Search Results - "IANZANO, L"

Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations by Nanni, Patrizia, Landuzzi, Lorena, Manara, Maria Cristina, Righi, Alberto, Nicoletti, Giordano, Cristalli, Camilla, Pasello, Michela, Parra, Alessandro, Carrabotta, Marianna, Ferracin, Manuela, Palladini, Arianna, Ianzano, Marianna L., Giusti, Veronica, Ruzzi, Francesca, Magnani, Mauro, Donati, Davide Maria, Picci, Piero, Lollini, Pier-Luigi, Scotlandi, Katia

“…Standard therapy of osteosarcoma (OS) and Ewing sarcoma (EW) rests on cytotoxic regimes, which are largely unsuccessful in advanced patients. Preclinical…”
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A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation by Grassilli, E, Pisano, F, Cialdella, A, Bonomo, S, Missaglia, C, Cerrito, M G, Masiero, L, Ianzano, L, Giordano, F, Cicirelli, V, Narloch, R, D’Amato, F, Noli, B, Ferri, G L, Leone, B E, Stanta, G, Bonin, S, Helin, K, Giovannoni, R, Lavitrano, M

“…Bruton’s tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited…”
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Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation by Grassilli, E., Pisano, F., Cialdella, A., Bonomo, S., Missaglia, C., Cerrito, M. G., Masiero, L., Ianzano, L., Giordano, F., Cicirelli, V., Narloch, R., D’Amato, F., Noli, B., Ferri, G. L., Leone, B. E., Stanta, G., Bonin, S., Helin, K., Giovannoni, R., Lavitrano, M.

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Virus-like particle display of HER2 induces potent anti-cancer responses by Palladini, Arianna, Thrane, Susan, Janitzek, Christoph M., Pihl, Jessica, Clemmensen, Stine B., de Jongh, Willem Adriaan, Clausen, Thomas M., Nicoletti, Giordano, Landuzzi, Lorena, Penichet, Manuel L., Balboni, Tania, Ianzano, Marianna L., Giusti, Veronica, Theander, Thor G., Nielsen, Morten A., Salanti, Ali, Lollini, Pier-Luigi, Nanni, Patrizia, Sander, Adam F.

“…Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20-30% of invasive breast cancers. Monoclonal antibody therapy is effective in…”
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Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor by Nanni, Patrizia, Nicoletti, Giordano, Palladini, Arianna, Croci, Stefania, Murgo, Annalisa, Ianzano, Marianna L, Grosso, Valentina, Stivani, Valeria, Antognoli, Agnese, Lamolinara, Alessia, Landuzzi, Lorena, di Tomaso, Emmanuelle, Iezzi, Manuela, De Giovanni, Carla, Lollini, Pier-Luigi

“…In vivo studies of the metastatic process are severely hampered by the fact that most human tumor cell lines derived from highly metastatic tumors fail to…”
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Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis by De Giovanni, Carla, Nanni, Patrizia, Landuzzi, Lorena, Ianzano, Marianna L, Nicoletti, Giordano, Croci, Stefania, Palladini, Arianna, Lollini, Pier-Luigi

“…Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several…”
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Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression by Giusti, Veronica, Ruzzi, Francesca, Landuzzi, Lorena, Ianzano, Marianna L., Laranga, Roberta, Nironi, Elena, Scalambra, Laura, Nicoletti, Giordano, De Giovanni, Carla, Olivero, Martina, Arigoni, Maddalena, Calogero, Raffaele, Nanni, Patrizia, Palladini, Arianna, Lollini, Pier-Luigi

“…HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In this work, we studied cell lines derived from two transgenic mammary…”
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p65BTK targeting restores the apoptotic response to chemotherapy of p53-null drug-resistant colon cancer cells by Ianzano, L, Bonomo, S, Cialdella, A, Pisano, F, Cerrito, M.G, Carola, M, McLean, C, Romano, G, Giovannoni, R, Agostini, M, Nitti, D, Voest, E, Helin, K, Lavitrano, M, Grassilli, E

“…We recently identified p65BTK, a novel oncogenic isoform of Bruton tyrosine kinase abundantly expressed in colon cancer cell lines and tissues (Grassilli et…”
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Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomas by Landuzzi, Lorena, Ianzano, Marianna L, Nicoletti, Giordano, Palladini, Arianna, Grosso, Valentina, Ranieri, Dario, Dall'Ora, Massimiliano, Raschi, Elena, Laranga, Roberta, Gambarotti, Marco, Picci, Piero, De Giovanni, Carla, Nanni, Patrizia, Lollini, Pier-Luigi

“…Homozygous knockout of p53 in mice leads to early mortality from lymphoma, with almost complete penetrance, thus hampering studies of other tumor histotypes…”
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Early stability and late random tumor progression of a HER2-positive primary breast cancer patient-derived xenograft by Landuzzi, Lorena, Palladini, Arianna, Ceccarelli, Claudio, Asioli, Sofia, Nicoletti, Giordano, Giusti, Veronica, Ruzzi, Francesca, Ianzano, Marianna L., Scalambra, Laura, Laranga, Roberta, Balboni, Tania, Arigoni, Maddalena, Olivero, Martina, Calogero, Raffaele A., De Giovanni, Carla, Dall’Ora, Massimiliano, Di Oto, Enrico, Santini, Donatella, Foschini, Maria Pia, Cucchi, Maria Cristina, Zanotti, Simone, Taffurelli, Mario, Nanni, Patrizia, Lollini, Pier-Luigi

“…We established patient-derived xenografts (PDX) from human primary breast cancers and studied whether stability or progressive events occurred during long-term…”
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Human responses against HER-2-positive cancer cells in human immune system-engrafted mice by De Giovanni, C, Nicoletti, G, Landuzzi, L, Romani, F, Croci, S, Palladini, A, Murgo, A, Antognoli, A, Ianzano, M L, Stivani, V, Grosso, V, Iezzi, M, Stramucci, L, Barbieri, E, Lemoli, R M, Nanni, P, Lollini, P-L

“…Background: Human immune system (HIS)-engrafted mice are new tools to investigate human immune responses. Here, we used HIS mice to study human immune…”
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Genetic diagnosis in Lafora disease : Genotype-phenotype correlations and diagnostic pitfalls by LOHI, H, TURNBULL, J, ZHAO, X. C, PULLENAYEGUM, S, IANZANO, L, YAHYAOUI, M, MIKATI, M. A, FRANCESCHETTI, S, ZARA, F, MINASSIAN, B. A

“…Lafora disease (LD) can be diagnosed by skin biopsy, but this approach has both false negatives and false positives. Biopsies of other organs can also be…”
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Mutation spectrum and predicted function of laforin in Lafora's progressive myoclonus epilepsy by MINASSIAN, B. A, IANZANO, L, MELOCHE, M, ANDERMANN, E, ROULEAU, G. A, DELGADO-ESCUETA, A. V, SCHERER, S. W

“…Lafora's disease is a progressive myoclonus epilepsy with pathognomonic inclusions (polyglucosan bodies) caused by mutations in the EPM2A gene. EPM2A codes for…”
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In silico Modeling and In vivo Efficacy of Cancer-Preventive Vaccinations by PALLADINI, Arianna, NICOLETTI, Giordano, DE GIOVANNI, Carla, NANNI, Patrizia, MOTTA, Santo, LOLLINI, Pier-Luigi, PAPPALARDO, Francesco, MURGO, Annalisa, GROSSO, Valentina, STIVANI, Valeria, LANZANO, Marianna L, ANTOGNOLI, Agnese, CROCI, Stefania, LANDUZZI, Lorena

“…Cancer vaccine feasibility would benefit from reducing the number and duration of vaccinations without diminishing efficacy. However, the duration of in vivo…”
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HER2 isoforms co-expression differently tunes mammary tumor phenotypes affecting onset, vasculature and therapeutic response by Palladini, Arianna, Nicoletti, Giordano, Lamolinara, Alessia, Dall'Ora, Massimiliano, Balboni, Tania, Ianzano, Marianna L, Laranga, Roberta, Landuzzi, Lorena, Giusti, Veronica, Ceccarelli, Claudio, Santini, Donatella, Taffurelli, Mario, Di Oto, Enrico, Asioli, Sofia, Amici, Augusto, Pupa, Serenella M, De Giovanni, Carla, Tagliabue, Elda, Iezzi, Manuela, Nanni, Patrizia, Lollini, Pier-Luigi

“…Full-length HER2 oncoprotein and splice variant Delta16 are co-expressed in human breast cancer. We studied their interaction in hybrid transgenic mice bearing…”
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Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice by Ianzano, Marianna L, Croci, Stefania, Nicoletti, Giordano, Palladini, Arianna, Landuzzi, Lorena, Grosso, Valentina, Ranieri, Dario, Dall'Ora, Massimiliano, Santeramo, Ilaria, Urbini, Milena, De Giovanni, Carla, Lollini, Pier-Luigi, Nanni, Patrizia

“…Human sarcomas arise suddenly, thus preempting the study of preneoplastic and early neoplastic lesions. To explore the natural history of these tumors we…”
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High metastatic efficiency of human sarcoma cells in Rag2/γc double knockout mice provides a powerful test system for antimetastatic targeted therapy by Nanni, Patrizia, Nicoletti, Giordano, Landuzzi, Lorena, Croci, Stefania, Murgo, Annalisa, Palladini, Arianna, Antognoli, Agnese, Ianzano, Marianna L, Stivani, Valeria, Grosso, Valentina, Maira, Sauveur-Michel, García-Echeverría, Carlos, Scotlandi, Katia, De Giovanni, Carla, Lollini, Pier-Luigi

“…Abstract Immunodeficient animal models are invaluable tools to investigate the metastatic propensity of human tumours. However residual immune responses, in…”
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Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis by Croci, Stefania, Nanni, Patrizia, Palladini, Arianna, Nicoletti, Giordano, Grosso, Valentina, Benegiamo, Giorgia, Landuzzi, Lorena, Lamolinara, Alessia, Ianzano, Marianna L, Ranieri, Dario, Dall'Ora, Massimiliano, Iezzi, Manuela, De Giovanni, Carla, Lollini, Pier-Luigi

“…We previously demonstrated that HER2/neu-driven mammary carcinogenesis can be prevented by an interleukin-12 (IL-12)-adjuvanted allogeneic HER2/neu-expressing…”
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The Genomic Organization of the Fanconi Anemia Group A (FAA) Gene by Ianzano, Leonarda, d'Apolito, Maria, Centra, Marta, Savino, Maria, Levran, Orna, Auerbach, Arleen D., Cleton-Jansen, Anne-Marie, Doggett, Norman A., Pronk, Jan C., Tipping, Alex J., Gibson, Rachel A., Mathew, Christopher G., Whitmore, Scott A., Apostolou, Sinoula, Callen, David F., Zelante, Leopoldo, Savoia, Anna

“…Fanconi anemia (FA) is a genetically heterogenous disease involving at least five genes on the basis of complementation analysis (FAAtoFAE). TheFAAgene has…”
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428 - p65BTK targeting restores the apoptotic response to chemotherapy of p53-null drug-resistant colon cancer cells by Ianzano, L., Bonomo, S., Cialdella, A., Pisano, F., Cerrito, M.G., Carola, M., McLean, C., Romano, G., Giovannoni, R., Agostini, M., Nitti, D., Voest, E., Helin, K., Lavitrano, M., Grassilli, E.

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