Search Results - "IGNATENKO, Natalia A"

Specific microRNA–mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein–Related Peptidase 6 by Sells, Earlphia, Pandey, Ritu, Chen, Hwudaurw, Skovan, Bethany A, Cui, Haiyan, Ignatenko, Natalia A

“…Abstract Metastatic colon cancer is a major cause of deaths among colorectal cancer (CRC) patients. Elevated expression of kallikrein 6 (KLK6), a member of a…”
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Digital image analysis using video microscopy of human-derived prostate cancer vs normal prostate organoids to assess migratory behavior on extracellular matrix proteins by Marr, Kendra D, Ignatenko, Natalia A, Warfel, Noel A, Batai, Ken, Cress, Anne E, Pollock, Grant R, Wong, Ava C, Lee, Benjamin R

“…The advent of perpetuating living organoids derived from patient tissue is a promising avenue for cancer research but is limited by difficulties with precise…”
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Caveolin‐1 is a novel regulator of K‐RAS‐dependent migration in colon carcinogenesis by Basu Roy, Upal K., Henkhaus, Rebecca S., Loupakis, Fotios, Cremolini, Chiara, Gerner, Eugene W., Ignatenko, Natalia A.

“…Caveolin‐1 is an essential component of membrane caveolae. It is an important regulator of cellular processes such as signal transduction and endocytosis. We…”
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Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis by Bouzid, Hayet, Soualmia, Feryel, Oikonomopoulou, Katerina, Soosaipillai, Antoninus, Walker, Francine, Louati, Khaoula, Lo Dico, Rea, Pocard, Marc, El Amri, Chahrazade, Ignatenko, Natalia A., Darmoul, Dalila

“…Kallikrein-related peptidases (KLKs) are implicated in many cancer-related processes. KLK6, one of the 15 KLK family members, is a promising biomarker for…”
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Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer by Babbar, Naveen, Ignatenko, Natalia A, Casero, Jr, Robert A, Gerner, Eugene W

“…Sulindac, a non-steroidal anti-inflammatory prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives. Sulindac sulfide, but not…”
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Caveolin-1-Mediated Expression and Secretion of Kallikrein 6 in Colon Cancer Cells by Henkhaus, Rebecca S., Roy, Upal Kunal Basu, Cavallo-Medved, Dora, Sloane, Bonnie F., Gerner, Eugene W., Ignatenko, Natalia A.

“…Kallikreins are secreted proteases that may play a functional role and/or serve as a serum biomarker for the presence or progression of certain types of…”
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Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc by Roy, Upal K. Basu, Henkhaus, Rebecca S., Ignatenko, Natalia A., Mora, Jessica, Fultz, Kimberly E., Gerner, Eugene W.

“…Genetic evidence suggests that caveolin‐1, an essential component of membrane caveolae, acts as a tumor promoter in some, and a tumor suppressor in other…”
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HuRrying colon cancer progression by Ignatenko, Natalia A., Gerner, Eugene W.

“…Commentary to: Increased expression of cytoplasmic HuR in familial adenomatous polyposis Lodewijk A.A. Brosens, Josbert J. Keller, Leena Pohjola, Caj Haglund,…”
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Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways by Padavano, Julianna, Henkhaus, Rebecca S., Chen, Hwudaurw, Skovan, Bethany A., Cui, Haiyan, Ignatenko, Natalia A.

“…Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies, characterized by the local invasion into surrounding tissues and early metastasis…”
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Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI by Sinharay, Sanhita, Randtke, Edward A., Howison, Christine M., Ignatenko, Natalia A., Pagel, Mark D.

“…Purpose The detection of enzyme activities and evaluation of enzyme inhibitors have been challenging with magnetic resonance imaging (MRI). To address this…”
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Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein by Chen, Hwudaurw, Sells, Earlphia, Pandey, Ritu, Abril, Edward R, Hsu, Chiu-Hsieh, Krouse, Robert S, Nagle, Raymond B, Pampalakis, Georgios, Sotiropoulou, Georgia, Ignatenko, Natalia A

“…Kallikrein-related peptidase 6 (KLK6) overexpression is commonly observed in primary tumors of colorectal cancer (CRC) patients and has been associated with…”
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Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer by Pandey, Ritu, Zhou, Muhan, Chen, Yuliang, Darmoul, Dalila, Kisiel, Conner C., Nfonsam, Valentine N., Ignatenko, Natalia A.

“…Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. The high mortality of CRC is related to its ability to metastasize…”
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Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6 by De Vita, Elena, Smits, Niels, Hurk, Helma, Beck, Elizabeth M., Hewitt, Joanne, Baillie, Gemma, Russell, Emily, Pannifer, Andrew, Hamon, Véronique, Morrison, Angus, McElroy, Stuart P., Jones, Philip, Ignatenko, Natalia A., Gunkel, Nikolas, Miller, Aubry K.

“…Kallikrein‐related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins. Aberrant expression of KLK6 has been…”
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Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography by LeGendre-McGhee, Susan, Rice, Photini S., Wall, R. Andrew, Sprute, Kyle J., Bommireddy, Ramireddy, Luttman, Amber M., Nagle, Raymond B., Abril, Edward R., Farrell, Katrina, Hsu, Chiu-Hsieh, Roe, Denise J., Gerner, Eugene W., Ignatenko, Natalia A., Barton, Jennifer K.

“…Optical coherence tomography (OCT) is a high-resolution, nondestructive imaging modality that enables time-serial assessment of adenoma development in the…”
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A Comprehensive Strategy to Combat Colon Cancer Targeting the Adenomatous Polyposis Coli Tumor Suppressor Gene by GERNER, EUGENE W., IGNATENKO, NATALIA A., LANCE, PETER, HURLEY, LAURENCE H.

“…: Somatic cells in the majority of colorectal polyps and cancers contain mutations/deletions in the adenomatous polyposis coli (APC) tumor suppressor gene. APC…”
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Gene Expression Analysis of HCT116 Colon Tumor-derived Cells Treated with the Polyamine Analog PG-11047 by Ignatenko, Natalia A, Yerushalmi, Hagit F, Pandey, Ritu, Kachel, Karen L, Stringer, David E, Marton, Laurence J, Gerner, Eugene W

“…Background: The conformationally restricted polyamine analog PG-11047 has significant growth inhibitory activity against prostate and lung cancer cell lines…”
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Influence of K-ras Activation on the Survival Responses of Caco-2 Cells to the Chemopreventive Agents Sulindac and Difluoromethylornithine by LAWSON, Kathryn R, IGNATENKO, Natalia A, PIAZZA, Gary A, CUI, Hiayan, GERNER, Eugene W

“…The nonsteroidal anti-inflammatory drug sulindac and the ornithine decarboxylase inhibitor difluoromethylornithine (DFMO) are both potent inhibitors of colon…”
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Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells by Henkhaus, Rebecca S, Gerner, Eugene W, Ignatenko, Natalia A

“…Kallikrein 6 (KLK6) is a trypsin-like serine peptidase whose relevance in various types of cancers is currently being explored. Previous studies have shown…”
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Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention? by Rice, Photini F S, Ehrichs, Kevin G, Jones, Mykella S, Chen, Hwudarw, Hsu, Chiu-Hsieh, Abril, Edward R, Nagle, Raymond B, Besselsen, David G, Barton, Jennifer K, Ignatenko, Natalia A

“…The NSAID sulindac has been successfully used alone or in combination with other agents to suppress colon tumorigenesis in patients with genetic predisposition…”
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Get the Fat Out by IGNATENKO, Natalia A, GERNER, Eugene W

“…Obesity is associated with increased risk of a number of cancers in humans, but the mechanism(s) responsible for these associations have not been established…”
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