Search Results - "IGNASIAK, D. P"

Effect of adenosine deaminase inhibition with pentostatin on myocardial stunning in dogs by MCCLANAHAN, T. B, IGNASIAK, D. P, MARTIN, B. J, MERTZ, T. E, GALLAGHER, K. P

“…Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional…”
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Heat stress increases cardiac HSP72i but fails to reduce myocardial infarct size in rabbits 24 hours later by Saganek, L J, Ignasiak, D P, Batley, B L, Potoczak, R E, Dodd, G, Gallagher, K P

“…Recent reports suggest that delayed myocardial protection ("second window of preconditioning") occurs 24 hours after brief ischemic or thermal stress. In order…”
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Myocardial infarct size is smaller in dogs with pacing-induced heart failure by Hoskins, Darrell E., Ignasiak, Diane P., Saganek, Lori J., Gallagher, Kim P., Peterson, J.Thomas

“…Objective: Determine if ischemic tolerance is reduced in the setting of experimental heart failure (HF). Methods: Dogs were paced for 3 weeks at 240 BPM to…”
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Effects of Endothelin-Receptor Antagonism with PD156707 on Myocardial Stunning in Swine by McClanahan, Thomas B, Mertz, Thomas E, Ignasiak, Diane P, Juneau, Paul L, Gallagher, Kim P

“…SUMMARYEndothelin (ET) has been proposed to play a role in the pathogenesis of myocardial ischemia/reperfusion injury. The potential role of ET in myocardial…”
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Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors by Dudley, Danette A, Bunker, Amy M, Chi, Liguo, Cody, Wayne L, Holland, Debra R, Ignasiak, Diane P, Janiczek-Dolphin, Nancy, McClanahan, Thomas B, Mertz, Thomas E, Narasimhan, Lakshmi S, Rapundalo, Stephen T, Trautschold, Julia A, Van Huis, Chad A, Edmunds, Jeremy J

“…Inappropriate thrombus formation within blood vessels is the leading cause of mortality in the industrialized world. Factor Xa (FXa) is a trypsin-like serine…”
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Effects of endothelin ETA receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits by IGNASIAK, D. P, MCCLANAHAN, T. B, SAGANEK, L. J, POTOCZAK, R. E, HALLAK, H, GALLAGHER, K. P

“…The objective of this study was to determine the in vivo effectiveness of the selective endothelin ETA receptor antagonist PD 156707 (sodium…”
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The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis by MCCLANAHAN, Thomas B, HICKS, Gary W, IGNASIAK, Diane P, BOUSLEY, Richard, MERTZ, Thomas E, JUNEAU, Paul, JANICZEK-DOLPHIN, Nancy, KIM, In-Chull, GALLAGHER, Kim P

“…Direct thrombin inhibitors represent a new class of drug that may offer a therapeutic alternative for the treatment and prevention of thrombembolic conditions,…”
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Antithrombotic effects of BCH 2763, a new direct thrombin inhibitor, in a canine model of venous thrombosis by McClanahan, T B, Ignasiak, D P, Juneau, P, Finkle, C, Winocour, P D, Gallagher, K P

“…Deep venous thrombosis (DVT) is a common cardiovascular disease, resulting in significant mortality each year in the United States. Direct thrombin inhibitors…”
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Does adenosine deaminase inhibition protect ischemic myocardium? by Gallagher, K P, McClanahan, T B, Martin, B J, Saganek, L J, Ignasiak, D P, Mertz, T E, Van Wylen, D G, Vinten-Johansen, J

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Heat stress increases cardiac HSP72i but fails to reduce myocardial infarct size in rabbits 24 hours later by Sagenek, L. J., Ignasiak, D. P., Batley, B. L., Potoczak, R. E., Dodd, G., Gallagher, K. P.

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Effects of endothelin ET A receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits by Ignasiak, Diane P, McClanahan, Thomas B, Saganek, Lori J, Potoczak, Ronald E, Hallak, Hussein, Gallagher, Kim P

“…The objective of this study was to determine the in vivo effectiveness of the selective endothelin ET A receptor antagonist PD 156707 {sodium…”
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Effects of Intravenous Enoxaparin and Intravenous Inogatran in an Electrolytic Injury Model of Venous Thrombosis in the Dog by Ignasiak, DP, McClanahan, TB, Bousley, RE, Juneau, PL, Gallagher, KP

“…The objective of this study was to compare the effectiveness of the low molecular weight heparin, enoxaparin (Lovenox((R))), and inogatran (a direct thrombin…”
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