Search Results - "IBA, Michael M"

Cytochromes P4501 (CYP1): Catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo by Iba, Michael M, Shin, Maria, Caccavale, Robert J

“…Abstract Catalytic activities of CYP1A1, CYP1A2 and CYP1B1, and inducibility of the activities were studied in intact human lung samples (from 23 human…”
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The Effects of Panax Notoginseng Saponins (PNS) on the Activities of 'Rat' CYP2C9, CYP2D6 and CYP3A4 by Iba, Michael M.

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Genotoxic bioactivation of constituents of a diesel exhaust particle extract by the human lung by Iba, Michael M., Caccavale, Robert J.

“…The ability of the human lung to catalyze genotoxic bioactivation of constituents of diesel exhaust particle (DEP) extract (DEPE) and the identity of the lung…”
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Simultaneous and Sensitive Measurement of Anabasine, Nicotine, and Nicotine Metabolites in Human Urine by Liquid Chromatography-Tandem Mass Spectrometry by Xu, Xu, Iba, Michael M, Weisel, Clifford P

“…Determination of nicotine metabolism/pharmacokinetics provides a useful tool for estimating uptake of nicotine and tobacco-related toxicants, for understanding…”
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Effect of n-hexane on the disposition and toxicity of the 1,3-butadiene metabolite 3-butene-1,2-diol by Iba, Michael M., Bird, Michael G.

“…3-Butene-1,2-diol (butenediol), a major metabolite of 1,3-butadiene (butadiene), can undergo either detoxification or biotransformation to potentially toxic…”
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Induction of CYP1A1 and CYP1A2 expressions by prototypic and atypical inducers in the human lung by Wei, Cindy, Caccavale, Robert J, Weyand, Eric H, Chen, Suzie, Iba, Michael M

“…The inducibility of cytochrome P4501A1 gene ( CYP1A1) expression was examined in human lung samples from 27 subjects, using an explant culture system and…”
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Influence of oxygenated fuel additives and their metabolites on γ-aminobutyric acidA (GABAA) receptor function in rat brain synaptoneurosomes by MARTIN, Joseph V, IYER, Sonal V, MCILROY, Patrick J, IBA, M. Michael

“…Experimental and occupational inhalational exposure to oxygenate fuel additives in reformulated gasoline has been reported to induce neurological symptoms…”
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Differential inducibility of rat pulmonary CYP1A1 by cigarette smoke and wood smoke by Iba, Michael M., Fung, Jacqueline, Chung, Le, Zhao, Jason, Winnik, Bozena, Buckley, Brian T., Chen, Lung Chi, Zelikoff, Judith T., Kou, Yu Ru

“…Mainstream cigarette smoke (CS) and wood smoke (WS) were compared in terms of their pulmonary CYP1A1 inducibility. The inducibility was assessed in pulmonary…”
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Constitutive and inducible levels of CYP1A1 and CYP1A2 in rat cerebral cortex and cerebellum by IBA, Michael M, STORCH, Amijoy, GHOSAL, Anima, BENNETT, Susan, REUHL, Kenneth R, LOWNDES, Herbert E

“…We examined the constitutive and inducible levels of microsomal cytochromes P450 1A1 and 1A2 (CYP1A) in rat cerebral cortex and cerebellum at the level of…”
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Pulmonary CYP1A1 and CYP1A2 levels and activities in adult male and female offspring of rats exposed during gestation and lactation to 2,3,7,8-tetrachlorodibenzo- p-dioxin by Iba, Michael M., Fung, Jacqueline

“…The levels and activities of pulmonary microsomal CYP1A1 and CYP1A2 in 40-day-old male and female, and 120-day-old male offspring of pregnant rats treated with…”
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Dose-Dependent Up-Regulation of Rat Pulmonary, Renal, and Hepatic Cytochrome P-450 (CYP) 1A Expression by Nicotine Feeding by Iba, M M, Fung, J, Pak, Y W, Thomas, P E, Fisher, H, Sekowski, A, Halladay, A K, Wagner, G C

“…In a previous study in which a single 2.5 mg/kg (15.4 μmol/kg) s.c. dose of nicotine effected a transient, lung-specific induction of cytochrome P-450 (CYP)…”
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Induction of pulmonary cytochrome P4501A1: interactive effects of nicotine and mecamylamine by Iba, Michael M, Fung, Jacqueline

“…The effect of the nicotinic receptor antagonist mecamylamine on nicotine-mediated convulsions and induction of pulmonary cytochrome P4501A1 (CYP1A1) was…”
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CYP1A2 is expressed along with CYP1A1 in the human lung by Wei, Cindy, Cacavale, Robert J., Kehoe, John J., Thomas, Paul E., Iba, Michael M.

“…The expression and activity of CYP1A1 were examined in fresh, small-sized lung biopsy specimens from nine human subjects. CYP1A1 transcripts were detected by…”
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Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of δ-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats by Iba, Michael M, Alam, Jawed, Touchard, Cheri, Thomas, Paul E, Ghosal, Anima, Fung, Jacqueline

“…To determine the changes in heme metabolism associated with induction of cytochrome P450 expression by pyridine, we compared the time course of CYP1A…”
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Comparative metabolism of [14C]benzene to excretable products and bioactivation to DNA-binding derivatives in maternal and neonatal mice by IBA, Michael M, GHOSAL, Anima, SNYDER, Robert

“…Lactating adult female mice treated with a single dose of 880 mg/kg i.p. [14C]benzene, and their 2-day-old sucklings similarly treated or nursed by their…”
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Cytochrome P450 1A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[ a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro by Fung, Jacqueline, Thomas, Paul E., Iba, Michael M.

“…The presence and inducibility of CYP1A1 in freshly isolated peripheral blood lymphocytes was examined in untreated rats and in rats pretreated with agents…”
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Effect of gestational and lactational 2,3,7,8-tetrachlorodibenzo- p-dioxin exposure on the level and catalytic activities of hepatic microsomal CYP1A in prepubertal and adult rats by Iba, Michael M, Fung, Jacqueline, Cooper, Keith R, Thomas, Paul E, Wagner, George C, Park, Yangwon

“…We determined the inducibility, as well as the persistence of the induction, of hepatic microsomal CYP1A1 and CYP1A2 (by western blot analysis), and their…”
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Pulmonary CYP1A1 and CYP1A2 levels and activities in adult male and female offspring of rats exposed during gestation and lactation to 2,3,7,8-tetrachlorodibenzo-p-dioxin11Abbreviations: AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; AUC, area under the curve; B[a]P, benzo[a]pyrene; CYP1A, used to include CYP1A1 and CYP1A2; EROD, ethoxyresorufin O-deethylase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; MeIQ, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline; PCR, polymerase chain by Iba, Michael M., Fung, Jacqueline

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CYP1A2 is expressed along with CYP1A1 in the human lung by Wei, Cindy, Caccavale, Robert J., Kehoe, John J., Thomas, Paul E., Iba, Michael M.

“…The expression and activity of CYP1A1 were examined in fresh, small-sized lung biopsy specimens from nine human subjects. CYP1A1 transcripts were detected by…”
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Influence of oxygenated fuel additives and their metabolites on γ-aminobutyric acid A (GABA A) receptor function in rat brain synaptoneurosomes by Martin, Joseph V, Iyer, Sonal V, McIlroy, Patrick J, Michael Iba, M

“…Experimental and occupational inhalational exposure to oxygenate fuel additives in reformulated gasoline has been reported to induce neurological symptoms…”
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