Search Results - "IHNAT, M. A"

'Glycaemic variability': a new therapeutic challenge in diabetes and the critical care setting by Ceriello, A., Ihnat, M. A.

“…Diabet. Med. 27, 862–867 (2010) Much attention has been paid recently to the possibility that oscillating glucose may superimpose on glycated haemoglobin…”
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Hypothesis: the 'metabolic memory', the new challenge of diabetes by Ihnat, M. A., Thorpe, J. E., Ceriello, A.

“…Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro‐ and macrovascular…”
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Reactive oxygen species mediate a cellular 'memory' of high glucose stress signalling by Ihnat, M. A, Thorpe, J. E, Kamat, C. D, Szabó, C, Green, D. E, Warnke, L. A, Lacza, Z, Cselenyák, A, Ross, K, Shakir, S, Piconi, L, Kaltreider, R. C, Ceriello, A

“…Aims/hypothesis A long-term 'memory' of hyperglycaemic stress, even when glycaemia is normalised, has been previously reported in endothelial cells. In this…”
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Hypoxia triggers a HIF-mediated differentiation of peripheral blood mononuclear cells into osteoclasts by Dandajena, T. C., Ihnat, M. A., Disch, B., Thorpe, J., Currier, G. F.

“…Dandajena T. C., Ihnat M. A., Disch B., Thorpe J., Currier G. F. Hypoxia triggers a HIF‐mediated differentiation of peripheral blood mononuclear cells into…”
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Geochemical characterization and renal cell toxicity of water-soluble extracts from U.S. Gulf Coast lignite by Ojeda, A. S., Ford, S. D., Gallucci, R. M., Ihnat, M. A., Philp, R. P.

“…An assortment of organic material can leach from lignite (low-rank coal) in water, and the water-soluble fraction from lignite has been associated with adverse…”
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Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents by IHNAT, M. A, LARIVIERE, J. P, WARREN, A. J, LA RONDE, N, BLAXALL, J. R. N, PIERRE, K. M, TURPIE, B. W, HAMILTON, J. W

“…Overexpression of the trans-membrane drug efflux pump P-glycoprotein is one of the major mechanisms by which cancer cells develop multidrug resistance. We…”
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Developmental regulation of the 3-methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo by BENTIVEGNA, C. S, IHNAT, M. A, BAPTISTE, N. S, HAMILTON, J. W

“…The cDNA sequences for two dioxin-inducible cytochrome P450s in chicken, CYP1A4 and CYP1A5, have recently been reported which correspond to two…”
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Binding of nuclear proteins associated with mammalian DNA repair to the mitomycin C-DNA interstrand crosslink by Warren, Amy J., Ihnat, Michael A., Ogdon, Sara E., Rowell, Erin E., Hamilton, Joshua W.

“…Mitomycin C (MMC) is a DNA crosslinking agent that is used in cancer chemotherapy. Unlike the DNA crosslinks formed by cisplatin or psoralen, which…”
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Molecular Basis for Effects of Carcinogenic Heavy Metals on Inducible Gene Expression by Hamilton, Joshua W., Kaltreider, Ronald C., Bajenova, Olga V., Ihnat, Michael A., McCaffrey, Jennifer, Turpie, Bruce W., Rowell, Erin E., Oh, Jannet, Nemeth, Michael J., Pesce, Carrie A., Lariviere, Jean P.

“…Certain forms of the heavy metals arsenic and chromium are considered human carcinogens, although they are believed to act through very different mechanisms…”
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Structure-activity relationship of glycine betaine analogs on osmotolerance of enteric bacteria by Abdel-Ghany, Yasser S, Ihnat, Michael A, Miller, Duane D, Kunin, Calvin M, Tong, Hua H

“…Bacterial cells have the ability to accumulate compatible solutes within the cytoplasm to maintain their osmolarity above that of the extracellular milieu…”
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Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding by Kaltreider, Ronald C., Pesce, Carrie A., Ihnat, Michael A., Lariviere, Jean P., Hamilton, Joshua W.

“…The toxic metals arsenic(III) and chromium(VI) are considered human carcinogens, although they may act through different mechanisms. We previously showed that…”
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Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation by Marks, Megan G., Shi, Jiandong, Fry, Michael O., Xiao, Zili, Trzyna, Michelle, Pokala, Vedavalli, Ihnat, Michael A., Li, Pui-Kai

“…Angiogenesis, in particular anti-angiogenesis, is an area of particular therapeutic interest in cancer treatment. Several anti-angiogenic agents are in the…”
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Growth of human tumor cells in macroporous microcarriers results in p53-independent, decreased cisplatin sensitivity relative to monolayers by Maurer, B J, Ihnat, M A, Morgan, C, Pullman, J, O'Brien, C, Johnson, S W, Rasey, J S, Cornwell, M M

“…Multicellular contact has been shown to influence the in vitro sensitivity of cells to drug treatment. We investigated the use of macroporous gelatin…”
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Effects of mitomycin C and carboplatin pretreatment on multidrug resistance-associated P-glycoprotein expression and on subsequent suppression of tumor growth by doxorubicin and paclitaxel in human metastatic breast cancer xenografted nude mice by Ihnat, M A, Nervi, A M, Anthony, S P, Kaltreider, R C, Warren, A J, Pesce, C A, Davis, S A, Lariviere, J P, Hamilton, J W

“…Overexpression of P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP), and several other proteins has been associated with development of…”
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Arsenic Stimulates Angiogenesis and Tumorigenesis In Vivo by Soucy, Nicole V., Ihnat, Michael A., Kamat, Chandrashekhar D., Hess, Linda, Post, Mark J., Klei, Linda R., Clark, Callie, Barchowsky, Aaron

“…Trivalent inorganic arsenic (arsenite, arsenic trioxide, As[III]) is currently being used to treat hematologic tumors and is being investigated for treating…”
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Role of HIF Signaling on Tumorigenesis in Response to Chronic Low-Dose Arsenic Administration by Kamat, Chandrashekhar D., Green, Dixy E., Curilla, Susan, Warnke, Linda, Hamilton, Joshua W., Sturup, Stefan, Clark, Callie, Ihnat, Michael A.

“…Trivalent inorganic arsenic (arsenite, arsenic trioxide, As(III)) is a primary contaminant of groundwater supplies worldwide. As(III), marketed as trisenox, is…”
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SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts by Luckett-Chastain, Lerin R, Ihnat, Michael A, Mickle-Kawar, Bethany M, Gallucci, Randle Michael

“…This study aims to investigate the mechanisms in the apparent preference for mitogen-activated protein kinase /ERK signaling through interleukin (IL)-6R in…”
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Antiangiogenic and antitumor agents: Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases by GANGJEE, Aleem, JIE YANG, IHNAT, Michael A, KAMAT, Shekhar

“…Several different classes of growth factor receptors containing tyrosine kinases (RTK) are directly or indirectly involved in angiogenesis. Inhibition of these…”
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Molecular Basis for Effects of Carcinogenic Heavy Metals on Inducible Gene Expression by Hamilton, Joshua W., Kaltreider, Ronald C., Bajenova, Olga V., Ihnat, Michael A., McCaffrey, Jennifer, Turpie, Bruce W., Rowell, Erin E., Oh, Jannet, Nemeth, Michael J., Pesce, Carrie A., Lariviere, Jean P.

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Structure–activity relationships studies of the anti-angiogenic activities of linomide by Shi, Jiandong, Xiao, Zili, Ihnat, Michael A, Kamat, Chandrashekhar, Pandit, Bulbul, Hu, Zhigen, Li, Pui-Kai

“…The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3–69 times more potent than linomide at…”
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