Search Results - "ICHIDA, KIMIYOSHI"

ABCG2 as a therapeutic target candidate for gout by Fujita, Kyoko, Ichida, Kimiyoshi

“…Hyperuricemia (chronically elevated serum uric acid) is the main pathology underlying the development of gout, the most common inflammatory arthropathy…”
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Electrochemical analysis of uric acid excretion to the intestinal lumen: Effect of serum uric acid-lowering drugs and 5/6 nephrectomy on intestinal uric acid levels by Fujita, Kyoko, Yamada, Hiroki, Iijima, Masahiro, Ichida, Kimiyoshi

“…Recently, extensive efforts have been made to understand the importance of the extra-renal uric acid (UA) excretion pathways and their contribution to…”
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A letter of reply to the commentary by Dr. Stamp et al by Ichida, Kimiyoshi

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Genetic Basis of the Epidemiological Features and Clinical Significance of Renal Hypouricemia by Hakoda, Masayuki, Ichida, Kimiyoshi

“…A genetic defect in urate transporter 1 (URAT1) is the major cause of renal hypouricemia (RHUC). Although RHUC is detected using a serum uric acid (UA)…”
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Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans by Ichida, Kimiyoshi, Amaya, Yoshihiro, Okamoto, Ken, Nishino, Takeshi

“…Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid with concomitant reduction of either NAD+ or O(2)…”
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Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations by Miyata, Hiroshi, Takada, Tappei, Toyoda, Yu, Matsuo, Hirotaka, Ichida, Kimiyoshi, Suzuki, Hiroshi

“…ATP-binding cassette transporter G2 (ABCG2) is a plasma membrane protein that regulates the pharmacokinetics of a variety of drugs and serum uric acid (SUA)…”
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Pharmacokinetics and toxicokinetics of d-serine in rats by Hasegawa, Hiroshi, Masuda, Nami, Natori, Hiromi, Shinohara, Yoshihiko, Ichida, Kimiyoshi

“…•We investigated the relationship of d-serine kinetics with nephrotoxicity in rats.•Following iv/po/ip d-serine, we measured plasma d-/l-serine with…”
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Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia by Sugihara, Shinobu, Hisatome, Ichiro, Kuwabara, Masanari, Niwa, Koichiro, Maharani, Nani, Kato, Masahiko, Ogino, Kazuhide, Hamada, Toshihiro, Ninomiya, Haruaki, Higashi, Yukihito, Ichida, Kimiyoshi, Yamamoto, Kazuhiro

“…Background:Uric acid (UA) serves as an antioxidant in vascular endothelial cells. UA transporter 1 (URAT1) encoded by SLC22A12 is expressed in the kidney and…”
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What lies behind serum urate concentration? Insights from genetic and genomic studies by Ichida, Kimiyoshi

“…Many factors, including genetic components and acquired factors such as obesity and alcohol consumption, influence serum uric acid (urate) concentrations…”
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Decreased extra-renal urate excretion is a common cause of hyperuricemia by Ichida, Kimiyoshi, Matsuo, Hirotaka, Takada, Tappei, Nakayama, Akiyoshi, Murakami, Keizo, Shimizu, Toru, Yamanashi, Yoshihide, Kasuga, Hiroshi, Nakashima, Hiroshi, Nakamura, Takahiro, Takada, Yuzo, Kawamura, Yusuke, Inoue, Hiroki, Okada, Chisa, Utsumi, Yoshitaka, Ikebuchi, Yuki, Ito, Kousei, Nakamura, Makiko, Shinohara, Yoshihiko, Hosoyamada, Makoto, Sakurai, Yutaka, Shinomiya, Nariyoshi, Hosoya, Tatsuo, Suzuki, Hiroshi

“…ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been…”
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Urate Transporter ABCG2 Function and Asymptomatic Hyperuricemia: A Retrospective Cohort Study of CKD Progression by Ohashi, Yuki, Kuriyama, Satoru, Nakano, Tomoko, Sekine, Mai, Toyoda, Yu, Nakayama, Akiyoshi, Takada, Tappei, Kawamura, Yusuke, Nakamura, Takahiro, Matsuo, Hirotaka, Yokoo, Takashi, Ichida, Kimiyoshi

“…Treatment of asymptomatic hyperuricemia is not commonly implemented. However, it is unclear whether urate deposition that begins during asymptomatic…”
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A Novel PRPS1 Mutation in a Japanese Patient with CMTX5 by Shirakawa, Shunichi, Murakami, Tatsufumi, Hashiguchi, Akihiro, Takashima, Hiroshi, Hasegawa, Hiroshi, Ichida, Kimiyoshi, Sunada, Yoshihide

“…The PRPS1 gene encodes phosphoribosyl pyrophosphate synthetase 1 (PRS-1). The phenotypes associated with PRPS1 mutations include DFN2 (mild PRS-1 deficiency),…”
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Urate Transport via Paracellular Route across Epithelial Cells by Kimura, Toru, Tsukada, Ai, Fukutomi, Toshiyuki, Ichida, Kimiyoshi, Ohtsuki, Sumio, Sakurai, Hiroyuki

“…Urate is the final oxidation product of purine metabolism in humans. We have recently reported that the paracellular route is the major urate transport pathway…”
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Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans by Anzai, Naohiko, Ichida, Kimiyoshi, Jutabha, Promsuk, Kimura, Toru, Babu, Ellappan, Jin, Chun Ji, Srivastava, Sunena, Kitamura, Kenichiro, Hisatome, Ichiro, Endou, Hitoshi, Sakurai, Hiroyuki

“…Hyperuricemia is a significant factor in a variety of diseases, including gout and cardiovascular diseases. Although renal excretion largely determines plasma…”
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SNP-based heritability estimates of gout and its subtypes determined by genome-wide association studies of clinically defined gout by Toyoda, Yu, Nakatochi, Masahiro, Nakayama, Akiyoshi, Kawamura, Yusuke, Nakaoka, Hirofumi, Wakai, Kenji, Matsuo, Keitaro, Matsuo, Hirotaka

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Evaluation of ABCG2-mediated extra-renal urate excretion in hemodialysis patients by Ohashi, Yuki, Toyoda, Masao, Saito, Nobumichi, Koizumi, Masahiro, Kanai, Genta, Komaba, Hirotaka, Kimura, Moritsugu, Wada, Takehiko, Takahashi, Hiroo, Takahashi, Yuichiro, Ishida, Naoto, Kakuta, Takatoshi, Fukagawa, Masafumi, Ichida, Kimiyoshi

“…Two-thirds of urate is excreted via the renal pathway and the remaining one-third via the extra-renal pathway, the latter mainly via the intestine in healthy…”
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Characterization of Urate Metabolism and Complications of Patients with Renal Hypouricemia by Miyazaki, Satoshi, Hamada, Toshihiro, Isoyama, Tadahiro, Okada, Shinichi, Tomita, Katsuyuki, Endo, Yusuke, Kuwabara, Masanari, Sugihara, Shinobu, Ogino, Kazuhide, Ninomiya, Haruaki, Ichida, Kimiyoshi, Yamamoto, Kazuhiro, Takenaka, Atsushi, Hisatome, Ichiro

“…Objective Both renal hypouricemia (RHU) and gout are associated with renal dysfunction and urolithiasis. The difference in renal complications associated with…”
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Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase by Sekine, Mai, Okamoto, Ken, Ichida, Kimiyoshi

“…Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from hypoxanthine to xanthine and from xanthine to uric acid in purine…”
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Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels by Higashino, Toshihide, Morimoto, Keito, Nakaoka, Hirofumi, Toyoda, Yu, Kawamura, Yusuke, Shimizu, Seiko, Nakamura, Takahiro, Hosomichi, Kazuyoshi, Nakayama, Akiyoshi, Ooyama, Keiko, Ooyama, Hiroshi, Shimizu, Toru, Ueno, Miki, Ito, Toshimitsu, Tamura, Takashi, Naito, Mariko, Nakashima, Hiroshi, Kawaguchi, Makoto, Takao, Mikiya, Kawai, Yosuke, Osada, Naoki, Ichida, Kimiyoshi, Yamamoto, Ken, Suzuki, Hiroshi, Shinomiya, Nariyoshi, Inoue, Ituro, Takada, Tappei, Matsuo, Hirotaka

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Genetic epidemiological analysis of hypouricaemia from 4993 Japanese on non-functional variants of URAT1/SLC22A12 gene by Nakayama, Akiyoshi, Kawamura, Yusuke, Toyoda, Yu, Shimizu, Seiko, Kawaguchi, Makoto, Aoki, Yuka, Takeuchi, Kenji, Okada, Rieko, Kubo, Yoko, Imakiire, Toshihiko, Iwasawa, Satoko, Nakashima, Hiroshi, Tsunoda, Masashi, Ito, Keiichi, Kumagai, Hiroo, Takada, Tappei, Ichida, Kimiyoshi, Shinomiya, Nariyoshi, Matsuo, Hirotaka

“…Abstract Objectives Up to 0.3% of Japanese have hypouricaemia. Most cases appear to result from a hereditary disease, renal hypouricaemia (RHUC), which causes…”
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