicity by Inao, Touko, Kotani, Hitoshi, Iida, Yuichi, Kartika, Irna Diyana, Okimoto, Tamio, Tanino, Ryosuke, Shiba, Eiichi, Harada, Mamoru

“…Senescence is a state of growth arrest induced not only in normal cells but also in cancer cells by aging or stress, which triggers DNA damage. Despite growth…”
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Pemetrexed sensitizes human lung cancer cells to cytotoxic immune cells by Okimoto, Tamio, Kotani, Hitoshi, Iida, Yuichi, Koyanagi, Akira, Tanino, Ryosuke, Tsubata, Yukari, Isobe, Takeshi, Harada, Mamoru

“…Pemetrexed (PEM) is a useful drug that can be combined with immune checkpoint blockade therapy for treatment of patients with advanced non–small‐cell lung…”
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A modulatory effect of L-arginine supplementation on anticancer effects of chemoimmunotherapy in colon cancer-bearing aged mice by Ishitobi, Kazunari, Kotani, Hitoshi, Iida, Yuichi, Taniura, Takahito, Notsu, Yoshitomo, Tajima, Yoshitsugu, Harada, Mamoru

“…•Combined immunogenic chemotherapy with 5-fluorouracil/oxaliplatin and cyclophosphamide in two mouse colon cancer models.•Compared to young mice, the effect of…”
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Bcl-2 inhibition sensitizes triple-negative human breast cancer cells to doxorubicin by Inao, Touko, Iida, Yuichi, Moritani, Tamami, Okimoto, Tamio, Tanino, Ryosuke, Kotani, Hitoshi, Harada, Mamoru

“…Breast cancers can be divided into several types. Because triple-negative breast cancer (TNBC) is the most refractory to current anti-cancer therapies,…”
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Chloroquine augments TRAIL-induced apoptosis and induces G2/M phase arrest in human pancreatic cancer cells by Monma, Hiroyuki, Iida, Yuichi, Moritani, Tamami, Okimoto, Tamio, Tanino, Ryosuke, Tajima, Yoshitsugu, Harada, Mamoru

“…Autophagy contributes to the treatment-resistance of many types of cancers, and chloroquine (CQ) inhibits autophagy. The tumor necrosis factor (TNF)-related…”
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Rejuvenation of human mesenchymal stem cells using a nonintegrative and conditionally removable Sendai virus vector by Oshimura, Mitsuo, Tabata, Toshiaki, Uno, Narumi, Takata, Shuta, Hichiwa, Genki, Kanazawa, Iori, Endo, Takeshi, Honma, Kazuhisa, Wang, Yayan, Kazuki, Kanako, Tu, Haochen, Iida, Yuichi, Abe, Satoshi, Kazuki, Yasuhiro

“…Human mesenchymal stem cells (hMSCs) with extended lifespan and differentiation potential that can recapitulate in vivo characteristics could significantly…”
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T-cell responses and combined immunotherapy against human carbonic anhydrase 9-expressing mouse renal cell carcinoma by Harada, Mamoru, Iida, Yuichi, Kotani, Hitoshi, Minami, Takafumi, Komohara, Yoshihiro, Eto, Masatoshi, Yoshikawa, Kazuhiro, Uemura, Hirotsugu

“…Renal cell carcinoma (RCC) is known to respond to immune checkpoint blockade (ICB) therapy, whereas there has been limited analysis of T-cell responses to RCC…”
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Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells by Hoque, Mohammad Mahbubul, Iida, Yuichi, Kotani, Hitoshi, Harada, Mamoru

“…Introduction Gemcitabine (GEM) is often used to treat pancreatic cancer. Many anti‐cancer drugs induce cancer cell death, but some cells survive after cell…”
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Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism by Uehara, Shotaro, Iida, Yuichi, Ida-Tanaka, Miyuki, Goto, Motohito, Kawai, Kenji, Yamamoto, Masafumi, Higuchi, Yuichiro, Ito, Satoshi, Takahashi, Riichi, Kamimura, Hidetaka, Ito, Mamoru, Yamazaki, Hiroshi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Suemizu, Hiroshi

“…Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans. However, residual mouse…”
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Protective roles of cytoplasmic p21Cip1/Waf1 in senolysis and ferroptosis of lung cancer cells by Koyanagi, Akira, Kotani, Hitoshi, Iida, Yuichi, Tanino, Ryosuke, Kartika, Irna D., Kishimoto, Koji, Harada, Mamoru

“…Objective Therapy‐induced senescent cancer cells increase the expression of the cyclin‐dependent kinase inhibitors p16Ink4a and p21Cip1/Waf1. Given that p21…”
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Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells by Iida, Yuichi, Yoshikawa, Rintaro, Murata, Akihiko, Kotani, Hitoshi, Kazuki, Yasuhiro, Oshimura, Mitsuo, Matsuzaki, Yumi, Harada, Mamoru

“…Mesenchymal stem/stromal cells (MSC) accumulate and reside in tumor sites. Taking advantage of this feature in anticancer therapy, immortalized murine MSC…”
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Protective role of cytoplasmic p21Cip1/Waf1 in apoptosis of CDK4/6 inhibitor‐induced senescence in breast cancer cells by Kartika, Irna D., Kotani, Hitoshi, Iida, Yuichi, Koyanagi, Akira, Tanino, Ryosuke, Harada, Mamoru

“…Inhibition of CDK4/6 slows the cell cycle and induces senescence in breast cancer cells. However, senescent cancer cells promote invasion and metastasis…”
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Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells by Kim, Jung-Hyun, Kononenko, Artem, Erliandri, Indri, Kim, Tae-Aug, Nakano, Megumi, Iida, Yuichi, Barrett, J. Carl, Oshimura, Mitsuo, Masumoto, Hiroshi, Earnshaw, William C, Larionov, Vladimir, Kouprina, Natalay

“…Human artificial chromosome (HAC)-based vectors offer a promising system for delivery and expression of full-length human genes of any size. HACs avoid the…”
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Hydroxychloroquine Promotes Bcl-xL Inhibition-induced Apoptosis in BxPC-3 Human Pancreatic Cancer Cells by HOQUE, MOHAMMAD MAHBUBUL, IIDA, YUICHI, KOTANI, HITOSHI, KARTIKA, IRNA DIYANA, HARADA, MAMORU

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Integration-free and stable expression of FVIII using a human artificial chromosome by Kurosaki, Hajime, Hiratsuka, Masaharu, Imaoka, Natsuko, Iida, Yuichi, Uno, Narumi, Kazuki, Yasuhiro, Ishihara, Chie, Yakura, Yuwna, Mimuro, Jun, Sakata, Youichi, Takeya, Hiroyuki, Oshimura, Mitsuo

“…Human artificial chromosome (HAC) has several advantages as a gene therapy vector, including stable episomal maintenance that avoids insertional mutations and…”
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Bi-HAC Vector System toward Gene and Cell Therapy by Iida, Yuichi, Kazuki, Yasuhiro, Hayashi, Masahiro, Ueda, Yasuji, Hasegawa, Mamoru, Kouprina, Natalay, Larionov, Vladimir, Oshimura, Mitsuo

“…Genetic manipulations with mammalian cells often require introduction of two or more genes that have to be in trans-configuration. However, conventional gene…”
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Preparation of Highly Dispersed Ultrafine Barium Titanate Powder by Using Microbial-Derived Surfactant by Kamiya, Hidehiro, Gomi, Kenjiro, Iida, Yuichi, Tanaka, Kenji, Yoshiyasu, Takashi, Kakiuchi, Toshihito

“…To uniformly disperse ultrafine BaTiO3 particles with a stoichiometric composition and several tens of nanometers in diameter to primary particles during the…”
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