Search Results - "IHLE, N. C"

Reduction−Alkylation Strategies for the Modification of Specific Monoclonal Antibody Disulfides by Sun, Michael M. C, Beam, Kevin S, Cerveny, Charles G, Hamblett, Kevin J, Blackmore, Richard S, Torgov, Michael Y, Handley, Felicia G. M, Ihle, Nathan C, Senter, Peter D, Alley, Stephen C

“…Site-specific conjugation of small molecules and enzymes to monoclonal antibodies has broad utility in the formation of conjugates for therapeutic, diagnostic,…”
Get full text

Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217 by Cook, J J, Holahan, M A, Lyle, E A, Ramjit, D R, Sitko, G R, Stranieri, M T, Stupienski, 3rd, R F, Wallace, A A, Hand, E L, Gehret, J R, Kothstein, T, Drag, M D, McCormick, G Y, Perkins, J J, Ihle, N C, Duggan, M E, Hartman, G D, Gould, R J, Lynch, Jr, J J

“…The antiplatelet activity of L-734,217, a nonpeptide platelet GPIIb/IIIa antagonist, was evaluated in the rat, guinea pig and dog. IC50 for inhibition of in…”
Get more information

Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist by Duggan, M E, Duong, L T, Fisher, J E, Hamill, T G, Hoffman, W F, Huff, J R, Ihle, N C, Leu, C T, Nagy, R M, Perkins, J J, Rodan, S B, Wesolowski, G, Whitman, D B, Zartman, A E, Rodan, G A, Hartman, G D

“…Modification of the potent fibrinogen receptor (alpha(IIb)beta(3)) antagonist 1 generated compounds with high affinity for the vitronectin receptor…”
Get full text

Nicotinamide N-oxides as CXCR2 antagonists by CUTSHALL, Neil S, URSINO, Rocky, KUCERA, Kristin A, LATHAM, John, IHLE, Nathan C

“…A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds…”
Get full text

Palladium-catalyzed intramolecular alkyne-carbon monoxide-alkene insertion cascade for synthesis of .alpha.-methylenecyclopentenones by Ihle, Nathan C, Heathcock, Clayton H

Get full text

Nickel-catalyzed intramolecular [4 + 4]-cycloadditions: a new method for the synthesis of polycycles containing eight-membered rings by Wender, Paul A, Ihle, Nathan C

Get full text

Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide by Meissner, Robert S, Perkins, James J, Duong, Le T, Hartman, George D, Hoffman, William F, Huff, Joel R, Ihle, Nathan C, Leu, Chih Tai, Nagy, Rose M, Naylor-Olsen, Adel, Rodan, Gideon A, Rodan, Sevgi B, Whitman, David B, Wesolowski, Gregg A, Duggan, Mark E

“…Mimetics of the RGD tripeptide are described that are potent, selective antagonists of the integrin receptor, alpha(v)beta(3). The use of the…”
Get full text

Non-peptide fibrinogen receptor antagonists. 7. Design and synthesis of a potent, orally active fibrinogen receptor antagonist by Duggan, M E, Naylor-Olsen, A M, Perkins, J J, Anderson, P S, Chang, C T, Cook, J J, Gould, R J, Ihle, N C, Hartman, G D, Lynch, J J

“…The design, synthesis, and pharmacological evaluation of L-734,217, a potent, low-molecular weight, orally active fibrinogen receptor antagonist, is reported…”
Get full text

Nickel-catalyzed intramolecular [4+4] cycloadditions. IV: Enantioselective total synthesis of (+)-asteriscanolide by WENDER, P. A, IHLE, N. C, CORREIA, C. R. D

Get full text

Non-peptide fibrinogen receptor antagonists. VII: Design and synthesis of a potent, orally active fibrinogen receptor antagonist by DUGGAN, M. E, NAYLOR-OLSEN, A. M, LYNCH, R. J, MANNO, P. D, SCHAFFER, L. W, SMITH, R. L, PERKINS, J. J, ANDERSON, P. S, CHANG, C. T.-C, COOK, J. J, GOULD, R. J, IHLE, N. C, HARTMAN, G. D, LYNCH, J. J

Get full text

Nicotinanilides as inhibitors of neutrophil chemotaxis by Cutshall, Neil S., Kucera, Kristin A., Ursino, Rocky, Latham, John, Ihle, Nathan C.

“…A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-α-driven human neutrophil chemotaxis…”
Get full text

Preparation of 4-Alkyl-2-[N-(tert-butoxycarbonyl)amino]pyridines by Alkylation, Nucleophilic Addition, and Acylation of 2-[N-(tert-Butoxycarbonyl)amino]-4-picoline(1) by Ihle, Nathan C., Krause, Amy E.

Get full text